| Reticular pigmented anomaly of the flexures | |
|---|---|
| Classification and external resources | |
| OMIM | 179850 |
Reticular pigmented anomaly of the flexures (also known as "Dark dot disease," and "Dowling–Degos' disease") is a reticular pigmented anomaly of the flexures, an autosomal-dominant pigmentary disorder appearing in adolescence or adulthood, affecting the axillae, neck, and inframammary/sternal areas.[1]:856 This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.[2]
It is associated with KRT5.[3]
See also [edit]
References [edit]
- ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ^ Betz RC, Planko L, Eigelshoven S, et al. (March 2006). "Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease". Am. J. Hum. Genet. 78 (3): 510–9. doi:10.1086/500850. PMC 1380294. PMID 16465624.
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