Sirio is a low-floor tram built by Ansaldobreda
Sirio may also refer to:
- Sirio Carrapa, an Italian mystic
- Sirio Maccioni, a restaurateur and author based in New York City
- Sirio, a brand of engines by Italian American Motor Engineering
- SS Sirio. The name of an Italian immigrant transporter ship, wrecked off Cartagena in 1906
See also: Sirius (disambiguation)
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