||This article needs additional citations for verification. (August 2010)|
|President||John F. Williams, MD, EdD, MPH|
|Other students||1,040 residents|
|Location||Brooklyn, New York
SUNY Downstate Medical Center, located in central Brooklyn, New York, is the only academic medical center for health education, research, and patient care serving Brooklyn’s 2.5 million residents. As of Fall 2011, it had a total student body of 1,738 and approximately 8,000 faculty and staff.
Downstate Medical Center comprises a College of Medicine, Colleges of Nursing and Health Related Professions, Schools of Graduate Studies and Public Health, and University Hospital of Brooklyn. It also includes a major research complex and biotechnology facilities.
SUNY Downstate ranks eighth nationally in the number of alumni who are on the faculty of American medical schools. More physicians practicing in New York City graduated from Downstate than from any other medical school. With 1,040 residents (young physicians in training), Downstate's residency program is the 16th largest in the country.
SUNY Downstate Medical Center is the fourth largest employer in Brooklyn. Eighty-six percent of its employees are New York City residents; 68 percent live in Brooklyn. The medical center's total direct, indirect, and induced economic impact on New York State is in excess of $2 billion. SUNY Downstate Medical Center attracted close to $60 million in external research funding in 2011, which includes $26 million from federal sources. It ranks fourth among SUNY campuses in grant expenditures, and second among SUNY's academic health centers.
In 2010 SUNY Downstate celebrated its sesquicentennial, commemorating the year that the Long Island College Hospital (as it was then known) first opened its doors to students. Yet Downstate traces its roots back even further (to 1856) when a small group of physicians set up a free dispensary in Brooklyn to care for poor immigrants.
Known as the German General Dispensary, its original aim was to care for indigent Germans living in Brooklyn, but changing demographics soon required it to broaden its outreach. In 1857 it was reorganized as a charitable institution and renamed The St. John’s Hospital—the first of many name changes.
Officially chartered by the state in 1858 as the Long Island College Hospital of the City of Brooklyn, it was authorized to operate a hospital and confer medical degrees on candidates who attended two lecture courses and completed a three-year preceptorship under a practicing physician. The notion that care at the hospital bedside should be included as an essential part of medical training was revolutionary for its time, but other medical schools soon adopted the approach and it came to be regarded as essential pedagogy.
In 1860 the school officially opened its doors to 57 (male) students. It was one of only 11 medical schools to admit African American students. The first faculty included many distinguished physicians, such as Dr. Austin Flint, Sr., remembered for his role in introducing the stethoscope into standard medical practice in this country. Dr. Flint delivered the commencement address on July 24, 1860, when the school graduated its first new doctors.
In the following decades The Long Island College Hospital greatly expanded both its facilities and medical school curriculum. By the time of the First World War, admission was opened to women and postgraduate training had been introduced. In 1930 the college and hospital were separated from one another so that each would be under its own governing board. The following year, the school was rechartered as the Long Island College of Medicine.
In 1945, the college purchased a large tract of land that would become the site of the future Downstate Medical Center. The “Downstate” era began on April 5, 1950, with the signing of a merger contract between the State University of New York (SUNY) and the Long Island College of Medicine. The medical center came to be known as Downstate to distinguish it from the SUNY medical center in Syracuse, New York, which is known as “Upstate.” Several years later the current campus was built in the East Flatbush section of Brooklyn.
In 1954 President Dwight D. Eisenhower laid the cornerstone for the Basic Sciences Building. In the following years, the complex grew rapidly, with the addition of a student center and residence halls, as well as a nurses' residence. In 1966 Governor Nelson Rockefeller officiated at the dedication of University Hospital of Brooklyn (UHB), Downstate’s own teaching hospital. The School of Graduate Studies, the College of Health Related Professions, and the College of Nursing were established that same year. In 1987 Governor Mario Cuomo and Mayor Edward Koch helped break ground for the new Health Science Education Building, where most student classes now take place.
More recently, the medical center has entered a period of renewed growth and expansion. In addition to the completion of a multimillion dollar capital improvement program for the hospital and new clinical and research facilities, the campus has expanded to include a Biotechnology Park and Advanced Biotechnology Incubator, and School of Public Health.
The Advanced Biotechnology Incubator, designed for start-up and early-stage biotech companies, includes a commercial synthetic chemistry facility. Construction is underway to develop biotech research and manufacturing at the Brooklyn Army Terminal. These initiatives are part of a strategic plan to position SUNY Downstate as the center for biomedical discovery and development in Brooklyn.
