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Chemical structure of  punicalagin
CAS number 65995-63-3 YesY
PubChem 16129869
Jmol-3D images Image 1
Molecular formula C48H28O30
Molar mass 1084.71 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]


  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296.  edit
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844.  edit
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326.  edit

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Punicalagin — Please support Wikipedia.
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109 news items

Channel 2 News
Wed, 19 Nov 2014 08:41:15 -0800

Among the strongest anti-oxidant is punicalagin, a strong polyphenol (protectant) unique to pomegranates and anthocyanin which produces the deep rich pomegranate color. The secret to remove the seeds (arils) is to not remove them under water. Cut the ...

The Raw Food World News

The Raw Food World News
Sun, 24 Aug 2014 17:33:45 -0700

(TRFW News) Recently, pomegranate is getting a lot of attention due to the research of Dr. Dr Olumayokun Olajide's findings that punicalagin, a compound found in pomegranate, could prevent or slow the progression of Alzheimer's Disease. (1).
Nutritional Outlook
Tue, 11 Nov 2014 11:41:15 -0800

They then compared the extract to some of its key phenolic compounds—punicalagin, ellagic acid, and gallic acid—as well as an AGE-lowering drug called aminoguanidine. Compared to the drug, pomegranate extract and its isolated constituents were all ...

Daily Times

Daily Times
Wed, 19 Nov 2014 00:37:30 -0800

It said that a compound found only in pomegranates called punicalagin is shown to benefit the heart and blood vessels, it not only lowers cholesterol, but also lowers blood pressure and increases the speed at which heart blockages – atherosclerosis ...
Centre Daily Times
Fri, 24 Oct 2014 23:11:15 -0700

This ancient fruit recently made its way back into the news because of a compound found only in pomegranates, called punicalagin, has shown to benefit the heart and blood vessels. Punicalagin is the major component responsible for pomegranate's ...
Natural Products INSIDER
Fri, 07 Nov 2014 10:02:38 -0800

In the study, researchers investigated the in vitro anti-glycation effects of the pomegranate fruit extract (PE), its phenolic constituents [punicalagin (PA), ellagic acid (EA) and gallic acid (GA)], and their in vivo derived colonic metabolites ...

Nutritional Outlook

Nutritional Outlook
Mon, 03 Nov 2014 10:56:15 -0800

In the case of pomegranate juice, researchers argue that larger trials are needed, perhaps on higher juice doses. Pomegranates contain a number of compounds that may have hypoglycemic potential. These include punicic acid, punicalagin, ellagic acid, ...
Wed, 19 Nov 2014 04:00:00 -0800

U.K. researchers believe that a chemical compound within pomegranates called punicalagin may have characteristics that enable it to slow the progress of dementia and Parkinson's disease. Punicalagin prevents the swelling of microglia, specialized brain ...

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