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"E301" redirects here. For the Japanese train, see EV-E301 series.
Sodium L-ascorbate[1]
Sodium ascorbate.png
Sodium ascorbate powder.jpg
Names
IUPAC name
Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate
Other names
Sodascorbate; Monosodium ascorbate; E301
Identifiers
134-03-2 YesY
ChEMBL ChEMBL591665 N
EC number 205-126-1
Jmol-3D images Image
PubChem 23667548
RTECS number CI7671000
UNII S033EH8359 N
Properties
C6H7NaO6
Molar mass 198.11 g·mol−1
Appearance minute white to yellow crystals
Odor odorless
Melting point 218 °C (424 °F; 491 K) (decomposes)
62 g/100 mL (25 °C)
78 g/100 mL (75 °C)
Solubility very slightly soluble in alcohol
insoluble in chloroform, ether
Hazards
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 0: Exposure under fire conditions would offer no hazard beyond that of ordinary combustible material. E.g., sodium chloride Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Sodium ascorbate is one of a number of mineral salts of ascorbic acid (vitamin C). The molecular formula of this chemical compound is C6H7NaO6. As the sodium salt of ascorbic acid, it is known as a mineral ascorbate. It has not been demonstrated to be more bioavailable than any other form of vitamin C supplement.[2]

Sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium).

As a food additive, it has the E number E301 and is used as an antioxidant and an acidity regulator. It is approved for use as a food additive in the EU,[3] USA,[4] and Australia and New Zealand.[5]

In in vitro studies, sodium ascorbate has been found to produce cytotoxic effects in various malignant cell lines, which include melanoma cells that are particularly susceptible.[6][7]

Production[edit]

Sodium ascorbate is produced by dissolving ascorbic acid in water and adding an equivalent amount of sodium bicarbonate in water. After cessation of effervescence, the sodium ascorbate is precipitated by the addition of isopropanol.

References[edit]

  1. ^ (+)-Sodium L-ascorbate at Sigma-Aldrich
  2. ^ Linus Pauling Institute, Oregon Stare University: "Bioavailability of Different Forms of Vitamin C". Retrieved 2013-09-27. 
  3. ^ UK Food Standards Agency: "Current EU approved additives and their E Numbers". Retrieved 2011-10-27. 
  4. ^ US Food and Drug Administration: "Listing of Food Additives Status Part II". Retrieved 2011-10-27. 
  5. ^ Australia New Zealand Food Standards Code"Standard 1.2.4 - Labelling of ingredients". Retrieved 2011-10-27. 
  6. ^ Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. (September 2005). "Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues". Proc Natl Acad Sci U S A. 102 (38): 13604–9. doi:10.1073/pnas.0506390102. PMC 1224653. PMID 16157892. 
  7. ^ Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ. . (July 2005). "Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake". J Cell Physiol. 204 (1): 192–7. doi:10.1002/jcp.20286. PMID 15672419. 

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Sodium_ascorbate — Please support Wikipedia.
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165 news items

The Globe and Mail

The Globe and Mail
Mon, 17 Aug 2015 12:11:56 -0700

Unless you grow your own food and prepare all your meals from scratch, it's pretty much impossible to eat foods that don't have chemical additives. You'll find caramel colour in bread, xanthan gum in salad dressings, carrageenan in almond milk ...
 
Huffington Post
Wed, 05 Aug 2015 12:41:15 -0700

... alpha tocopherol acetate [vitamin E], niacinamide, zinc oxide, reduced iron, sodium ascorbate and ascorbic acid (vitamin C), calcium pantothenate, Yellow #5, pyridoxine hydrochloride (vitamin B6), riboflavin (vitamin B2), thiamin hydrochloride ...
 
MENAFN.COM
Wed, 29 Jul 2015 01:37:30 -0700

The Global Sodium Ascorbate Industry Report 2015 is a professional and in-depth study on the current state of the Sodium Ascorbate industry. The report provides a basic overview of the industry including definitions classifications applications and ...
 
Inquirer.net (blog)
Sun, 15 Apr 2012 18:07:30 -0700

UPON my return to the USA from a medical mission in Macebebe, Pampanga, I received an email from a reader, who is a practicing physician in Cebu, inquiring about the efficacy and safety of sodium ascorbate, which I know is widely advertised as ...

Science 2.0

Science 2.0
Mon, 18 May 2015 07:31:11 -0700

The diagnosis of the first case of Ebola in Lagos, Nigeria in July last year set off alarm bells around the world. The fear was that it would trigger an apocalyptic epidemic that would make the outbreaks in Liberia, Sierra-Leone and Guinea, where 1322 ...
 
PR.com (press release)
Sun, 03 Apr 2011 10:29:59 -0700

Vitamin C Foundation Approved® Sodium Ascorbate is now available. Their sodium ascorbate is made from DSM Nutritional Products Quali-C® manufactured in Europe. The fine powder is non-acidic, hypoallergenic, GMO-free, and 100% corn free.

PR Web (press release)

PR Web (press release)
Tue, 07 Apr 2015 00:06:44 -0700

According to the world expert, the late Robert Cathcart III, MD, the sterility of the stock solution did not worry him “because sodium ascorbate in solution is very bactericidal.” Therefore, there is nothing better than vitamin C itself to sterilize ...

Philippine Star

Philippine Star
Thu, 18 Jun 2015 08:57:56 -0700

... Cosmo Cee, touted to be “the healthier Vitamin C alternative” which is, according to Nino Bautista, director of BFPC (Bargn Farmaceutical Pilippines Company), the brand's manufacturer, “especially formulated with sodium ascorbate and citrus ...
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