Academic profile 
SUNY Downstate offers students a broad professional education that prepares them for practice or careers in any location and community. The vast majority of students are drawn from the New York City metropolitan area. Many have immigrant backgrounds and are members of racial and cultural groups who are underrepresented in the health professions. The differences in background and outlook enhance the quality of the educational experience of all students.
Downstate's Colleges of Medicine, Nursing, and Health Related Professions and its School of Graduate Studies and School of Public Health collectively offer more than 30 health-focused programs. Statistical profiles of each of the colleges and schools can be found at http://sls.downstate.edu/institutional_research/statistical_portraits/2010/html/.
College of Medicine
The College of Medicine, which grants the MD degree, is the 32nd oldest college of medicine in the country. With approximately 800 enrollees, it is one of the largest colleges of medicine in New York State. It ranks eighth out of 140 accredited medical schools in the nation in the number of alumni who hold faculty positions at U.S. medical schools. More physicians practicing in New York City graduated from Downstate's College of Medicine than from any other medical school.
In addition to granting the MD degree, the College sponsors a combined MD/PhD degree with the School of Graduate Studies.
School of Graduate Studies
Of the School's three multidisciplinary core programs, Neural and Behavioral Science is the oldest. Faculty research in the neurosciences is especially deep, ranging from the molecular to the behavioral. The Program in Molecular and Cellular Biology has concentrations in cardiovascular, fundamental cellular and molecular biology, cancer biology, and more. The Program in Biomedical Engineering, run jointly with the Polytechnic Institute of NYU, features concentrations in neurorobotics, imaging, and materials.
The School of Graduate Studies has also partnered with the College of Nanoscale Science and Engineering (CSNE) of the University at Albany to offer a combined MD/PhD degree program in nanoscale medicine. This clinical scientist education program provides hands-on training in the development and application of nanotechnology to advance health care. MD training at Downstate is coupled with PhD training in either nanoscale science or nanoscale engineering.
- Molecular and Cellular Biology
- Neural and Behavioral Science
- Biomedical Engineering
School of Public Health
The first new school established at SUNY Downstate since 1966, it was launched in 2001 as an MPH degree program within the Department of Preventive Medicine and Community Health in the College of Medicine. In 2008 it declared school status and was fully accredited by the Council on Education for Public Health in 2010. It currently offers five master's and three doctoral programs, as well as combined degree programs.
MPH and DrPH Programs
- Biostatistics (MPH only)
- Community Health Sciences
- Environmental and Occupational Health Sciences
- Health Policy and Management (MPH only)
College of Health Related Professions
An upper-division undergraduate and graduate school, the College has graduated close to 4,000 allied health professionals since its establishment in 1966. Approximately 80 percent of students have four-year college degrees in other fields upon enrollment. Its direct-entry midwifery program was the first of its kind in the nation.
- Diagnostic Medical Imaging
- Physician Assistant
- Medical Informatics
- Occupational Therapy
- BS/DPT in Physical Therapy
Advanced Certificate Programs:
College of Nursing
The College offers an undergraduate, upper-division RN-to-BS degree program for students who are already licensed as professional nurses and an Accelerated BS program for students who hold a degree in another field and seek basic preparation for beginning nursing practice. The College is one of only four nursing schools in New York State to offer master's degree programs in all advanced nursing practice roles.
- RN to BS
- Accelerated BS
- Nursing (Clinical Nurse Specialist)
- Family Nurse Practitioner
- Women’s Health Nurse Practitioner
- Nurse Anesthesia
- Nurse Midwifery
Advanced Certificate Programs:
- Family Nurse Practitioner
- Women’s Primary Care Nurse Practitioner
Patient care 
Downstate's University Hospital of Brooklyn (UHB) offers comprehensive, advanced medical care throughout Brooklyn. It includes two full-service, comprehensive hospital sites (UHB at Central Brooklyn and UHB at Long Island College Hospital) plus a free-standing Urgent Care and Ambulatory Surgery Center in Bay Ridge and nine ambulatory satellite sites. UHB is licensed for 882 beds and annually provides care to over 300,000 patients. In 2012, Consumer Reports ranked University Hospital as the safest hospital in Brooklyn.
University Hospital of Brooklyn at Central Brooklyn http://www.downstate.edu/health-care.html is an 8-story facility with 8 intensive care and step-down units, 12 operating rooms, an adult and pediatric ER, diagnostic and ambulatory surgery facility, and 75 outpatient clinics. The flagship location for UHB, Central Brooklyn includes three community-based health centers in the neighborhoods of East New York, Bedford-Stuyvesant, and Midwood, plus a freestanding Dialysis Center.
