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Tick-borne meningoencephalitis virus
Tick-Borne Encephalitis Virus.png
Virus classification
Group: Group IV ((+)ssRNA)
Family: Flaviviridae
Genus: Flavivirus
Species: Tick-borne meningoencephalitis virus

Tick-borne encephalitis virus (TBEV) is the virus associated with tick-borne encephalitis.


TBEV is a member of the genus Flavivirus. Other close relatives include Omsk hemorrhagic fever virus, Kyasanur forest disease virus, Alkhurma virus, Louping ill virus and the Langat virus.


TBEV has three subtypes:

  • Western European subtype (formerly Central European encephalitis virus, CEEV; principal tick vector: Ixodes ricinus);
  • Siberian subtype (formerly West Siberian virus; principal tick vector: Ixodes persulcatus);
  • Far Eastern subtype (formerly Russian Spring Summer encephalitis virus, RSSEV; principal tick vector: Ixodes persulcatus).[1]

The reference strain is the Sofjin strain.[2]


The ancestor of the extant strains appears to have separated into several clades approximately 2750 years ago.[3] The Siberian and Far Eastern subtypes diverged about 2250 years ago.

A second analysis suggests an earlier date of evolution (3300 years ago) with a rapid increase in the number of strains starting ~300 years ago.[4]

This virus has been transmitted at least three times into Japan between 260–430 years ago.[5][6]

The strains circulating in Latvia appear to have originated from both Russia and Western Europe[7] while those in Estonia appear to have originated in Russia.[8] The Lithuanian strains appear to be related to those from Western Europe.[9]


  1. ^ Goodman, Jesse L.; Dennis, David T. & Sonenshine, Daniel E. (2005). "Tick-Borne Encephalitis". Tick-Borne Diseases of Humans. Washington, DC: ASM Press. p. 151. ISBN 1-55581-238-4. 
  2. ^ Kovalev SY, Mukhacheva TA, Kokorev VS, Belyaeva IV (April 2012). "Tick-borne encephalitis virus: reference strain Sofjin and problem of its authenticity". Virus Genes 44 (2): 217–24. doi:10.1007/s11262-011-0690-9. PMID 22095094. 
  3. ^ Subbotina EL, Loktev VB (2012). "Molecular evolution of the tick-borne encephalitis and Powassan viruses". Mol. Biol. 46 (1): 75–84. doi:10.1134/S0026893311060148. PMID 22642104. 
  4. ^ Uzcátegui NY, Sironen T, Golovljova I, et al. (April 2012). "Rate of evolution and molecular epidemiology of tick-borne encephalitis virus in Europe, including two isolations from the same focus 44 years apart". J. Gen. Virol. 93 (Pt 4): 786–96. doi:10.1099/vir.0.035766-0. PMID 22205716. 
  5. ^ Suzuki Y (June 2007). "Multiple transmissions of tick-borne encephalitis virus between Japan and Russia". Genes Genet. Syst. 82 (3): 187–95. doi:10.1266/ggs.82.187. PMID 17660689. 
  6. ^ Takashima I, Hayasaka D, Goto A, Kariwa H, Mizutani T (February 2001). "Epidemiology of tick-borne encephalitis (TBE) and phylogenetic analysis of TBE viruses in Japan and Far Eastern Russia". Jpn. J. Infect. Dis. 54 (1): 1–11. PMID 11326122. 
  7. ^ Lundkvist k, Vene S, Golovljova I; et al. (December 2001). "Characterization of tick-borne encephalitis virus from Latvia: evidence for co-circulation of three distinct subtypes". J. Med. Virol. 65 (4): 730–5. doi:10.1002/jmv.2097. PMID 11745938. 
  8. ^ Golovljova I, Vene S, Sjölander KB, Vasilenko V, Plyusnin A, Lundkvist A (December 2004). "Characterization of tick-borne encephalitis virus from Estonia". J. Med. Virol. 74 (4): 580–8. doi:10.1002/jmv.20224. PMID 15484275. 
  9. ^ Mickiené A, Vene S, Golovljova I, et al. (December 2001). "Tick-borne encephalitis virus in Lithuania". Eur. J. Clin. Microbiol. Infect. Dis. 20 (12): 886–8. doi:10.1007/s10096-001-0637-5. PMID 11837641. 

External links[edit]

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus — Please support Wikipedia.
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30 news items

YLE News

YLE News
Sat, 16 May 2015 09:41:15 -0700

“When the TBE cases came to light, researchers collected tick samples in the archipelago. The viruses they carried were isolated and analysed, and it became clear that it was the Siberian subtype of the tick-borne encephalitis virus that we were ...


Fri, 11 Sep 2015 03:16:08 -0700

Langat virus (LGTV), one of the members of the tick-borne encephalitis virus (TBEV) complex, was firstly isolated from Ixodes granulatus ticks in Malaysia. However, the prevalence of LGTV in ticks in the region remains unknown. Surveillance for LGTV is ...


Mon, 14 Sep 2015 01:48:45 -0700

Vidare har de olika smittsamma sjukdomarna och mikroberna utökats till att förutom Borrelia och tick-borne encephalitis virus (TBEV), också omfatta Anaplasma, Rickettsia, Cand Neoerlichia, Bartonella och Babesia. Parterna representerar breda ...
Duluth News Tribune
Tue, 21 Jul 2015 14:42:23 -0700

"The powassan virus is an emerging tick-borne illness in the United States, but its cousin the tick-borne encephalitis virus, has long been recognized to cause significant illness in Europe." Powassan virus can infect within 15 minutes of the tick bite.

Barfblog (blog)

Barfblog (blog)
Mon, 07 Sep 2015 13:15:00 -0700

In endemic areas, raw milk dairy products may also be contaminated with Brucella spp., Mycobacterium bovis and the tick-borne encephalitis virus (TBEV). Potential risks due to Coxiella burnetii and Mycobacterium avium subsp. paratuberculosis (MAP) are ...

Food Safety News

Food Safety News
Tue, 13 Jan 2015 22:00:00 -0800

... panel stated that there are “clear links” between drinking raw milk and human illnesses associated with Campylobacter, Salmonella, Shiga toxin-producing Escherichia coli (STEC), Brucella melitensis, Mycobacterium bovis and tick-borne encephalitis ...
BMC Blogs Network
Tue, 31 Mar 2015 22:38:54 -0700

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Mon, 15 Mar 2010 00:00:00 -0700

Ticks can transmit a variety of viruses, bacteria or parasites that can cause serious infections or conditions in humans and animals. While tick-borne diseases are becoming an increasing and serious problem in Europe, tick-borne diseases are also ...

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