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Sucralose[1]
Sucralose2.svg
Sucralose-3D-balls.png
Identifiers
CAS number 56038-13-2 YesY
PubChem 71485
ChemSpider 64561 YesY
UNII 96K6UQ3ZD4 YesY
EC number 259-952-2
KEGG C12285 N
Jmol-3D images Image 1
Properties
Molecular formula C12H19Cl3O8
Molar mass 397.64 g/mol
Appearance Off-white to white powder
Odor Odorless
Density 1.69 g/cm3
Melting point 125 °C (257 °F; 398 K)
Solubility in water 283 g/L (20°C)
Acidity (pKa) 12.52±0.70
Hazards
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oil Health code 1: Exposure would cause irritation but only minor residual injury. E.g., turpentine Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references
Comparison of the chemical structures of sucrose (top) and sucralose (bottom)

Sucralose is an artificial sweetener. The majority of ingested sucralose is not broken down by the body, so it is noncaloric.[4] In the European Union, it is also known under the E number (additive code) E955. Sucralose is approximately 320 to 1,000 times as sweet as sucrose (table sugar),[5] twice as sweet as saccharin, and three times as sweet as aspartame. It is stable under heat and over a broad range of pH conditions. Therefore, it can be used in baking or in products that require a longer shelf life. The commercial success of sucralose-based products stems from its favorable comparison to other low-calorie sweeteners in terms of taste, stability, and safety.[6] Common brand names of sucralose-based sweeteners are Splenda, Sukrana, SucraPlus, Candys, Cukren and Nevella.

History[edit]

Sucralose was discovered in 1976 by scientists from Tate & Lyle, working with researchers Leslie Hough and Shashikant Phadnis at Queen Elizabeth College (now part of King's College London).[4] While researching ways to use sucrose and its synthetic derivatives, Phadnis was told to test a chlorinated sugar compound. Phadnis thought Hough asked him to "taste" it, so he did.[7] He found the compound to be exceptionally sweet.

Tate & Lyle patented the substance in 1976; as of 2008, the only remaining patents concern specific manufacturing processes.[8]

Sucralose was first approved for use in Canada in 1991. Subsequent approvals came in Australia in 1993, in New Zealand in 1996, in the United States in 1998, and in the European Union in 2004. By 2008, it had been approved in over 80 countries, including Mexico, Brazil, China, India and Japan.[9] In 2006, the Food and Drug Administration amended the regulations for foods to include sucralose as a non-nutritive sweetener in food.[10] In May 2008, Fusion Nutraceuticals launched a generic product to the market, using Tate & Lyle patents.

Production[edit]

Tate & Lyle currently manufactures sucralose both at a plant in Jurong, Singapore.[11] and at a recently reopened plant in McIntosh, Alabama. It is manufactured by the selective chlorination of sucrose (table sugar), which substitutes three of the hydroxyl groups with chlorine. This chlorination is achieved by selective protection of the primary alcohol groups followed by acetylation and then deprotection of the primary alcohol groups. Following an induced acetyl migration on one of the hydroxyl groups, the partially acetylated sugar is then chlorinated with a chlorinating agent such as phosphorus oxychloride, followed by removal of the acetyl groups to give sucralose.[12]

Product uses[edit]

Sucralose is found in many food and beverage products, used because it is a no-calorie sweetener, does not promote dental cavities,[13] is safe for consumption by diabetics,[14][15][16] and does not affect insulin levels.[17] Sucralose is used as a replacement for, or in combination with, other artificial or natural sweeteners such as aspartame, acesulfame potassium or high-fructose corn syrup. Sucralose is used in products such as candy, breakfast bars and soft drinks. It is also used in canned fruits wherein water and sucralose take the place of much higher calorie corn syrup-based additives. Sucralose mixed with maltodextrin or dextrose (both made from corn) as bulking agents is sold internationally by McNeil Nutritionals under the Splenda brand name. In the United States and Canada, this blend is increasingly found in restaurants, including McDonald's, Tim Hortons and Starbucks, in yellow packets, in contrast to the blue packets commonly used by aspartame and the pink packets used by those containing saccharin sweeteners; in Canada, though, yellow packets are also associated with the SugarTwin brand of cyclamate sweetener.

