digplanet beta 1: Athena
Share digplanet:

Agriculture

Applied sciences

Arts

Belief

Business

Chronology

Culture

Education

Environment

Geography

Health

History

Humanities

Language

Law

Life

Mathematics

Nature

People

Politics

Science

Society

Technology

toll-like receptor adaptor molecule 1
Identifiers
Symbol TICAM1
Alt. symbols TRIF
Entrez 148022
HUGO 18348
OMIM 607601
RefSeq NM_014261
UniProt Q8IUC6
Other data
Locus Chr. 19 p13.3

TIR-domain-containing adapter-inducing interferon-β (TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter.[1]

Toll-like receptors (TLRs) recognize specific components of microbial invaders and activate an immune response to these pathogens. After these receptors recognize highly-conserved pathogenic patterns, a downstream signaling cascade is activated in order to stimulate the release of inflammatory cytokines and chemokines as well as to upregulate the expression of immune cells. All TLRs have a TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to a given pathogen.[2]

Structure[edit]

TRIF is primarily active in the spleen and is often regulated when MyD88 is deficient in the liver, indicating organ-specific regulation of signaling pathways. Curiously, there is a lack of redundancy within the TLR4 signaling pathway that leads to microbial evasion of immune response in the host after mutations occur within intermediates of the pathway.[3] Three TRAF-binding motifs present in the amino terminal region of TRIF are necessary for association with TRAF6. Destruction of these motifs reduced the activation of NF-κβ, a transcription factor that is also activated by the carboxy-terminal domain of TRIF in the upregulation of cytokines and co-stimulatory immune molecules. This domain recruits receptor-interacting protein (RIP1) and RIP3 through the RIP homotypic interaction motif. Cells deficient for RIP1 gene display attenuated TLR3 activation of NF-κβ, indicating the use of the RIP1 gene in downstream TRIF activation, in contrast to other TLRs that use IRAK protein for the activation of NF-κβ.[4]

Areas of research[edit]

Investigations into the function of TRIF are of great significance to various fields of biomedical research. The pathogenesis of infectious disease, septic shock, tumor growth, and rheumatoid arthritis all have close ties with TLR signaling pathways, specifically to that of TRIF. Better understanding of the TRIF pathway will be therapeutically useful in the development of vaccines and treatments that can control associated inflammation and antiviral responses. Experiments involving wild-type and TRIF-deficient mice are critical for understanding the coordinated responses of TLR pathways. It is necessary to study the coordinated effects of these pathways in order to understand the complex responses initiated by TRIF.[5]

References[edit]

  1. ^ Palsson-McDermott, Eva and Luke A J O’Neill (2004) Immunology. 113(2) 153-162
  2. ^ Guo B, Cheng G (2007). "Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK". J. Biol. Chem. 282 (16): 11817–26. doi:10.1074/jbc.M700017200. PMID 17327220. 
  3. ^ Palsson-McDermott, Eva and Luke A J O’Neill (2004) Immunology. 113(2) 153-162
  4. ^ Kawai, Taro and Shizuo Akira. (2004). Arthritis Res. Ter. 7(1) 12-19
  5. ^ Ouyang X, Negishi H, Takeda R, Fujita Y, Taniguchi T, Honda K (2007). "Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation". Biochem. Biophys. Res. Commun. 354 (4): 1045–51. doi:10.1016/j.bbrc.2007.01.090. PMID 17275788. 

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/TRIF — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.
17201 videos foundNext > 

Fleshgod Apocalypse - The Violation | Drum Cover by Trif Drums&Girls

Special thanks for sound Мише Лукашову (http://vk.com/lukashov_misha) Sorry, but track played in 260bpm (original - 270)... Because Francesco Paoli is realy crazy drummer!! Cymbals...

Behemoth - Ov Fire And The Void (Drum Cover by TRIF)

My page on facebook - https://www.facebook.com/trif.moscow Второе видео из серии "Drums and Girls". Звук - Александр Богданов (http://vk.com/id1220870)...

