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Solifenacin (INN, trade name Vesicare) is a urinary antispasmodic of the antimuscarinic class. It is used in the treatment of overactive bladder with or without urge incontinence. It is manufactured and marketed by Astellas.
Mechanism of action 
Solifenacin is a competitive cholinergic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle. By preventing the binding of acetylcholine to these receptors, solifenacin reduces smooth muscle tone in the bladder, allowing the bladder to retain larger volumes of urine and reducing the number of micturition, urgency and incontinence episodes. Because of a long elimination half life, a once-a-day dose can offer 24 hour control of the urinary bladder smooth muscle tone.
Solifenacin should not be taken by people with a history of previous hypersensitivity to it, urinary retention, gastric retention, uncontrolled or poorly controlled closed-angle glaucoma, or severe liver disease (Child-Pugh class C). It is also contraindicated in long QT syndrome, as solifenacin, like tolterodine and darifenacin, binds to HERG channels and may prolong the QT interval.
Medical uses 
Solifenacin is metabolized in the liver by the cytochrome P450 enzyme CYP3A4. When administered concomitantly with drugs that inhibit CYP3A4, such as ketoconazole, the metabolism of solifenacin is impaired, leading to an increase in its concentration in the body and a reduction in its excretion. The manufacturer recommends that the dosage of solifenacin not exceed 5 mg a day if it is taken with a potent CYP3A4 inhibitor.
As stated above, solifenacin may also prolong the QT interval. Therefore, it should not be administered concomitantly with drugs which also have this effect, such as moxifloxacin or pimozide.
Side effects 
The most common side effects of solifenacin are dry mouth, blurred vision, and constipation. As all anticholinergics, solifenacin may rarely cause heat prostration due to decreased perspiration.
A 2006 cost-effectiveness study found that 5 mg solifenacin had the lowest cost and highest effectiveness among anticholinergic drugs used to treat overactive bladder in the United States, with an average medical cost per successfully treated patient of $6863 per year.
- Agonists: 77-LH-28-1
- SDZ 210-086
Antagonists: 3-Quinuclidinyl Benzilate
- Aclidinium Bromide
- Atropine Methonitrate
- BIBN 99
- Ipratropium bromide
- Mamba Toxin 3
- Mamba Toxin 7
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- N-Methyl-3-Piperidyl Benzilate
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- Zamifenacin; Others: 1st Generation Antihistamines (Brompheniramine
- triprolidine, etc)
- Tricyclic Antidepressants (Amitriptyline
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- Tetracyclic Antidepressants (Amoxapine
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- Typical Antipsychotics (Chlorpromazine
- thioridazine, etc)
- Atypical Antipsychotics (Clozapine
- olanzapine, etc.)
- Agonists: 5-HIAA
- Sazetidine A
- Kynurenic acid
- Methadone (Levomethadone)
- Nitrous Oxide
Solifenacin eases nocturia and may improve sleep-related quality of life
NEW YORK (Reuters Health) - In adults with overactive bladder and nocturia, treatment with solifenacin, may improve quality of sleep and sleep-related qualit...
Generic Solifenacin Availability
Solifenacin (also called Soliten) 5mg and 10mg tablet is used to treat symptoms of an overactive bladder. To buy cheap Vesicare now, please visit: http://www...
How to Pronounce Solifenacin
Learn how to say Solifenacin correctly with EmmaSaying's "how do you pronounce" free tutorials. http://www.emmasaying.com Take a look at my comparison tutori...
Urology Services at the Woodlands - Overactive Bladder
Many men and women suffer from constant "calls of nature." If this looks familiar, you may be suffering from overactive bladder. Ask your Woodlands Urologist...
Buy Vesicare Generic for OAB
Cheap generic Solifenacin (also called Soliten) sale! Get overactive bladder treatment and medications from Big Mounain Pharmacy, visit http://www.bigmountai...
Vesicare TV Ad (2006)
Video # 290: A television advertisement for Vesicare (solifenacin succinate) aired in the US during 2006. Copyright goes to Astellas and GlaxoSmithKline, the...
Vesicare TV Ad (2005)
Video # 12: A television advertisement for Vesicare (solifenacin succinate) aired in the US during 2005. Copyright goes to Astellas and GlaxoSmithKline, the ...
Robotic-Assisted Retropubic Urethrolysis
Pasko, BE, Eltahawy, EA & Marotte JB (2012). Robotic-Assisted Retropubic Urethrolysis. BJUI 2012; volume 110, S3: 1-163 at http://onlinelibrary.wiley.com/doi...
amigos de la nocturia
Thu, 23 May 2013 03:16:15 -0700
Vesomni (formerly known as EC905) is a once-daily, fixed-dose combination of the antimuscarinic solifenacin and alpha blocker tamsulosin, which are both established treatments for men with benign prostatic hyperplasia (BPH). Approval in the Netherlands ...
Thu, 16 May 2013 16:56:33 -0700
The news will be a boost for Japan-based pharma company Astellas, which is touting Betmiga as a successor to Vesicare (solifenacin succinate), the company's current leading overactive bladder treatment. Vesicare is due to lose patent protection in 2018 ...
Tue, 14 May 2013 03:24:30 -0700
For fiscal 2012, revenues grew a little under 4 per cent to 1,000bn yen - driven by immunosupressant Prograf (tacrolimus), Vesicare (solifenacin succinate) for overactive bladder and recently-launched prostate cancer drug Xtandi (enzalutamide) - while ...
MarketWatch (press release)
Mon, 06 May 2013 06:00:55 -0700
In the study, researchers first established concentration-response curves for three different beta3-adrenoceptor agonists (solabegron, CL-316,243, and mirabegron) and three antimuscarinics (oxybutynin, tolterodine, and solifenacin) in a model of ...
PR Newswire (press release)
Tue, 07 May 2013 15:30:57 -0700
The third study, the 12-week Phase 2 Symphony trial, assessed combination therapy of MYRBETRIQ and VESIcare® (solifenacin succinate) versus VESIcare alone. "The pooled analyses represent an important body of evidence supporting MYRBETRIQ as a ...
The Pharma Letter
Wed, 24 Apr 2013 08:36:42 -0700
Sales were up 2% excluding divestments (primarily Vesicare [solifenacin succinate], and non-core OTC brands). Pharmaceuticals and Vaccines sales fell 2%: Geographically, US decreased 6% (+4% excluding Vesicare with strong respiratory and oncology ...
Thu, 23 May 2013 00:22:59 -0700
Jede Tablette enthält 6 mg antimuskarinisches Solifenacin und 0,4 mg Tamsulosin, eines Alpha1-Adrenozeptor-Antagonisten (alpha1-Blocker) (im oralen kontrollierten Aufnahmesystem [OCAS(TM)]) (TOCAS). Phase-III-Daten haben gezeigt, dass VESOMNI ...
Thu, 23 May 2013 15:50:31 -0700
والأدوية المستعملة على أنواع: وهي: - مضادات الكولين Anticholinergic drugs مثل أوكسيبوتينين Oxybutynin (Ditropan)، تولتيرودين Tolterodine (Detrusitol)، سوليفيناسين Solifenacin (Vesicare)، كلوريد تروسبيم Trospium chloride. وهذه الأدوية هي أجيال متلاحقة من ...
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