Cooking[edit]

Sucralose is a highly heat-stable artificial sweetener, allowing it to be used in many recipes with little or no sugar. It is available in a granulated form that allows for same-volume substitution with sugar. This mix of granulated sucralose includes fillers, all of which rapidly dissolve in liquids. While the granulated sucralose provides apparent volume-for-volume sweetness, the texture in baked products may be noticeably different. Sucralose is not hygroscopic, meaning it does not attract moisture, which can lead to baked goods that are noticeably drier and manifesting a less dense texture than those made with sucrose. Unlike sucrose, which melts when baked at high temperatures, sucralose maintains its granular structure when subjected to dry, high heat (e.g., in a 350 °F or 180 °C oven). Furthermore, in its pure state, sucralose begins to decompose into polychlorinated dibenzo-p-dioxins and other highly toxic substances at temperatures above 119 °C or 246 °F.[18][19] Thus, in some baking recipes, such as crème brûlée, which require sugar sprinkled on top to partially or fully melt and crystallize, substituting sucralose will not result in the same surface texture, crispness, or crystalline structure.

Packaging and storage[edit]

Pure sucralose is sold in bulk, but not in quantities suitable for individual use, although some highly concentrated sucralose-water blends are available online, using 1/4 teaspoon per one cup of sweetness or roughly one part sucralose to two parts water.[20] Pure, dry sucralose undergoes some decomposition at elevated temperatures. In solution or blended with maltodextrin, it is slightly more stable. Most products containing sucralose add fillers and additional sweetener to bring the product to the approximate volume and texture of an equivalent amount of sugar.

Effect on caloric content[edit]

Though sucralose itself contains no calories, products that contain fillers, such as maltodextrin and/or dextrose, add about 2-4 calories per teaspoon or individual packet, depending on the product, the fillers used, brand, and the intended use of the product.[21] The US Food and Drug Administration (FDA) allows for any product containing fewer than five calories per serving to be labeled as "zero calories".[22]

Health, safety, and regulation[edit]

Sucralose has been accepted by several national and international food safety regulatory bodies, including the FDA, Joint Food and Agriculture Organization / World Health Organization Expert Committee on Food Additives, the European Union's Scientific Committee on Food, Health Protection Branch of Health and Welfare Canada, and Food Standards Australia New Zealand (FSANZ). According to the Canadian Diabetes Association, the amount of sucralose that can be consumed over a person's lifetime without any adverse effects is 9 milligrams per day per kilogram of body weight.[23][24]

"In determining the safety of sucralose, the FDA reviewed data from more than 110 studies in humans and animals. Many of the studies were designed to identify possible toxic effects, including carcinogenic, reproductive, and neurological effects. No such effects were found, and FDA's approval is based on the finding that sucralose is safe for human consumption." For example, McNeil Nutritional LLC studies submitted as part of its U.S. FDA Food Additive Petition 7A3987 indicated that "in the 2-year rodent bioassays ... there was no evidence of carcinogenic activity for either sucralose or its hydrolysis products ..."[25]

The consumer advocacy group Center for Science in the Public Interest, downgraded sucralose from "Safe" to "Caution" in June 2013, citing a new study linking sucralose consumption with leukemia risk in rats.[26][27][28]

Safety studies[edit]

Results from over 100 animal and clinical studies in the FDA approval process unanimously indicated a lack of risk associated with sucralose intake.[29][30][31][32] However, some adverse effects were seen at doses that significantly exceeded the estimated daily intake (EDI), which is 1.1 mg/kg/day.[33] When the EDI is compared to the intake at which adverse effects are seen—known as the highest no adverse effects limit (HNEL)—at 1500 mg/kg/day,[33] there is a large margin of safety. The bulk of sucralose ingested is not absorbed by the gastrointestinal (GI) tract and is directly excreted in the feces, while 11–27% of it is absorbed.[5] The amount absorbed from the GI tract is largely removed from the blood stream by the kidneys and eliminated in the urine, with 20–30% of the absorbed sucralose being metabolized.[5]

Environmental effects[edit]

According to one study, sucralose is digestible by a number of microorganisms and is broken down once released into the environment.[34] However, measurements by the Swedish Environmental Research Institute have shown wastewater treatment has little effect on sucralose, which is present in wastewater effluents at levels of several μg/l (ppb).[35] There are no known ecotoxicological effects at such levels, but the Swedish Environmental Protection Agency warns there may be a continuous increase in levels if the compound is only slowly degraded in nature.[36]

Other potential effects[edit]

