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Punicalagin
Chemical structure of  punicalagin
Names
Other names
2,3-(S)-hexahydroxydiphenoyl-4,6-(S,S)-gallagyl-D-glucose
α-punicalagin
β-punicalagin
Identifiers
65995-63-3 YesY
ChEMBL ChEMBL506814 N
Jmol-3D images Image
PubChem 16129869
Properties
C48H28O30
Molar mass 1084.71 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]

References[edit]

  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296.  edit
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844.  edit
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326.  edit

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Punicalagin — Please support Wikipedia.
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116 news items

 
Big News Network.com
Thu, 21 May 2015 05:22:30 -0700

As per Singh, pomegranates are a rich source of dietary fibre and an anti-oxidant called punicalagin, which helps reduce free radical damage and hence slows down the ageing process. She continued that red wine is rich in resavertrol, which works as a ...

The Raw Food World News

The Raw Food World News
Sun, 24 Aug 2014 17:33:45 -0700

(TRFW News) Recently, pomegranate is getting a lot of attention due to the research of Dr. Dr Olumayokun Olajide's findings that punicalagin, a compound found in pomegranate, could prevent or slow the progression of Alzheimer's Disease. (1).

Care2.com

Care2.com
Sat, 02 May 2015 14:04:45 -0700

They are so powerful that pomegranate juice has been found to have three times the antioxidant activity of red wine and green tea (3). Pomegranate extract and powder is typically made from the peel, due to its high antioxidant and punicalagin content.

The Epoch Times

The Epoch Times
Tue, 05 May 2015 12:22:43 -0700

They are so powerful that pomegranate juice has been found to have three times the antioxidant activity of red wine and green tea. Pomegranate extract and powder is typically made from the peel, due to its high antioxidant and punicalagin content.

Daily Mail

Catholic Online
Fri, 29 Aug 2014 10:23:22 -0700

LOS ANGELES, CA (Catholic Online) - The chemical punicalagin, a form of a chemical compound known as polyphenol, helps prevent the inflammation that destroys brain cells known as micrologia, and scientists hope that these findings may also potentially ...

Alzheimer's News Today

Alzheimer's News Today
Mon, 01 Sep 2014 08:34:29 -0700

Punicalagin, the polyphenol chemical compound found in pomegranate, is able to block the inflammation of certain cells of the brain, the micrologia, which are responsible for the deterioration of more brain cells, causing the worsening of Alzheimer's, ...
 
Canon City Daily Record
Tue, 24 Mar 2015 16:15:00 -0700

A compound found only in pomegranates called punicalagin has been shown to benefit the heart and blood vessels. Punicalagin is the major component responsible for pomegranates antioxidant and health benefits. It not only lowers cholesterol, but also ...
 
Science 2.0 (blog)
Wed, 18 Mar 2015 13:36:22 -0700

Reverse aging drugs discovered. (March 2015). "A new class of anti-aging drugs has been identified in a study by a team from The Scripps Research Institute and the Mayo Clinic. In mice, the drugs reduce frailty, improve heart function and extends a ...
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