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"E301" redirects here. For the Japanese train, see EV-E301 series.
Sodium L-ascorbate[1]
Sodium ascorbate.png
Sodium ascorbate powder.jpg
Names
IUPAC name
Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
Other names
Sodascorbate; Monosodium ascorbate; E301
Identifiers
134-03-2 YesY
ChEMBL ChEMBL591665 N
EC number 205-126-1
Jmol-3D images Image
PubChem 23667548
RTECS number CI7671000
Properties
C6H7NaO6
Molar mass 198.11 g·mol−1
Appearance minute white to yellow crystals
Odor odorless
Melting point 218 °C (424 °F; 491 K) (decomposes)
62 g/100mL (25 °C)
78 g/100 mL (75 °C)
Solubility very slightly soluble in alcohol
insoluble in chloroform, ether
Hazards
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g., sodium chloride Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Sodium ascorbate is one of a number of mineral salts of ascorbic acid (vitamin C). The molecular formula of this chemical compound is C6H7NaO6. As the sodium salt of ascorbic acid, it is known as a mineral ascorbate. It has not been demonstrated to be more bioavailable than any other form of vitamin C supplement.[2]

Sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium).

As a food additive, it has the E number E301 and is used as an antioxidant and an acidity regulator. It is approved for use as a food additive in the EU,[3] USA,[4] and Australia and New Zealand.[5]

In in vitro studies, sodium ascorbate has been found to produce cytotoxic effects in various malignant cell lines, which include melanoma cells that are particularly susceptible.[6][7]

Production[edit]

Sodium ascorbate is produced by dissolving ascorbic acid in water and adding an equivalent amount of sodium bicarbonate in water. After cessation of effervescence, the sodium ascorbate is precipitated by the addition of isopropanol.

References[edit]

  1. ^ (+)-Sodium L-ascorbate at Sigma-Aldrich
  2. ^ Linus Pauling Institute, Oregon Stare University: "Bioavailability of Different Forms of Vitamin C". Retrieved 2013-09-27. 
  3. ^ UK Food Standards Agency: "Current EU approved additives and their E Numbers". Retrieved 2011-10-27. 
  4. ^ US Food and Drug Administration: "Listing of Food Additives Status Part II". Retrieved 2011-10-27. 
  5. ^ Australia New Zealand Food Standards Code"Standard 1.2.4 - Labelling of ingredients". Retrieved 2011-10-27. 
  6. ^ Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. (September 2005). "Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues". Proc Natl Acad Sci U S A. 102 (38): 13604–9. doi:10.1073/pnas.0506390102. PMC 1224653. PMID 16157892. 
  7. ^ Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. . (July 2005). "Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake". J Cell Physiol. 204 (1): 192–7. doi:10.1002/jcp.20286. PMID 15672419. 

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Sodium_ascorbate — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.
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171 news items

 
Inquirer.net
Mon, 30 Mar 2015 10:26:15 -0700

Vitamin C: Increase your intake of Vitamin C, whether calcium ascorbate or sodium ascorbate—1,000-3,000 milligrams every day. Avoid the sun: Protect yourself if you can't avoid exposing yourself to the sun. Non-negotiable: No sun exposure from 10 a.m ...
 
JD Supra (press release)
Thu, 26 Mar 2015 23:22:30 -0700

With this construction the opinion found substantial evidence that "the sodium ascorbate present in Exela's formulation as an antioxidant met the buffering agent limitation, as correctly construed" and affirmed the judgment of literal infringement of ...
 
MarketWatch
Mon, 02 Mar 2015 13:03:15 -0800

Salix markets XIFAXAN® (rifaximin) tablets 200 mg and 550 mg, MOVIPREP® (PEG 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate and ascorbic acid for oral solution, 100 g/7.5 g/2.691 g/1.015 g/5.9 g/4.7 g), OSMOPREP® ...

Zambia Daily Mail

Zambia Daily Mail
Wed, 18 Mar 2015 01:32:33 -0700

Other ingredients in some common cereals include high fructose corn syrup, salt, honey, malt flavouring, alpha tocopherol acetate [vitamin E], niacinamide, zinc oxide, reduced iron, sodium ascorbate and ascorbic acid (vitamin C) and calcium ...
 
Inquirer.net (blog)
Sun, 15 Apr 2012 18:13:45 -0700

UPON my return to the USA from a medical mission in Macebebe, Pampanga, I received an email from a reader, who is a practicing physician in Cebu, inquiring about the efficacy and safety of sodium ascorbate, which I know is widely advertised as ...
 
PR.com (press release)
Sun, 03 Apr 2011 10:29:59 -0700

Vitamin C Foundation Approved® Sodium Ascorbate is now available. Their sodium ascorbate is made from DSM Nutritional Products Quali-C® manufactured in Europe. The fine powder is non-acidic, hypoallergenic, GMO-free, and 100% corn free.
 
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Wed, 07 Jan 2015 18:48:45 -0800

The strategy is to take high doses of sodium ascorbate. Please note it is extremely important that you utilize sodium ascorbate and not calcium or potassium ascorbate forms. This is because the necessary dosing levels can be high enough that these ...
 
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WASHINGTON (AP) — People who shared an apartment with the country's first Ebola patient are emerging from quarantine healthy. And while Thomas Eric Duncan died and two U.S. nurses were infected caring for him, there are successes, too: A nurse ...
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