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"E301" redirects here. For the Japanese train, see EV-E301 series.
Sodium L-ascorbate[1]
Sodium ascorbate.png
Sodium ascorbate powder.jpg
Names
IUPAC name
Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
Other names
Sodascorbate; Monosodium ascorbate; E301
Identifiers
134-03-2 YesY
ChEMBL ChEMBL591665 N
EC number 205-126-1
Jmol-3D images Image
PubChem 23667548
RTECS number CI7671000
Properties
C6H7NaO6
Molar mass 198.11 g·mol−1
Appearance minute white to yellow crystals
Odor odorless
Melting point 218 °C (424 °F; 491 K) (decomposes)
62 g/100mL (25 °C)
78 g/100 mL (75 °C)
Solubility very slightly soluble in alcohol
insoluble in chloroform, ether
Hazards
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g., sodium chloride Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Sodium ascorbate is one of a number of mineral salts of ascorbic acid (vitamin C). The molecular formula of this chemical compound is C6H7NaO6. As the sodium salt of ascorbic acid, it is known as a mineral ascorbate. It has not been demonstrated to be more bioavailable than any other form of vitamin C supplement.[2]

Sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium).

As a food additive, it has the E number E301 and is used as an antioxidant and an acidity regulator. It is approved for use as a food additive in the EU,[3] USA,[4] and Australia and New Zealand.[5]

In in vitro studies, sodium ascorbate has been found to produce cytotoxic effects in various malignant cell lines, which include melanoma cells that are particularly susceptible.[6][7]

Production[edit]

Sodium ascorbate is produced by dissolving ascorbic acid in water and adding an equivalent amount of sodium bicarbonate in water. After cessation of effervescence, the sodium ascorbate is precipitated by the addition of isopropanol.

References[edit]

  1. ^ (+)-Sodium L-ascorbate at Sigma-Aldrich
  2. ^ Linus Pauling Institute, Oregon Stare University: "Bioavailability of Different Forms of Vitamin C". Retrieved 2013-09-27. 
  3. ^ UK Food Standards Agency: "Current EU approved additives and their E Numbers". Retrieved 2011-10-27. 
  4. ^ US Food and Drug Administration: "Listing of Food Additives Status Part II". Retrieved 2011-10-27. 
  5. ^ Australia New Zealand Food Standards Code"Standard 1.2.4 - Labelling of ingredients". Retrieved 2011-10-27. 
  6. ^ Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. (September 2005). "Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues". Proc Natl Acad Sci U S A. 102 (38): 13604–9. doi:10.1073/pnas.0506390102. PMC 1224653. PMID 16157892. 
  7. ^ Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. . (July 2005). "Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake". J Cell Physiol. 204 (1): 192–7. doi:10.1002/jcp.20286. PMID 15672419. 

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Sodium_ascorbate — Please support Wikipedia.
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184 news items

Manila Standard Today

Manila Standard Today
Mon, 25 May 2015 05:22:30 -0700

“Cosmo Cee is especially formulated with sodium ascorbate and citrus bioflavonoids,” notes Nino Bautista of BFPC, adding that bioflavonoids which is present in citrus fruits and green leafy vegetables is another type of Vitamin C that the public is ...

Mondaq News Alerts (registration)

Mondaq News Alerts (registration)
Fri, 01 May 2015 08:40:29 -0700

The Court then affirmed the district court's finding that claim 1 of the '222 patent was infringed based on the district court's finding that sodium ascorbate present in Exela's formulation met the buffering agent limitation as construed by the Court ...
 
Inquirer.net (blog)
Sun, 15 Apr 2012 18:13:45 -0700

UPON my return to the USA from a medical mission in Macebebe, Pampanga, I received an email from a reader, who is a practicing physician in Cebu, inquiring about the efficacy and safety of sodium ascorbate, which I know is widely advertised as ...
 
PR.com (press release)
Sun, 03 Apr 2011 10:29:59 -0700

Vitamin C Foundation Approved® Sodium Ascorbate is now available. Their sodium ascorbate is made from DSM Nutritional Products Quali-C® manufactured in Europe. The fine powder is non-acidic, hypoallergenic, GMO-free, and 100% corn free.
 
KGAN TV
Tue, 14 Apr 2015 20:01:21 -0700

IOWA CITY, IA (CBS2/FOX28) - Researchers at the University of Iowa Hospitals and Clinics say what they witnessed was just too promising, they had to set aside the prestige and respect for the Mayo Clinic in Minnesota and go with their gut to explore an ...
 
MarketWatch
Mon, 02 Mar 2015 13:00:00 -0800

Salix markets XIFAXAN® (rifaximin) tablets 200 mg and 550 mg, MOVIPREP® (PEG 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid for oral solution, 100 g/7.5 g/2.691 g/1.015 g/5.9 g/4.7 g), OSMOPREP® ...
 
Huffington Post
Tue, 21 Oct 2014 09:17:00 -0700

WASHINGTON (AP) — People who shared an apartment with the country's first Ebola patient are emerging from quarantine healthy. And while Thomas Eric Duncan died and two U.S. nurses were infected caring for him, there are successes, too: A nurse ...

USA TODAY

USA TODAY
Tue, 30 Sep 2014 22:41:48 -0700

DALLAS — Three Dallas Fire-Rescue paramedics and several emergency room workers at Texas Health Presbyterian Hospital are off work and under observation after making contact with the patient being treated for Ebola. None of the individuals has been ...
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