A Duke University study[37] funded by the Sugar Association found evidence that doses of Splenda of between 100 and 1000 mg/kg, containing sucralose at 1.1 to 11 mg/kg (compare to the FDA Acceptable Daily Intake of 5 mg/kg), reduced the amount of fecal microflora in rats by up to 50%, increased the pH level in the intestines, contributed to increases in body weight, and increased levels of P-glycoprotein (P-gp).[38] These effects have not been reported in humans.[5] An expert panel, including scientists from Rutgers University, New York Medical College, Harvard School of Public Health, Columbia University, and Duke University reported in Regulatory Toxicology and Pharmacology that the Duke study was "not scientifically rigorous and is deficient in several critical areas that preclude reliable interpretation of the study results".[39] Another study linked large doses of sucralose, equivalent to 11,450 packets (136 g) per day in a person, to DNA damage in mice.[40] In a small scale study of 17 obese test subjects, sucralose was found to affect glycemic and insulin responses, leading to an increase in peak plasma glucose concentration and insulin secretion rate.[41]

See also[edit]

References[edit]

  1. ^ Merck Index, 11th Edition, 8854.
  2. ^ "sucralose 56038-13-2". The Good Scents Company Information System. Retrieved 30 January 2014. 
  3. ^ Anonymous. Scifinder – Substance Detail for 56038-13-2, October 30, 2010.
  4. ^ a b "All About Sucralose". Calorie Control Council. 
  5. ^ a b c d Michael A. Friedman, Lead Deputy Commissioner for the FDA, Food Additives Permitted for Direct Addition to Food for Human Consumption; Sucralose Federal Register: 21 CFR Part 172, Docket No. 87F-0086, April 3, 1998
  6. ^ A Report on Sucralose from the Food Sanitation Council, The Japan Food Chemical Research Foundation
  7. ^ Gratzer, Walter (28 November 2002). "5. Light on sweetness: the discovery of aspartame". Eurekas and Euphorias: The Oxford Book of Scientific Anecdotes. Oxford University Press. pp. 32–. ISBN 978-0-19-280403-7. Retrieved 1 August 2012. 
  8. ^ "Tate & Lyle loses sucralose patent case". ap-foodtechnology.com. 
  9. ^ "Strong Clinical Database that Supports Safety of Splenda Sweetener Products". McNeil Nutritionals, LLC. Retrieved 2009-12-30. [dead link]
  10. ^ Turner, James (April 3, 2006). "FDA amends regulations that include sucralose as a non-nutritive sweetener in food.". FDA Consumer. Retrieved September 7, 2007. 
  11. ^ Tate & Lyle Sucralose Production Facility Jurong Island, Singapore
  12. ^ U.S. Patent 5,498,709
  13. ^ Food and Drug Administration (2006). "Food labeling: health claims; dietary noncariogenic carbohydrate sweeteners and dental caries.". Federal Register 71 (60): 15559–15564. PMID 16572525. 
  14. ^ Grotz, VL; Henry, RR; McGill, JB; Prince, MJ; Shamoon, H; Trout, JR; Pi-Sunyer, FX (2003). "Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes". Journal of the American Dietetic Association 103 (12): 1607–12. doi:10.1016/j.jada.2003.09.021. PMID 14647086. 
  15. ^ FAP 7A3987, August 16, 1996. pp. 1–357. A 12-week study of the effect of sucralose on glucose homeostasis and HbA1c in normal healthy volunteers, Center for Food Safety and Applied Nutrition, U.S. FDA
  16. ^ Facts About Sucralose, American Dietetic Association, 2006.[dead link]
  17. ^ Ford, HE; Peters, V, Martin, NM, Sleeth, ML, Ghatei, MA, Frost, GS, Bloom, SR (April 2011). "Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects". European journal of clinical nutrition 65 (4): 508–13. doi:10.1038/ejcn.2010.291. PMID 21245879. 
  18. ^ Bannach, Gilbert; Rafael R. Almeida, Luis. G. Lacerda, Egon Schnitzler, Massao Ionashiro (December 2009). "Thermal stability and thermal decomposition of sucralose". Sci. Rep. 34 (4): 21–26. doi:10.1590/S0100-46702009000400002. 
