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Punicalagin
Chemical structure of  punicalagin
Identifiers
CAS number 65995-63-3 YesY
PubChem 16129869
ChEMBL CHEMBL506814 N
Jmol-3D images Image 1
Properties
Molecular formula C48H28O30
Molar mass 1084.71 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]

References[edit]

  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296.  edit
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844.  edit
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326.  edit

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Punicalagin — Please support Wikipedia.
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537 news items

The Raw Food World News

Science 2.0
Sat, 23 Aug 2014 07:31:50 -0700

The punicalagin polyphenol can inhibit inflammation in specialized brain cells known as micrologia, according to the results. This inflammation leads to the destruction of more and more brain cells, making the condition of Alzheimer's sufferers ...

Daily Mail

Catholic Online
Fri, 29 Aug 2014 10:15:00 -0700

LOS ANGELES, CA (Catholic Online) - The chemical punicalagin, a form of a chemical compound known as polyphenol, helps prevent the inflammation that destroys brain cells known as micrologia, and scientists hope that these findings may also potentially ...
 
Leesville Daily Leader
Thu, 28 Aug 2014 23:11:15 -0700

The study, published in the journal Molecular Nutrition & Food Research, shows that the compound punicalagin may inhibit inflammation in the brain, which could serve as a way of slowing the progression of the diseases. New Research. Middle-aged people ...

Huddersfield Examiner

Huddersfield Examiner
Wed, 27 Aug 2014 08:03:29 -0700

The key breakthrough by Dr Olajide and his co-researchers is to demonstrate that punicalagin – which is a polyphenol, a form of chemical compound, found in pomegranate fruit – can inhibit inflammation in specialised brain cells known as micrologia.

Telegraph.co.uk

Telegraph.co.uk
Thu, 28 Aug 2014 10:03:45 -0700

This inflammation leads to the destruction of more and more brain cells, making the condition of Alzheimer's sufferers progressively worse. The team is hopeful that a drug derived from punicalagin that could treat neuro-inflammation and slow the disease.

Daily Mail

Daily Mail
Thu, 28 Aug 2014 03:30:00 -0700

University of Huddersfield researchers found that punicalagin - a chemical compound found in the pomegranate fruit - can inhibit inflammation in specialised brain cells known as micrologia. (It is inflammation that leads to Alzheimer's disease getting ...
 
soFeminine.co.uk
Wed, 13 Aug 2014 02:33:16 -0700

Clinical Beautician and founder of Pause Hydra Creme, Jane Artheton says, "Punicalagin, the major antioxidant polyphenol ingredient in pomegranate juice, is found nowhere else in nature and is thought to lower bad cholesterol and prevent it from ...

PUTEREA

Ziare.com
Sat, 30 Aug 2014 01:30:44 -0700

O substanta continuta de rodii previne inflamarea celulelor cerebrale, ceea ce ajuta la stoparea bolii Alzheimer, au descoperit recent cercetatorii britanici. Substanta cu efect benefic se numeste punicalagin si ar fi de ajutor si in cazul persoanelor ...
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