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Chemical structure of  punicalagin
Other names
65995-63-3 YesY
Jmol interactive 3D Image
PubChem 16129869
Molar mass 1084.71 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Punicalagin is an ellagitannin, a type of phenolic compounds. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, is a plant species found in South Africa.[2] These three genera are all Myrtales and the last two are both Combretaceae.

Health effects[edit]

Punicalagins are the largest molecule found intact in rat plasma after oral ingestion[3] and were found to show no toxic effects in rats who were given a 6% diet of punicalagins for 37 days.[4] Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant activity.[5]

Punicalagin is water-soluble and has high bioavailability. They are known to hydrolyze into smaller phenolic compounds such as ellagic acid in vivo where one potential mechanism is hydrolysis across the mitochondrial membrane of cultured human colon cells.[6][7]

It is a highly active carbonic anhydrase inhibitor.[8]


  1. ^ Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram, F. A.; Shalaby, N. M.; Ahmed, A. A. (2002). "Pharmacologically Active Ellagitannins from Terminalia myriocarpa". Planta Medica 68 (6): 523–527. doi:10.1055/s-2002-32549. PMID 12094296. 
  2. ^ Asres, K.; Bucar, F.; Knauder, E.; Yardley, V.; Kendrick, H.; Croft, S. L. (2001). "In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle". Phytotherapy Research 15 (7): 613–617. doi:10.1002/ptr.897. PMID 11746844. 
  3. ^ Cerda et al. Eur J Nutr. 2003 Jan;42(1), pp. 18-28
  4. ^ Cerda et al. J. Agric. Food Chem. 2003, 51, pp. 3493-3501
  5. ^ Gil et al. J Agric Food Chem 2000 48 (10), pp. 4581-4589
  6. ^ Seeram et al. Clin Chim Acta. 2004 Oct;348(1-2), pp. 63-68
  7. ^ Larrosa et al. J Nutr Biochem. 2006 Sep;17(9), pp. 611-625
  8. ^ Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin 16 (8): 787–790. doi:10.1248/bpb.16.787. PMID 8220326. 

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113 news items

The Hindu

The Hindu
Sat, 14 Nov 2015 03:03:45 -0800

In addition, the powerful anti-oxidant, punicalagin, in pomegranate juice helps prevent blood platelet clots, thereby reducing the risks of coronary heart diseases. Preparation time: 5 minutes. Total time (including brewing and cooling time): 15 minutes.

The Raw Food World News

The Raw Food World News
Sun, 24 Aug 2014 17:33:45 -0700

Recently, pomegranate is getting a lot of attention due to the research of Dr. Dr Olumayokun Olajide's findings that punicalagin, a compound found in pomegranate, could prevent or slow the progression of Alzheimer's Disease. (1). Pomegranate's are one ...
Thu, 15 Oct 2015 13:15:00 -0700

Unique to the fruit is a component called punicalagin, which is beneficial to heart and blood health, according to Fuhrman. The compound has shown to decrease blood pressure as well as increase the rate at which the body removes atherosclerosis, or ...

Daily Mail

Daily Mail
Tue, 29 Sep 2015 02:48:07 -0700

Ever wondered how to achieve the glowing skin you've always dreamed of? These eight superfoods could be the answer. Packed full of vitamins and minerals, they help repair and hydrate skin while promoting both collagen production and cross linking.

Hürriyet Aile

Hürriyet Aile
Thu, 05 Nov 2015 23:30:00 -0800

Tekli doymamış yağ asitleri içeriği açısından kalp hastalıklarına ve kansere karşı koruyucu etkilerinden dolayı zeytinyağı, punicalagin içeriği ile damar sertliğini önlemesi ve prostat kanserine karşı koruyucu etkilerinden dolayı nar, kateşin gibi ...

Medical Daily

Medical Daily
Fri, 26 Jun 2015 04:03:10 -0700

A specific polyphenol called punicalagin is believed to be the source of pomegranate's anti-inflammatory properties. An animal study showed mice fed pomegranate juice experienced lower levels of amyloid plaque — the plaque that accumulates between the ...


Sat, 02 May 2015 14:04:45 -0700

They are so powerful that pomegranate juice has been found to have three times the antioxidant activity of red wine and green tea (3). Pomegranate extract and powder is typically made from the peel, due to its high antioxidant and punicalagin content.


Mon, 07 Sep 2015 02:45:12 -0700

5 Health Benefits of Pomegranate & How to Cook with it It's not just its ruby red colour or the crystal-like seeds that makes pomegranate special. It's also the tarty and sweet taste that you experience all at once. Also referred to as the 'fruit of ...

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