digplanet beta 1: Athena
Share digplanet:

Agriculture

Applied sciences

Arts

Belief

Business

Chronology

Culture

Education

Environment

Geography

Health

History

Humanities

Language

Law

Life

Mathematics

Nature

People

Politics

Science

Society

Technology

Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question. Other methods of ingestion such as smoking or injection can take as little as seconds to minutes to take effect. The determination of the onset of action, however, is not completely dependent upon route of administration. There are several other factors that determine the onset of action for a specific drug, including drug formulation, dosage, and the patient receiving the drug.

Effect of Administration Route on the Onset of Action[edit]

A drug's pharmacological effects can only occur once it has been fully solubilized and has entered the blood stream. For most drugs administered orally, the drug must be ingested, pass through the stomach, and into the small intestine, where the drug molecules enter the blood stream through the villi and microvilli.[1] Gastric emptying time can vary from 0 to 3 hours,[2] and therefore plays a major role in onset of action for orally administered drugs. For intravenous administration, the pathway is much shorter because the drug is administered (usually already in solution) directly to the bloodstream.

References[edit]

  1. ^ Pang, K. Sandy (2003). "MODELING OF INTESTINAL DRUG ABSORPTION: ROLES OF TRANSPORTERS AND METABOLIC ENZYMES (FOR THE GILLETTE REVIEW SERIES)". 
  2. ^ Bummer, Paul (2012). Gastro Intestinal Tract and Oral Drug Absorption. University of Kentucky. 



Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Onset_of_action — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.
69241 videos foundNext > 

Medication Onset of Action & Peak Effect

Medication Onset of Action & Peak Effect By Jason Ortiz & Eli Pumpian Pharmacology 3182.

The Increasing Incidence of Young Onset Colorectal Cancer A Call to Action

Dr. Whitney Jones from the University of Kentucky in Louisville, and Jasmine Greenamyer from the Colon Cancer Alliance in Washington, DC, discuss the article...

Inca Onset Performance Breakthrough

The Inca Onset represents a breakthrough in flatbed inkjet technology, and has forever changed the way in which display graphics are produced.

Pronounce Medical Words ― Onset Of Action

This video shows you how to say Onset Of Action. How would you pronounce Onset Of Action?

INCA Digital Onset Printer in Action at Tempt In-Store Productions

The most impressive flatbed Inca has introduced to date, the Onset is capable of delivering a print throughput up to 600sq.m/hr (6458sq.ft/hr), equivalent to...

How to Say or Pronounce Onset Of Action

Get those medical secrets: http://www.health101.pw/Medical-Secrets.shtml This video shows you how to say or pronounce Onset Of Action. Audio is from cancer.gov.

Middle Earth: Shadow Of Mordor - Stealth, Action and Random Onset Cowardice

Running on a GTX 660 with 2GB of vram, 8Gb ram, an 8-core 3.8 (overclocked) amd processor.

Onset Uzi action

Freeze the Action! - ON SET ep. 15

www.adorama.com Join us ONSET as we demonstrate action stopping flash duration while capturing a choreographed fight scene created especially for AdoramaPro ...

Celebrity Onset and AA Action Towing

Celebrity Onset is a one hour show featuring a diverse mixture of celebrity interviews, audience participation, and contests. Celebrity Onset will extend out...

69241 videos foundNext > 

719 news items

 
Lexology (registration)
Wed, 14 Jan 2015 13:56:15 -0800

The National Advertising Division (NAD) recently recommended that Novartis Consumer Health, Inc. discontinue advertising that its Theraflu product “starts to get to work in your body in 5 minutes.” NAD concluded that the claim communicates that ...
 
CNNMoney
Thu, 29 Jan 2015 04:00:00 -0800

"The positive clinical study results, now part of the European label, demonstrate SPEDRA's rapid onset of action, a key point of differentiation in the ED market. We believe this enhances the therapeutic options for men suffering from ED and for the ...

Seeking Alpha (registration)

Seeking Alpha (registration)
Wed, 28 Jan 2015 06:48:23 -0800

Though several months behind its competitor, ZS Pharma's ZS-9 has similar efficacy in outpatient maintenance of normokalemia while boasting a favorable, more rapid onset of action. The faster onset of action suggests additional application in the acute ...

Equities.com

Equities.com
Wed, 28 Jan 2015 15:37:30 -0800

Physician benefits may include increased control of patient compliance, rapid onset of action, and increased office efficiency. The EyeGate® II Delivery System has the potential to offer a non-invasive method of drug delivery as an alternative to the ...
 
Business Wire (press release)
Wed, 28 Jan 2015 02:30:00 -0800

These films can be administered through sublingual, buccal or oral mucosal route, providing advantage of rapid onset of action. - A number of these products (approx. 38%) are based on either MonoSol's PharmFilm technology or Applied Pharma Research ...

Science World Report

Monthly Prescribing Reference
Thu, 18 Sep 2014 06:41:15 -0700

Vivus and Auxilium announced that the Food and Drug Administration (FDA) has approved a supplemental new drug application (sNDA) for Stendra (avanafil) to be taken ~15 minutes before sexual activity in the treatment of erectile dysfunction. Stendra ...
 
Healio
Tue, 27 Jan 2015 12:34:24 -0800

Use of morphine delayed the onset of action of antiplatelet agents in patients with STEMI who were undergoing PCI, researchers reported. Featured. TCT · ESC · SCAI · Highlights from AHA Scientific Sessions · Highlights from Cardiometabolic Health ...
 
Nasdaq
Mon, 05 Jan 2015 05:14:35 -0800

The compound has been evaluated in CKD patients with hyperkalemia, including a two part Phase 3 study, a 12-month Phase 2 trial and a 48-hour Phase 1 onset-of-action study. In all of those studies, Patiromer FOS met its efficacy endpoints and the ...
Loading

Oops, we seem to be having trouble contacting Twitter

Support Wikipedia

A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia. Please add your support for Wikipedia!

Searchlight Group

Digplanet also receives support from Searchlight Group. Visit Searchlight