- Comprehensive cardiovascular services, including 24/7 angioplasty services and heart surgery;
- Comprehensive neurological services, including neurosurgery, diagnosis and treatment for stroke, epilepsy, sleep disorders, and Alzheimer’s disease;
- Adult/pediatric emergency services: the ER receives more than 68,906 patient visits a year [2010 data for University Hospital Central Brooklyn location];
- Kidney transplantation and dialysis – the only transplant and pediatric dialysis centers in Brooklyn.
- Sports medicine;
- HIV/AIDS treatment and support services — Downstate is a designated AIDS treatment center;
- Maternal and infant health—Downstate is a designated Regional Perinatal Center.
University Hospital of Brooklyn at Long Island College Hospital (UHB at LICH)  is located in Brooklyn Heights/Cobble Hill. LICH merged with Downstate in the Spring of 2011. On February 8, 2013, the SUNY Board of Trustees voted "to support a decision by SUNY Downstate Medical Center leadership to seek approval from the state Department of Health to cease operation of [LICH] as a full-service inpatient hospital facility."
- Othmer Cancer Center
- Comprehensive Stroke Center
- Pediatric and obstetric services
- Ambulance service that is part of the NYC 911 emergency dispatch system
SUNY Downstate at Bay Ridge http://www.downstate.edu/bayridge/ serves the communities of Bay Ridge/Dyker Heights, Bensonhurst, and Sunset Park. It features a walk-in Urgent Care Center, Ambulatory Surgery Center, Advanced Endoscopy Center, and Laser Vision Correction Center. It has onsite laboratory and radiology diagnostic facilities and medical offices for doctors in many clinical specialties.
SUNY Downstate is an important research facility where scientists and clinicians explore many urgent health problems. Historically, areas of research strength include cardiovascular biology, neuroscience, and instrumentation. Current strengths include learning and memory mechanisms; pathogenesis of atherosclerosis and cardiomyopathy; robotic prosthetic devices; HIV/AIDS; pain and addiction; optical tomography imaging technology; and fundamental cell biology (mechanisms of transcription and translation).
Downstate’s role as the only academic medical center in Brooklyn is central to its powerful role in clinical, translational, and public health research. Downstate’s research spans the entire “bench to bedside” spectrum as an integrated entity, bringing together basic scientists, clinical researchers, and practitioners with common interests.
Downstate is the fourth highest grant recipient of SUNY’s 64 campuses. In FY 2011, sponsored research programs, including those funded by the National Institutes of Health (NIH), DARPA, and private foundations, totaled over $60 million. Downstate is the only healthcare facility in Brooklyn that holds the Nobel Prize in Medicine or Physiology.
Notable Faculty and Achievements
- Austin Flint, MD - championed the use of the stethoscope in the United States (1860s).
- Frank Hamilton, MD - first advocate of skin grafting and a leading authority on fractures (1860s).
- John Call Dalton, MD - first in this country to teach physiology by conducting experiments on animals (1860s).
- George Sternberg, MD - pioneering immunologist, first to demonstrate the bacillus of typhoid fever (1880s).
- Alexander Skene, MD - authority on women’s diseases; discovered the paraurethral glands known as Skene’s ducts (1880).
- Robert L. Dickinson, MD - published first “modern” pamphlet on voluntary birth control (1931).
- Alfred Adler, MD - coins the phrase, “inferiority complex” (1930s).
- Jean Redman Oliver, MD - morphology, pathology, and metabolism of kidneys (1930s).
- Clarence Dennis, MD, PhD – performed first successful open-heart surgery in New York State (1955).
- Chandler McCuskey Brooks, PhD - the Graduate School’s founder, laid much of the groundwork in spinal cord and hypothalamic physiology, and cardiac pacemaker function (1950s).
- Eli Friedman, MD - established nation's first federally funded dialysis program (1964) and invented portable dialysis machine (1973).
- Samuel Kountz, MD – first African American transplant surgeon (1970s).
- Hugh Carroll, MD – described mechanisms of hyperglycemic nonketotic coma (1972).
- Raymond Damadian, MD - produced first human images using magnetic resonance imaging using a machine he constructed at Downstate (1977).
