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Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question. Other methods of ingestion such as smoking or injection can take as little as seconds to minutes to take effect. The determination of the onset of action, however, is not completely dependent upon route of administration. There are several other factors that determine the onset of action for a specific drug, including drug formulation, dosage, and the patient receiving the drug.

Effect of Administration Route on the Onset of Action[edit]

A drug's pharmacological effects can only occur once it has been fully solubilized and has entered the blood stream. For most drugs administered orally, the drug must be ingested, pass through the stomach, and into the small intestine, where the drug molecules enter the blood stream through the villi and microvilli.[1] Gastric emptying time can vary from 0 to 3 hours,[2] and therefore plays a major role in onset of action for orally administered drugs. For intravenous administration, the pathway is much shorter because the drug is administered (usually already in solution) directly to the bloodstream.

References[edit]

  1. ^ Pang, K. Sandy (2003). "MODELING OF INTESTINAL DRUG ABSORPTION: ROLES OF TRANSPORTERS AND METABOLIC ENZYMES (FOR THE GILLETTE REVIEW SERIES)". 
  2. ^ Bummer, Paul (2012). Gastro Intestinal Tract and Oral Drug Absorption. University of Kentucky. 



Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Onset_of_action — Please support Wikipedia.
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701 news items

 
Medgadget.com (blog)
Fri, 03 Jul 2015 05:56:15 -0700

Injectable drug delivery has also proved beneficial in many cases such as unconsciousness, emergency conditions and nausea, due to rapid onset of action. The basic requirement for injectable drug delivery is that it should be pyrogen free, sterile and ...
 
wsnewspublishers
Fri, 03 Jul 2015 02:22:30 -0700

KENGREAL is the first and only intravenous, reversible P2Y12 platelet inhibitor with an immediate onset of action for patients undergoing PCI that, in clinical trials, has been shown to reduce the risk of periprocedural thrombotic events, counting ...
 
MarketWatch
Tue, 23 Jun 2015 14:45:00 -0700

Moreover, some diseases require rapid onset of action. This is possible through injections; some patients, though, find it inconvenient and painful to administer injections. Oral thin films provide the best alternative dosage form for administering ...

Bidness ETC

MarketWatch
Mon, 22 Jun 2015 12:03:27 -0700

KENGREAL is the first and only intravenous, reversible P2Y12 platelet inhibitor with an immediate onset of action for patients undergoing PCI that, in clinical trials, has been shown to reduce the risk of periprocedural thrombotic events, including ...

Pulse Headlines

Pulse Headlines
Mon, 29 Jun 2015 04:13:30 -0700

As per information released by Novartis, secukinumab exhibited the quick onset of action and was appreciably better to placebo in removing the signs and symptoms of psoriatic arthritis or PsA. The results and efficacy sustained for more than a year.
 
The Verge
Wed, 17 Jun 2015 10:15:00 -0700

A single-dose treatment against malaria worked in mice to cure them of the disease. The drug also worked to block infection in healthy mice and to stop transmission, according to a study published in Nature today. The fact that the drug can act against ...
 
Inquirer.net
Fri, 03 Jul 2015 08:56:15 -0700

A minimum period of four to 12 weeks is recommended with a daily dosage of two soft gel capsules each day for Arthrite's onset of action to reach its peak level of providing relief. One of the key aspects of Arthrite polyherbal formulation is its ...

MedPage Today

MedPage Today
Tue, 16 Jun 2015 12:01:26 -0700

In performing the study, patients first completed a 7-day baseline period in which they recorded their daily first morning time to onset of action following their regularly scheduled morning dose of levodopa. At the end of the baseline period, patients ...
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