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Quispe Sisa (ca. 1518 – 1559) was the daughter of the Inca ruler Huayna Capac and the curaca Contarhucho. She was baptized as Inés Huaylas Yupanqui when she was given in marriage at a young age to Francisco Pizarro by her brother Atahualpa. In 1534, she gave birth to Francisca Pizarro Yupanqui and Gonzalo Pizarro the following year. During the siege of Lima, led by Manco Inca Yupanqui, Quispe Sisa sent several runners with messages to her mother in Huaylas asking for help. Her mother Contarhucho sent in On September 12, 1536 an army to help Pizarro defend Lima.

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