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Punicalagin
Chemical structure of  punicalagin
Identifiers
CAS number 65995-63-3 YesY
PubChem 16129869
ChEMBL CHEMBL506814 N
Jmol-3D images Image 1
Properties
Molecular formula C48H28O30
Molar mass 1084.71 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]

References[edit]

  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296.  edit
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844.  edit
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326.  edit

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Punicalagin — Please support Wikipedia.
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106 news items

Memphis Commercial Appeal

Memphis Commercial Appeal
Mon, 15 Dec 2014 10:00:00 -0800

One of these is punicalagin, which has been shown to lower both cholesterol and blood pressure. In one study, heart patients who already had carotid artery blockages were given an ounce of pomegranate juice every day for a year, resulting in a 12 ...

The Raw Food World News

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Sun, 24 Aug 2014 17:33:45 -0700

(TRFW News) Recently, pomegranate is getting a lot of attention due to the research of Dr. Dr Olumayokun Olajide's findings that punicalagin, a compound found in pomegranate, could prevent or slow the progression of Alzheimer's Disease. (1).
 
Channel 2 News
Wed, 19 Nov 2014 08:41:15 -0800

Among the strongest anti-oxidant is punicalagin, a strong polyphenol (protectant) unique to pomegranates and anthocyanin which produces the deep rich pomegranate color. The secret to remove the seeds (arils) is to not remove them under water. Cut the ...
 
LifeHacker India
Wed, 26 Nov 2014 05:41:15 -0800

It has a component called punicalagin, which lowers your blood pressure. 3. Liver: Pomegranate extract doesn't only protect the liver, it even regenerates it after it has been damaged because of your drinking problems. 4. Aging: The antioxidants ...

Daily Times

Daily Times
Wed, 19 Nov 2014 00:43:07 -0800

It said that a compound found only in pomegranates called punicalagin is shown to benefit the heart and blood vessels, it not only lowers cholesterol, but also lowers blood pressure and increases the speed at which heart blockages – atherosclerosis ...
 
DigitalJournal.com
Wed, 19 Nov 2014 04:00:00 -0800

U.K. researchers believe that a chemical compound within pomegranates called punicalagin may have characteristics that enable it to slow the progress of dementia and Parkinson's disease. Punicalagin prevents the swelling of microglia, specialized brain ...

Daily Mail

Catholic Online
Fri, 29 Aug 2014 10:23:22 -0700

LOS ANGELES, CA (Catholic Online) - The chemical punicalagin, a form of a chemical compound known as polyphenol, helps prevent the inflammation that destroys brain cells known as micrologia, and scientists hope that these findings may also potentially ...

Việt Times Australia

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