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CAS number 153-18-4 YesY
PubChem 5280805
ChemSpider 4444362 N
DrugBank DB01698
KEGG C05625 N
RTECS number VM2975000
ATC code C05CA01
Jmol-3D images Image 1
Molecular formula C27H30O16
Molar mass 610.52 g mol−1
Appearance Solid
Melting point 242 °C (468 °F; 515 K)
Solubility in water 12.5 mg/100 mL[1]
13 mg/100mL[2]
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Rutin, also called rutoside, quercetin-3-O-rutinoside and sophorin, is the glycoside between the flavonol quercetin and the disaccharide rutinose (α-L-rhamnopyranosyl-(1→6))-β-D-glucopyranose). In the fava d'anta tree, the synthesis is done via a rutin synthase activity.[3]


Rutin is one of the phenolic compounds found in the invasive plant species Carpobrotus edulis and contributes to the antibacterial[4] and antioxidant[5] properties of the plant.

Its name comes from the name of Ruta graveolens, a plant that also contains rutin.

In food[edit]

Rutin is a citrus flavonoid glycoside found in many plants including buckwheat,[6] the leaves and petioles of Rheum species, and asparagus. Tartary buckwheat seeds have been found to contain more rutin (about 0.8-1.7% dry weight) than common buckwheat seeds (0.01% dry weight).[6] Rutin is also found in the fruit of the fava d'anta tree (from Brazil), fruits and flowers of the pagoda tree, fruits and fruit rinds (especially the citrus fruits orange, grapefruit, lemon, and lime) and apple; berries such as mulberry, ash tree fruits, aronia berries and cranberries.[7]

Rutin is one of the primary flavonols found in 'clingstone' peaches.[8]

Chemical relatives[edit]

Rutin (quercetin rutinoside), like quercitrin, is a glycoside of the flavonoid quercetin. As such, the chemical structures of both are very similar, with the difference existing in the hydroxyl functional group. Both quercetin and rutin are used in many countries as medications for blood vessel protection, and are ingredients of numerous multivitamin preparations and herbal remedies.

Role as ligand[edit]

It can combine with cations,[which?] supplying nutrients from the soil to the cells in plants.[citation needed] In humans, it attaches to the iron ion Fe2+, preventing it from binding to hydrogen peroxide, which would otherwise create a highly reactive free radical that may damage cells. It is also an antioxidant.

Furthermore, it has been shown to inhibit in vitro the vascular endothelial growth factor[9] in subtoxic concentrations, so acts as an inhibitor of angiogenesis. This finding may have potential relevance for the control of some cancers.

Health effects[edit]

While a body of evidence for the effects of rutin and quercetin is available in mice,[10] rats,[11] hamsters,[12] and rabbits,[13] as well as in vitro studies,[14] no clinical studies directly demonstrate significant, positive effects of rutin as dietary supplement in humans.

  • Rutin inhibits platelet aggregation,[15] as well as decreases capillary permeability, making the blood thinner and improving circulation.[citation needed]
  • Rutin shows anti-inflammatory activity in some animal and in vitro models.[16][17]
  • Rutin inhibits aldose reductase activity.[18] Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into the sugar alcohol sorbitol.
  • Recent studies show rutin could help prevent blood clots, so could be used to treat patients at risk of heart attacks and strokes.[19]
  • Some evidence also shows rutin can be used to treat hemorrhoids, varicosis, and microangiopathy.[20]
  • Rutin increases thyroid iodide uptake in rats without raising serum T3 or T4.[21]
  • Rutin is also an antioxidant;[22] compared to quercetin, acacetin, morin, hispidulin, hesperidin, and naringin, it was found to be the strongest.[23][unreliable source?] However, in other trials, the effects of rutin were lower or negligible compared to those of quercetin.[24][25]

Hydroxyethylrutosides, synthetic hydroxyethyl acetylations of rutin, are used in the treatment of chronic venous insufficiency.