  19. ^ Dong, Shujun; Guorui Liu, Jicheng Hu & Minghui Zheng (October 15, 2013). "Polychlorinated dibenzo-p-dioxins and dibenzofurans formed from sucralose at high temperatures". Scientific Reports 3. doi:10.1038/srep02946. 
  20. ^ Sweetzfree is a clear liquid syrup base, highly concentrated, and made from 100% pure sucralose in a purified water concentrate. http://www.sweetzfree.com/
  21. ^ Filipic, Martha Chow Line: Sucralose sweet for calorie-counters (for 10/3/04) Ohio State Human Nutrition article on sucralose
  22. ^ "CFR – Code of Federal Regulations Title 21". U.S. Food and Drug Administration. 2011-04-01. Retrieved 11 March 2012. 
  23. ^ "Canadian Diabetes Association 2008 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada" (PDF). Canadian Journal of Diabetes (Canadian Diabetes Association) 32 (Supplement 1): S41. September 2008. 
  24. ^ Goldsmith LA (2000). "Acute and subchronic toxicity of sucralose". Food Chem Toxicol. 38 Suppl 2: S53–69. PMID 10882818. 
  25. ^ Food Additives Permitted for Direct Addition to Food for Human Consumption. "Sucralose". FDA Final Rule. United States: Food and Drug Administration. 
  26. ^ [“Food and Drink Police: Center for Science in the Public Interest Wants Government to Control Our Eating Habits,” “Food and Drink Police: Center for Science in the Public Interest Wants Government to Control Our Eating Habits,”].  Missing or empty |title= (help)
  27. ^ "Nutrition Action Health Letter" (PDF). Center for Science in the Public Interest. May 2008. 
  28. ^ "Which additives are safe? Which aren't?". Center for Science in the Public Interest. 
  29. ^ Frank, Genevieve. "Sucralose: An Overview". Penn State University. 
  30. ^ Rodero, A. B.; Rodero, L. S.; Azoubel, R. (2009). "Toxicity of sucralose in humans: a review". Int. J. Morphol. 27 (1): 239–244. 
  31. ^ Grotz VL; Munro IC (2009). "An overview of the safety of sucralose". Regul Toxicol Pharmacol 55 (1): 1–5. doi:10.1016/j.yrtph.2009.05.011. PMID 19464334. 
  32. ^ Grice HC; Goldsmith LA (2000). "Sucralose--an overview of the toxicity data". Food Chem Toxicol 38 (Suppl 2): S1–6. doi:10.1016/S0278-6915(00)00023-5. PMID 10882813. 
  33. ^ a b Baird, I. M.; Shephard, N. W.; Merritt, R. J.; Hildick-Smith, G. (2000). "Repeated dose study of sucralose tolerance in human subjects". Food Chemical Toxicology. 38 (Supplement 2): S123–S129. doi:10.1016/S0278-6915(00)00035-1. PMID 10882825. 
  34. ^ Labare, Michael P; Alexander, Martin (1993). "Biodegradation of sucralose in samples of natural environments". Environmental Toxicology and Chemistry 12 (5): 797–804. doi:10.1897/1552-8618(1993)12[797:BOSACC]2.0.CO;2. 
  35. ^ Measurements of Sucralose in the Swedish Screening Program 2007, Part I; Sucralose in surface waters and STP samples[dead link]
  36. ^ Sötningsmedel sprids till miljön - Naturvårdsverket[dead link]
  37. ^ Browning, Lynnley (2008-09-02). "New Salvo in Splenda Skirmish". The New York Times. Retrieved 2010-05-24. 
  38. ^ Abou-Donia, MB; El-Masry, EM; Abdel-Rahman, AA; McLendon, RE; Schiffman, SS (2008). "Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats". J. Toxicol. Environ. Health Part A 71 (21): 1415–29. doi:10.1080/15287390802328630. PMID 18800291. 
  39. ^ Daniells, Stephen (2009-09-02). "Sucralose safety 'scientifically sound': Expert panel". 
  40. ^ Sasaki, YF; Kawaguchi, S; Kamaya, A; Ohshita, M; Kabasawa, K; Iwama, K; Taniguchi, K; Tsuda, S (2002-08-26). "The comet assay with 8 mouse organs: results with 39 currently used food additives". Mutation Research 519 (1–2): 103–119. doi:10.1016/S1383-5718(02)00128-6. PMID 12160896. 
  41. ^ Pepino, M. Y.; Tiemann, C. D.; Patterson, B. W.; Wice, B. M.; Klein, S. (2013). "Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load". Diabetes Care. doi:10.2337/dc12-2221. PMID 23633524. 

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Sucralose — Please support Wikipedia.
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