Learn and talk about PLRG1, Human proteins

Pleiotropic regulator 1

Identifiers

PLRG1; Cwc1; PRL1; PRP46; PRPF46; TANGO4

External IDs

OMIM: 605961 MGI: 1858197 HomoloGene: 2004 GeneCards: PLRG1 Gene

Gene Ontology
Molecular function	• transcription corepressor activity • signal transducer activity • protein binding
Cellular component	• nucleus • nuclear speck • catalytic step 2 spliceosome
Biological process	• mRNA splicing, via spliceosome • signal transduction
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
155.46 – 155.47 Mb

Chr 3:
83.06 – 83.07 Mb

PubMed search

[1]

[2]

Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene.^[1]

Interactions [edit]

PLRG1 has been shown to interact with CDC5L.^[2]^[3]^[4]^[5]

References [edit]

^ "Entrez Gene: PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)".
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Ajuh, Paul; Lamond Angus I (November 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. (England) 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.
^ Ajuh, P; Sleeman J, Chusainow J, Lamond A I (November 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. (United States) 276 (45): 42370–81. doi:10.1074/jbc.M105453200. ISSN 0021-9258. PMID 11544257.
^ Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading [edit]

Németh K, Salchert K, Putnoky P et al. (1998). "Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis". Genes Dev. 12 (19): 3059–73. doi:10.1101/gad.12.19.3059. PMC 317193. PMID 9765207.
Ajuh P, Kuster B, Panov K et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Ajuh P, Sleeman J, Chusainow J, Lamond AI (2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. PMID 11544257.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ajuh P, Lamond AI (2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

v t e Post-transcriptional modification

Nuclear	Precursor mRNA 5′ cap formation Polyadenylation CPSF CstF PAP PAB2 CFI CFII Poly(A)-binding protein RNA splicing: intron/exon snRNP spliceosome minor spliceosome U1 alternative splicing pre-mRNA processing factor PLRG1 PRPF3 PRPF4 PRPF4B PRPF6 PRPF8 PRPF18 PRPF19 PRPF31 PRPF38A PRPF38B PRPF39 PRPF40A PRPF40B RNA editing Polyuridylation

Cytosolic	5′ cap methylation Messenger RNA decapping: DCP1A DCP1B DCP2 DCPS EDC3 EDC4

see also: disorders of transcription and post transcriptional modification, Transcription B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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PLRG1

Interactions [edit]

References [edit]

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