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Punicalagin
Chemical structure of  punicalagin
Names
Other names
2,3-(S)-hexahydroxydiphenoyl-4,6-(S,S)-gallagyl-D-glucose
α-punicalagin
β-punicalagin
Identifiers
65995-63-3 YesY
ChEMBL ChEMBL506814 N
Jmol 3D model Interactive image
PubChem 16129869
Properties
C48H28O30
Molar mass 1084.71 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water-soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]

References[edit]

  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296. 
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844. 
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326. 

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Punicalagin — Please support Wikipedia.
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179 news items

Star2.com

Star2.com
Sat, 16 Apr 2016 16:01:10 -0700

Studies on the properties of pomegranate juice in pomegranate seeds have revealed two magical components: ellagic acid, a polyphenol compound that fights damage from free radicals; and punicalagin, a “supernutrient” that promotes the body's capacity to ...

The Raw Food World News

The Raw Food World News
Sun, 24 Aug 2014 17:33:45 -0700

Recently, pomegranate is getting a lot of attention due to the research of Dr. Dr Olumayokun Olajide's findings that punicalagin, a compound found in pomegranate, could prevent or slow the progression of Alzheimer's Disease. (1). Pomegranate's are one ...

Science Daily (press release)

Science Daily (press release)
Fri, 22 Aug 2014 08:26:54 -0700

The key breakthrough by Dr Olajide and his co-researchers is to demonstrate that punicalagin, which is a polyphenol -- a form of chemical compound -- found in pomegranate fruit, can inhibit inflammation in specialised brain cells known as micrologia.

천지일보

천지일보
Sun, 01 May 2016 04:37:30 -0700

석류도 푸니칼라긴(punicalagin)을 비롯한 항산화 성분이 풍부해 꾸준히 복용하면 혈액 내 활성산소를 제거하는 역할을 할 수 있다. 콜레스테롤이 증가하면 이로 인해 동맥경화가 나타날 수 있는데 이러한 기전을 방지하는 데에 도움을 주는 것으로 알려져 있다.

Nature.com

Nature.com
Fri, 12 Feb 2016 05:00:52 -0800

The mechanism of IL-1β release was then further interrogated using the complex polyphenolic compound punicalagin (Supplementary Figure 2A). We discovered that punicalagin prevented ATP-induced IL-1β secretion, but not its processing. Therefore, after ...
 
VnExpress
Sat, 09 Apr 2016 18:07:30 -0700

Phân tích dược lý cho thấy thạch lựu bì chứa punicalin, punicalagin, acid ursolic, isorquercitrin, axit malic, granatin B. Nhiều nghiên cứu chứng minh, punicalin và punicalagin chống lạisự tăng sinh trong tế bào H9 của virus HIV và ức chế hoạt tính sao ...

Yahoo Health

Yahoo Health
Fri, 18 Dec 2015 12:12:24 -0800

Research published in the journal Molecular Nutrition & Food Research in 2014 determined that punicalagin, another compound found in pomegranates, may help slow the progression of Alzheimer's by treating brain inflammation. While the latest finding is ...
 
MyAJC
Thu, 24 Mar 2016 21:30:00 -0700

One polyphenol -- punicalagin -- is unique to pomegranates. During digestion, our body produces urolithins from punicalagin and related polyphenols. In laboratory studies, these urolithins have decreased prostate cancer cell growth and its ability to ...
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