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U.S. Route 221 marker

U.S. Route 221
Route information
Maintained by SCDOT
Length: 126 mi[1] (203 km)
Existed: 1932 – present
Major junctions
South end: US 221 / SR 150 at the GA line near Pollards Corner, GA
  I-385 near Watts Mills
I-26 near Moore
I-585 / US 176 / SC 9 in Spartanburg
I-85 near Spartanburg
North end: US 221 at the SC line near Chesnee
Counties: McCormick, Greenwood, Laurens, Spartanburg, Cherokee
Highway system
SC 219 SC 223

U.S. Route 221 (US 221) is a part of the United States Numbered Highway System that runs from Perry in northern Florida to Lynchburg in central Virginia. In South Carolina, the highway runs north to south from the Georgia state line near Clarks Hill to the North Carolina state line near Chesnee. While in the state, the highway passes through Greenwood, Laurens, Woodruff, and Spartanburg. The highway mostly travels through rural parts of the Piedmont region of the state.[1]

Route description[edit]


Established in 1932, US 221 was connected from North Carolina, from north of Cowpens National Battlefield to Greenwood, connecting the cities of Spartanburg, Woodruff, Laurens, and Waterloo. In 1941, US 221 replaced South Carolina Highway 110 (SC 110), going due north from Chesnee to the North Carolina state line; its former route became US 221 Alternate. In 1954, US 221 was extended south to Bradley and McCormick, then south over the Clarks Hill Dam into Georgia; this replaced part of SC 10 and part of SC 670.

Between 1962 and 1964, US 221 bypassed Roebuck. Between 1968 and 1970, US 221 was rerouted onto the Greenwood Bypass and its current routing south of US 25/US 178, replacing the remaining part of SC 670. The old route through Greenwood became SC 72 Business and an extension of SC 10.[2]

Junction list[edit]

County Location Mile Destinations Notes
Lake Strom Thurmond / Savannah River 0.0 Georgia-South Carolina state line
McCormick Clarks Hill 1.8 SC 28 South end of SC 28 concurrency
Modoc 6.2 SC 23 Southern terminus of SC 23
Plum Branch 15.6 SC 283 Northern terminus of SC 283
McCormick 20.4 US 378 (Gold Street) / SC 28 (Mine Street) North end of SC 28 concurrency, south end of US 378 concurrency
21.0 US 378 (Gold Street E) North end of US 378 concurrency
Greenwood Bradley 29.5 SC 10 (McCormick Highway) South end of SC 10 concurrency
31.8 SC 10 (McCormick Highway) North end of SC 10 concurrency
Greenwood 40.2 SC 225
41.1 US 25 / US 178 (Main Street S) South end of US 25 / US 178 concurrency
42.5 SC 34 (Main Street W/Ninety Six Highway)
45.9 US 25 / US 178 / SC 72 (Reynolds Avenue) North end of US 25 / 178 concurrency, south end of SC 72 concurrency
Coronaca 50.8 SC 246
Laurens Waterloo 54.2 SC 72 North end of SC 72 concurrency
Laurens 63.8 SC 39 Northern terminus of SC 39
68.1 SC 127 (Shopping Center 127) Southern terminus of SC 127
70.4 US 76 (Main Street E)
US 76 Byp. (Hillcrest Drive/Fleming Street)
72.4 SC 49 (Yarborough Mill Road) Southern terminus of SC 49
74.6 I-385
Ora 76.8 SC 308 Western terminus of SC 308
Enoree 80.7 SC 92 South end of SC 92 concurrency
Spartanburg 82.2 SC 92 (Parker Road) North end of SC 92 concurrency
Woodruff 89.3 SC 146 (Cross Anchor Road) South end of SC 146 concurrency
89.8 SC 101 (Georgia Street) South end of SC 101 concurrency
90.8 SC 101 / SC 146 North end of SC 146 / SC 101 concurrency
Moore 97.7 SC 290 (Moore Duncan Highway) Eastern terminus of SC 290
Roebuck 98.5 I-26
101.0 SC 215 (Blackstock Road E/Stone Station Road)
103.7 SC 295 (Southport Road)
Spartanburg 106.8 SC 56 (Henry Street) South end of SC 56 concurrency
107.2 US 29 (St John Street)
107.4 SC 296 (Daniel Morgan Avenue E)
108.1 SC 56 (Asheville Highway) North end of SC 56 concurrency
108.9 I-585 / US 176 / SC 9 (Pine Street N)
113.0 I-85
Chesnee 123.0
US 221 Alt. / SC 11 (Cherokee Street/Cherokee Foothills Scenic Highway)
Northern terminus of US 221 Alt
Cherokee 125.9 South Carolina - North Carolina state line

Bannered routes[edit]

There is one alternate route in South Carolina.

See also[edit]


External links[edit]

U.S. Route 221
Previous state:
South Carolina Next state:
North Carolina

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/U.S._Route_221_in_South_Carolina — Please support Wikipedia.
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