| Weber's syndrome | |
|---|---|
| Classification and external resources | |
 Midbrain cross section showing lesion |
|
| ICD-10 | G46.3 |
| ICD-9 | 344.89 |
| DiseasesDB | 31247 |
| MeSH | D020526 |
Weber's syndrome (superior alternating hemiplegia) is a form of stroke characterized by the presence of an oculomotor nerve palsy and contralateral hemiparesis or hemiplegia.
Contents |
Cause and presentation [edit]
This lesion is usually unilateral and affects several structures in the midbrain including:
| Structure damaged | Effect |
|---|---|
| substantia nigra | contralateral parkinsonism because its dopaminergic projections to the basal ganglia innervate the ipsilateral hemisphere motor field, leading to a movement disorder of the contralateral body. |
| corticospinal fibers | contralateral hemiparesis and typical upper motor neuron findings. It is contralateral because it occurs before the decussation in the medulla. |
| corticobulbar tract | difficulty with contralateral lower facial muscles and hypoglossal nerve functions |
| oculomotor nerve fibers | ipsilateral oculomotor nerve palsy with a drooping eyelid and fixed wide pupil pointed down and out. This leads to diplopia |
It is caused by midbrain infarction as a result of occlusion of the paramedian branches of the posterior cerebral artery or of basilar bifurcation perforating arteries.[1]
History [edit]
It carries the name of Sir Hermann David Weber, a German-born physician working in London, who described the condition in 1863.[2][3] It is unrelated to Sturge-Weber syndrome, Klippel-Trenaunay-Weber syndrome or Osler-Weber-Rendu syndrome.
References [edit]
- ^ Weber's syndrome at GPnotebook
- ^ Weber HD (1863). "A contribution to the pathology of the crura cerebri". Medico-Chirurgical Transactions 46: 121–139.
- ^ Weber's syndrome at Who Named It?
External links [edit]
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