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Punicalagin
Chemical structure of  punicalagin
Names
Other names
2,3-(S)-hexahydroxydiphenoyl-4,6-(S,S)-gallagyl-D-glucose
α-punicalagin
β-punicalagin
Identifiers
CAS number 65995-63-3 YesY
ChEMBL ChEMBL506814 N
Jmol-3D images Image
PubChem 16129869
Properties
C48H28O30
Molar mass 1084.71 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]

References[edit]

  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296.  edit
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844.  edit
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326.  edit

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Punicalagin — Please support Wikipedia.
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117 news items

The Raw Food World News

The Raw Food World News
Sun, 24 Aug 2014 17:33:45 -0700

(TRFW News) Recently, pomegranate is getting a lot of attention due to the research of Dr. Dr Olumayokun Olajide's findings that punicalagin, a compound found in pomegranate, could prevent or slow the progression of Alzheimer's Disease. (1).
 
The Guardian
Thu, 26 Feb 2015 03:07:58 -0800

The leaves of Terminalia catappa contain many hydrolysable tannins, such as punicalagin, punicalin, terflavins, A and B tergallagin, tercatain, chebulagic acid, geraniin, granatin B, and corilagin, but no caffeine. The leaves are combined with other ...

ثمار برس

ثمار برس
Sat, 28 Feb 2015 23:52:30 -0800

الطازج أو المجفف وقشور ثمرة الرمان التي تحتوي علي مواد عفصية (Tannins) بنسبة 20 25% وهو عبارة عن Gall tannins والذي يشمل Granatine, Punicalagin, Punicalin.وقد وجد أن استخدام مسحوق قشر الثمرة إذا مزجت مع العسل النقي يعطي نتائج ايجابية ضد قرحة المعدة ويجب ...

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Yahoo!7 News

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Fri, 29 Aug 2014 00:22:52 -0700

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Mon, 15 Dec 2014 10:10:56 -0800

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