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Tachykinin receptor 2
Identifiers
Symbols TACR2 ; NK2R; NKNAR; SKR; TAC2R
External IDs OMIM162321 MGI98477 HomoloGene55548 IUPHAR: NK2 ChEMBL: 2327 GeneCards: TACR2 Gene
RNA expression pattern
PBB GE TACR2 214348 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6865 21337
Ensembl ENSG00000075073 ENSMUSG00000020081
UniProt P21452 P30549
RefSeq (mRNA) NM_001057 NM_009314
RefSeq (protein) NP_001048 NP_033340
Location (UCSC) Chr 10:
71.16 – 71.18 Mb
Chr 10:
62.25 – 62.27 Mb
PubMed search [1] [2]

Substance-K receptor is a protein that in humans is encoded by the TACR2 gene.[1]

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.[1]

Selective Ligands[edit]

Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant.

Agonists[edit]

  • GR-64349 - potent and selective agonist, EC50 3.7nM, 7-amino acid polypeptide chain. CAS# 137593-52-3

Antagonists[edit]

See also[edit]

References[edit]

External links[edit]

  • "Tachykinin Receptors: NK2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Tachykinin_receptor_2 — Please support Wikipedia.
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