|Jmol-3D images||Image 1|
|Molar mass||198.11 g mol−1|
|Appearance||minute white to yellow crystals|
218 °C, 491 K, 424 °F (decomp)
|Solubility in water||62 g/100mL (25 °C)
78 g/100 mL (75 °C)
|Solubility||very slightly soluble in alcohol
insoluble in chloroform, ether
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Sodium ascorbate is one of a number of mineral salts of ascorbic acid (vitamin C). The molecular formula of this chemical compound is C6H7NaO6. As the sodium salt of ascorbic acid, it is known as a mineral ascorbate. It has not been demonstrated to be more bioavailable than any other form of vitamin C supplement.
Sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium).
Sodium ascorbate may play a role in the elimination of chronic and acute infections[according to whom?]. In the laboratory, it has produced cytotoxic effect in various malignant cell lines, which include melanoma cells that are particularly susceptible.
Sodium ascorbate is produced by dissolving ascorbic acid in water and adding an equivalent amount of [sodium bicarbonate] in water. After cessation of effervescence, the sodium ascorbate is precipitated by the addition of isopropanol.
Side-effects of sodium ascorbate
While sodium ascorbate is relatively safe, its extensive intake may lead to several side-effects. The common side-effects that persist or become troublesome when using sodium ascorbate, especially in a liquid form as injections, include burning, stinging, pain, or swelling at the injection site. Severe allergic reactions include rash; itching; difficult breathing; hives; tightness in the chest; swelling of the mouth, face, lips, or tongue; bone pain; muscle weakness; severe or persistent diarrhea; mental or mood changes.
- (+)-Sodium L-ascorbate at Sigma-Aldrich
- Linus Pauling Institute, Oregon Stare University: "Bioavailability of Different Forms of Vitamin C". Retrieved 2013-09-27.
- UK Food Standards Agency: "Current EU approved additives and their E Numbers". Retrieved 2011-10-27.
- US Food and Drug Administration: "Listing of Food Additives Status Part II". Retrieved 2011-10-27.
- Australia New Zealand Food Standards Code"Standard 1.2.4 - Labelling of ingredients". Retrieved 2011-10-27.
- Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. (September 2005). "Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues". Proc Natl Acad Sci U S A. 102 (38): 13604–9. doi:10.1073/pnas.0506390102. PMC 1224653. PMID 16157892.
- Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. . (July 2005). "Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake". J Cell Physiol. 204 (1): 192–7. doi:10.1002/jcp.20286. PMID 15672419.
- Frederick R. Klenner, Lendon H. Smith (October 1991). Clinical Guide to the Use of Vitamin C: The Clinical Experiences of Frederick R. Klenner, M.D. (Clinical Guide to the Use of Vitamin C: Abbreviated, Summarized and Annotated by Lendon H. Smith, M.D. ed.). Tacoma, Wash: Life Sciences Press. ISBN 978-0-943685-13-7.