In veterinary medicine[edit]

Rutin may have a veterinary use in the management of chylothorax in dogs and cats.[26]


The enzyme quercitrinase can be found in Aspergillus flavus.[27] It is an enzyme in the rutin catabolic pathway.[28]


  1. ^ Merck Index, 12th Edition, 8456
  2. ^ Krewson, C. F.; Naghski, J. (2006). "Some physical properties of rutin". Journal of the American Pharmaceutical Association 41 (11): 582–7. doi:10.1002/jps.3030411106. PMID 12999623. 
  3. ^ Lucci; Mazzafera (2009). "Rutin synthase in fava d'anta: Purification and influence of stressors". Canadian journal of plant science 89 (5): 895–902. doi:10.4141/CJPS09001. 
  4. ^ Purification and identification of active antibacterial components in Carpobrotusedulis L. Elmarie van der Watt and Johan C Pretorius, Journal of Ethnopharmacology, Volume 76, Issue 1, June 2001, Pages 87–91, doi:10.1016/S0378-8741(01)00197-0
  5. ^ Antioxidant and Antibacterial Properties of Mesembryanthemum crystallinum and Carpobrotus edulis Extracts. Bouftira Ibtissem, Chedly Abdelly and Souad Sfar, Advances in Chemical Engineering and Science, 2012, Vol. 2 No. 3, pages 359-365, doi:10.4236/aces.2012.23042
  6. ^ a b Kreft S, Knapp M, Kreft I; Knapp; Kreft (November 1999). "Extraction of rutin from buckwheat (Fagopyrum esculentum Moench) seeds and determination by capillary electrophoresis". J. Agric. Food Chem. 47 (11): 4649–52. doi:10.1021/jf990186p. PMID 10552865. 
  7. ^ Curbing Clots, Sept, 2012
  8. ^ Chang, S; Tan, C; Frankel, EN; Barrett, DM (2000). "Low-density lipoprotein antioxidant activity of phenolic compounds and polyphenol oxidase activity in selected clingstone peach cultivars". Journal of agricultural and food chemistry 48 (2): 147–51. doi:10.1021/jf9904564. PMID 10691607. 
  9. ^ Luo; et al.; King, Sarah M.; Chen, Yi Charlie (2008). "Inhibition of Cell Growth and VEGF Expression in Ovarian Cancer Cells by Flavonoids". Nutrition and Cancer 60 (6): 800–9. doi:10.1080/01635580802100851. PMID 19005980. 
  10. ^ Enkhmaa; et al.; Katsube, T; Kitajima, K; Anuurad, E; Yamasaki, M; Yamane, Y (2005). "Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice". J Nutr 135 (4): 729–34. PMID 15795425. 
  11. ^ Santos; et al.; Nagem, TJ; Pinto, AS; Oliveira, MG (1999). "HYPOLIPIDAEMIC EFFECTS OF NARINGENIN, RUTIN, NICOTINIC ACID AND THEIR ASSOCIATIONS". Pharmacological Research 40 (6): 493–6. doi:10.1006/phrs.1999.0556. PMID 10660947. 
  12. ^ Auger; et al.; Gérain, Peggy; Lequeux, Nadine; Bornet, Aurélie; Serisier, Samuel; Besançon, Pierre; Caporiccio, Bertrand et al. (2005). "Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation". J Agric Food Chem. 53 (6): 2015–21. doi:10.1021/jf048177q. PMID 15769129. 
  13. ^ Juźwiak; et al.; Mokrzycki, K; Marchlewicz, M; Białecka, M; Wenda-Rózewicka, L; Gawrońska-Szklarz, B; Droździk, M (2005). "Effect of quercetin on experimental hyperlipidemia and atherosclerosis in rabbits". Pharmacol Rep. 57 (5): 604–9. PMID 16227643. 
  14. ^ Shen; et al.; Lin, HY; Huang, HC; Ko, CH; Yang, LL; Chen, YC (2002). "In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production". European Journal of Pharmacology 446 (1–3): 187–94. doi:10.1016/S0014-2999(02)01792-2. PMID 12098601. 
  15. ^ Navarro-Núñez; et al.; Palomo, M.; Martínez, C.; Vicente, V.; Castillo, J.; Benavente-García, O.; Diaz-Ricart, M. et al. (2008). "Apigenin Inhibits Platelet Adhesion and Thrombus Formation and Synergizes with Aspirin in the Suppression of the Arachidonic Acid Pathway". J. Agric. Food Chem. 56 (9): 2970–6. doi:10.1021/jf0723209. PMID 18410117. 