MACKLEMORE & RYAN LEWIS - THRIFT SHOP FEAT. WANZ (OFFICIAL VIDEO)

Thrift Shop on iTunes:http://itunes.apple.com/us/album/thrift-shop-feat.-wanz-single/id556955707 The Heist physical deluxe edition: http://www.macklemoremerch.com The Heist digital deluxe on...

Betraying The Martyrs - Tapestry Of Me (Drum Cover by Trif)

My page on facebook - https://www.facebook.com/trif.moscow все, как обычно, делал сам, так что не судите строго. звук по гринде и немного...

Slipknot - Sulfur | Drum Cover by TRIF drums&girls

My page on facebook - https://www.facebook.com/trif.moscow Записано и снято в Hellscream Academy (http://vk.com/hellscream_academy). Sound and video recorded entirely live...

Marius Trif Din cauza ta zambesc

Un produs Raul Uncu&Studiomarkproduction videoclip produs de studiomarkproduction tel. 0722.932.101 Marius Trif tel.0734.537.178.

Marius Trif Eu te as iubi pana in zori

Marius TRIF Tel: 0734.537.178 Productii video de cea mai buna calitate. Marcel FLOREA Tel: 0722.932.101.

FLORINA TRIF - Ăsta-i jocu-n sat la mine

Florina Trif - Foaie verde ca rugu

FLORINA TRIF - Mândră ești Vlădeasă-n lume

17201 videos foundNext > 

1657 news items

Above the Law

Above the Law
Tue, 07 Apr 2015 15:22:29 -0700

At the “after party” Associate Trif told Plaintiff that some attorneys were going to get sushi and that she should join them. When they arrived at the sushi restaurant, Associate Trif admitted to Plaintiff that no one else was joining them because he ...

New Jersey Law Journal

New Jersey Law Journal
Fri, 03 Apr 2015 11:04:40 -0700

Chechelnitsky and Trif began dating, and around the same time, he told her that Modugno had authorized him to assign work to her, the suit claims. Trif regularly bragged about his relationship with Modugno and told Chechelnitsky she would go far if she ...

Madame Noire

Madame Noire
Tue, 14 Apr 2015 13:14:24 -0700

It has been close to a year since Ciara and Future called off their engagement and with the exception of Cici's telling single “I Bet,” the two have remained tight lipped about the split. However, the singer decided to break her silence during a recent ...
 
Journal of Virology
Fri, 03 Apr 2015 08:20:36 -0700

Here, we demonstrate that Tax potently inhibits the activity of DEx(D/H) box helicases RIG-I and MDA5 as well as Toll-dependent TIR-domain-containing adapter-inducing interferon-β (TRIF), which function as cellular sensors or mediators of viral RNA and ...
 
Nature.com
Thu, 02 Apr 2015 23:45:00 -0700

Article | PubMed | ISI | CAS |; Sato N, Takahashi N, Suda K, Nakamura M, Yamaki M, Ninomiya T et al. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha. J Exp Med 2004; 200: 601–611.
 
Journal of Virology
Wed, 26 Mar 2014 08:23:41 -0700

Resveratrol possesses anti-RSV activity and is an inhibitor of the TRIF/TBK1/IRF-3 complex. We hypothesize that resveratrol inhibits the TRIF-dependent pathway through upregulation of SARM post-RSV infection. BALB/c mice were infected with RSV and ...
 
Crain's Chicago Business
Tue, 06 Jan 2015 11:17:38 -0800

A trust affiliated with Trif purchased the complex for about $11.9 million in 2005, according to Cook County property records. Other than some mechanical maintenance, the seller had not done any major renovations on the three-building complex ...

Alto Adige

Alto Adige
Tue, 14 Apr 2015 17:56:15 -0700

Sono così tornate in libertà la tre donne coinvolte nell'operazione. Si tratta di Ana Lavinia Trif ("Blankita"), Mariana Rizea ("Mary") e Florentina Gutuna. Le tre sono accusate a vario titolo di associazione a delinquere volta al favoreggiamento e ...
Loading

Oops, we seem to be having trouble contacting Twitter

Support Wikipedia

A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia. Please add your support for Wikipedia!

Searchlight Group

Digplanet also receives support from Searchlight Group. Visit Searchlight