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Punicalagin
Chemical structure of  punicalagin
Names
Other names
2,3-(S)-hexahydroxydiphenoyl-4,6-(S,S)-gallagyl-D-glucose
α-punicalagin
β-punicalagin
Identifiers
65995-63-3 YesY
ChEMBL ChEMBL506814 N
Jmol-3D images Image
PubChem 16129869
Properties
C48H28O30
Molar mass 1084.71 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water-soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]

References[edit]

  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296. 
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844. 
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326. 

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Punicalagin — Please support Wikipedia.
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105 news items

Green Area

Green Area
Tue, 25 Aug 2015 05:56:15 -0700

اما قشور الجذور والسيقان فتحتوي على مواد عفصية من 20 إلى 25 بالمئة، وأهم مركبات هذه المجموعة مركب كازورين (Casuarin) وبونيكالاجين (Punicalagin) وبونيكا كورثين (Punicacortein)، كما تحتوي القشور قلويدات ببييريدنيه بنسبة 4 بالمئة في قشرة الساق، و0.8 بالمئة ...

Science 2.0

Science 2.0
Sat, 23 Aug 2014 07:31:50 -0700

The punicalagin polyphenol can inhibit inflammation in specialized brain cells known as micrologia, according to the results. This inflammation leads to the destruction of more and more brain cells, making the condition of Alzheimer's sufferers ...

Alzheimer's News Today

Alzheimer's News Today
Mon, 01 Sep 2014 08:34:29 -0700

Punicalagin, the polyphenol chemical compound found in pomegranate, is able to block the inflammation of certain cells of the brain, the micrologia, which are responsible for the deterioration of more brain cells, causing the worsening of Alzheimer's, ...

Zing News

Zing News
Tue, 11 Aug 2015 01:51:19 -0700

Quả lựu chứa punicalagin - một chất chống oxy hóa có tác dụng làm sạch đường tiêu hóa và ức chế sự phát triển của ung thư ruột kết. 9. Húng tây. 9 thực phẩm có tác dụng detox cả cơ thể cho các chị em. Không chỉ là một loại thảo dược thơm ngon, húng tây ...

Daily Mail

Catholic Online
Fri, 29 Aug 2014 10:23:22 -0700

LOS ANGELES, CA (Catholic Online) - The chemical punicalagin, a form of a chemical compound known as polyphenol, helps prevent the inflammation that destroys brain cells known as micrologia, and scientists hope that these findings may also potentially ...

Medical Daily

Medical Daily
Fri, 26 Jun 2015 04:03:10 -0700

A specific polyphenol called punicalagin is believed to be the source of pomegranate's anti-inflammatory properties. An animal study showed mice fed pomegranate juice experienced lower levels of amyloid plaque — the plaque that accumulates between the ...

najdi.si

najdi.si
Sun, 16 Aug 2015 23:33:45 -0700

Sestavini punicalagin in punicalin, ki ju vsebuje granatno jabolko, imata skoraj čudežno zdravilno delovanje – med drugim sta koristni za srce in ožilje, znižujeta slab holesterol, trigliceride in krvni tlak ter prispevata k raztapljanju oblog v žilah, ki so razlog za ...

Care2.com

Care2.com
Sat, 02 May 2015 14:04:45 -0700

They are so powerful that pomegranate juice has been found to have three times the antioxidant activity of red wine and green tea (3). Pomegranate extract and powder is typically made from the peel, due to its high antioxidant and punicalagin content.
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