- Jeffrey Borer, MD - developed stress radionuclide cineangiography to diagnose heart abnormalities while patients exercise (1977-)
- Henri Begleiter, PhD - published landmark study showing that children of alcoholics may have a genetic risk for alcoholism (1984).
- Sheldon Landesman, MD - conducted early study of HIV infection in women; Downstate conducted first federally funded study of HIV transmission from mother to fetus (1986).
- Brendan Lee, MD, PhD - discovered gene responsible for Marfan’s syndrome (1991)
- Robert Furchgott, PhD - awarded Nobel Prize in Medicine or Physiology for research on nitric oxide (1998)
- Frank Gress, MD - pioneered special instruments and techniques used in endoscopic ultrasonography to diagnose and treat pancreatic cancer (2000-)
- Todd Sacktor, MD, and Andre Fenton, PhD - identified the memory-preserving protein, PKMzeta, and found that ZIP, a chemical compound that inhibits PKMzeta, can erase memories. Named one of top 10 science breakthroughs of 2006 by Science magazine.
- John C. LaRosa, MD - principal investigator for Treating to New Targets Study, showed that using statins to intensively lower LDL cholesterol in patients with stable coronary disease reduces the risk of heart attack and stroke (2005).
- Olcay Batuman, MD - found that MAL3-101, a recently developed inhibitor of the heat shock protein 70, has potent anti-tumor effects on multiple myeloma (2000s).
- Joseph Francis, PhD - developing a computer-enabled, brain-machine interface to allow individuals to mentally control prosthetic limbs (2000s).
- John Chapin, PhD, and Joe Francis, PhD - created "robo rats" that can be controlled remotely by signals sent to their brain for potential use to locate explosives or find survivors at disaster sites (2000s).
- Randall Barbour, PhD - developed methods and instrumentation for imaging human tissue by optical tomography, a nonionizing diagnostic tool (2000s).
- Helen Durkin, PhD - discovered drug that blocks the production of Immunoglobulin E, an antibody that causes reactions in people with asthma and food allergies (2000s).
- Douglas Lazzaro, MD - has attracted $6.2 million in funding for eye research in the past five years; now principal investigator of a new study supported by Research to Prevent Blindness. Team members William Brunken, PhD, and Brahim Chaqour, PhD, are studying retinal disease; John Danias, MD, PhD, is researching glaucoma; and Jacob Aranda, MD, PhD, has received major funding from the National Institutes of Child Health and Human Development to establish a pediatric pharmacology center focused on preventing retinopathy in premature infants (2000s).
- Matthew Pincus, MD, PhD, and Josef Michl, MD - developed a peptide, PNC-28, that effectively destroys pancreatic tumor cells in laboratory studies (2000s).
- Bernice Porsjcz - $35 million grant from NIAAA for genetics of alcoholism research.
- Edward Quadros, PhD - created a clinical test to diagnose the risk of folate-related problems in women that can lead to subfertility, neural tube birth defects, cerebral folate deficiency in infants, and autism spectrum disorders (2000s).
- Sheryl Smith, PhD - showed that the neurotransmitter receptor GABAa causes adolescents to become more anxious in the face of stress compared to young children or adults (2000s).
- Henri Tiedge, PhD - researching how drugs of abuse, such as opiates, impact neuronal RNA translation (2000s).
Research centers and major laboratories
- Alzheimer’s Disease Research Program
- Brooklyn Center for Health Disparities
- Center for Biomedical Imaging
- Center for Cardiovascular Muscle Research
- Center for Neurorobotics and Neuroengineering
- Center for Treatment and Study of Endometriosis
- Cancer Research Focus Group
- Henri Begleiter Neurodynamics Laboratory (Genetics of Alcoholism)
- HIV Center for Women and Children
- Northeast Terrorism Preparedness, Training, Education, and Research Center
- Transgenic Mouse Core Facility
References in popular culture 
- Mos Def, in his 1999 recording of "Got" uses the line "you takin' a ride on the Downstate Medical," indicating that the victim of a violent robbery might be transported by ambulance to SUNY Downstate to receive medical care.
- "Facts About SUNY Downstate". 2010-04-28. Retrieved 2010-10-02.
- "SUNY Board Approves Recommended Closure of Long Island College Hospital". SUNY Press release. 8 February 2013. Retrieved 9 February 2013.
- Official Site
- SUNY Downstate Library Resources
- Brooklyn College B.A.-M.D. Program
- Clarence Dennis Papers (1927-2003) - National Library of Medicine finding aid
- The Clarence Dennis Collection - Profiles in Science, National Library of Medicine
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