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Chemical structure of  punicalagin
CAS number 65995-63-3 YesY
PubChem 16129869
Jmol-3D images Image 1
Molecular formula C48H28O30
Molar mass 1084.71 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]


  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296.  edit
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844.  edit
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326.  edit

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31 news items

The Epoch Times

The Epoch Times
Fri, 17 Oct 2014 05:56:15 -0700

A compound found only in pomegranates called punicalagin is shown to benefit the heart and blood vessels. Punicalagin is the major component responsible for pomegranate's antioxidant and health benefits. It not only lowers cholesterol, but also lowers ...

Doctor Tipster

Doctor Tipster
Fri, 26 Sep 2014 09:31:07 -0700

His research claims that punicalagin, a polypheno, which is a form of chemical compound found in pomegranates, can inhibit inflammation in special brain cells called micro logia. Dr. Olajide worked with a team of specialists, his co-researchers ...

The Epoch Times

The Epoch Times
Sun, 19 Oct 2014 11:56:15 -0700

Pomegranate contains a unique and powerful antioxidant called punicalagin, the most abundant antioxidant in pomegranate, responsible for more than half of the antioxidant activity of pomegranate juice. Pomegranate juice has been analyzed to have ...

Hindustan Times

Hindustan Times
Thu, 25 Sep 2014 05:56:59 -0700

A recent study by the researchers from the University of Huddersfield, UK, suggests that pomegranate has a miracle antioxidant compound, punicalagin, which can prevent Alzheimer's, and can also slow down its onset and progression. Make the most of it: ...
Food Consumer
Sat, 20 Sep 2014 12:07:30 -0700

The current study tested in vitro pomegranate fruit extract (PE), its phenolic constituents (punicalagin (PA), ellagic acid (EA) and gallic acid (GA) and in vivo metabolites like urolithin A (UA) and urolithin B (UB). Pomegranate fruit are known to ...

The Epoch Times

The Epoch Times
Wed, 08 Oct 2014 07:35:42 -0700

Finally, pomegranate extract rich in punicalagin has been found reduce the adverse effects of perturbed stress on arterial segments exposed to disturbed flow. Anti-Infective: Plaque buildup in the arteries often involves secondary viral and bacterial ...
Ce se intampla doctore:
Tue, 21 Oct 2014 14:11:15 -0700

Rodiile ar putea stopa evoluţia maladiei Alzheimer prin intermediul unui ingredient care previne inflamarea celulelor cerebrale, se afirmă într-un studiu realizat recent de Universitatea Huddersfield din Marea Britanie. Ingredientul, denumit ...

المدينة نيوز

المدينة نيوز
Sat, 18 Oct 2014 03:18:45 -0700

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