  16. ^ Guardia; et al.; Juarez, AO; Pelzer, LE (2001). "Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat". Il Farmaco 56 (9): 683–7. doi:10.1016/S0014-827X(01)01111-9. PMID 11680812. 
  17. ^ Chan Hun Jung; et al.; Cho, Chul Hyung; Kim, Chang Jong (2007). "Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin". Arch. Pharmacal Research 30 (12): 1599–1607. doi:10.1007/BF02977330. 
  18. ^ G. Bhanuprakash Reddy1,*, P. Muthenna1, C. Akileshwari1, Megha Saraswat1 and J. Mark Petrash2. "Inhibition of aldose reductase and sorbitol accumulation by dietary rutin". Current Science 101 (9): 1191–1197. 
  19. ^ Reporter, Daily Mail (9 May 2012). "Chemical found in apples, onions and green tea can help beat blood clots". London: Mail Online. Retrieved 11 May 2012. 
  20. ^ http://www.naturalstandard.com/index-abstract.asp?create-abstract=/monographs/herbssupplements/patient-rutin.asp
  21. ^ http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0073908
  22. ^ Metodiewa, Diana; Kochman, Agata; Karolczak, Stefan (1997). "Evidence for antiradical and antioxidant properties of four biologically active N,N-Diethylaminoethyl ethers of flavaone oximes: A comparison with natural polyphenolic flavonoid rutin action". IUBMB Life 41 (5): 1067. doi:10.1080/15216549700202141. 
  23. ^ http://www.diet-and-health.net/Supplements/Rutin.html
  24. ^ Bando, Noriko; Muraki, Naomi; Murota, Kaeko; Terao, Junji; Yamanishi, Rintaro (2010). "Ingested quercetin but not rutin increases accumulation of hepatic β-carotene in BALB/c mice". Molecular Nutrition & Food Research 54: S261. doi:10.1002/mnfr.200900329. 
  25. ^ Chow, Jyh-Ming; Shen, Shing-Chuan; Huan, Steven K.; Lin, Hui-Yi; Chen, Yen-Chou (2005). "Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages". Biochemical Pharmacology 69 (12): 1839–51. doi:10.1016/j.bcp.2005.03.017. PMID 15876423. 
  26. ^ Kopko, S. H. (2005). "The use of rutin in a cat with idiopathic chylothorax". The Canadian veterinary journal. La revue veterinaire canadienne 46 (8): 729–731. PMC 1180424. PMID 16187718.  edit
  27. ^ quercitrinase on www.brenda-enzymes.org
  28. ^ Tranchimand, Sylvain; Brouant, Pierre; Iacazio, Gilles (2010). "The rutin catabolic pathway with special emphasis on quercetinase". Biodegradation 21 (6): 833–59. doi:10.1007/s10532-010-9359-7. PMID 20419500. 

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KESEHATAN merupakan bagian penting dari kehidupan. Karena itu, menjaga dan rutin memeriksa kondisi kesehatan sangat penting dilakukan. Dengan rutin memeriksa kesehatan, kita bisa menjaga kondisi tubuh, termasuk bila memiliki penyakit.

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VIVAnews - Menteri Tenaga Kerja dan Transmigrasi, Muhaimin Iskandar, mengaku senang dengan adanya inspeksi mendadak (sidak) oleh Komisi Pemberantasan Korupsi dan Kepolisian di terminal II Bandar Udara Internasional Soekarno-Hatta. Sidak itu ...
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Buckwheat also contains no gluten, and is therefore safe for people with gluten allergy or celiac disease; it's high in iron, zinc, selenium, manganese, magnesium copper and phosphorus; and it contains a phytochemical called rutin, which is beneficial ...
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Rutin makan yogurt bikin tekanan darah turun, (Foto: Healthmeup). BANYAK manfaat yang bisa didapat dengan mengonsumsi yogurt, selain menjaga sistem pencernaan tetap sehat. Selain itu, yogurt juga bisa membantu mengontrol tekanan darah.

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