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Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question. Other methods of ingestion such as smoking or injection can take as little as seconds to minutes to take effect. The determination of the onset of action, however, is not completely dependent upon route of administration. There are several other factors that determine the onset of action for a specific drug, including drug formulation, dosage, and the patient receiving the drug.

Effect of Administration Route on the Onset of Action[edit]

A drug's pharmacological effects can only occur once it has been fully solubilized and has entered the blood stream. For most drugs administered orally, the drug must be ingested, pass through the stomach, and into the small intestine, where the drug molecules enter the blood stream through the villi and microvilli.[1] Gastric emptying time can vary from 0 to 3 hours,[2] and therefore plays a major role in onset of action for orally administered drugs. For intravenous administration, the pathway is much shorter because the drug is administered (usually already in solution) directly to the bloodstream.

References[edit]

  1. ^ Pang, K. Sandy (2003). "MODELING OF INTESTINAL DRUG ABSORPTION: ROLES OF TRANSPORTERS AND METABOLIC ENZYMES (FOR THE GILLETTE REVIEW SERIES)". 
  2. ^ Bummer, Paul (2012). Gastro Intestinal Tract and Oral Drug Absorption. University of Kentucky. 



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Portman's data shows that paroxetine does indeed work to treat hot flashes, and the onset of action is certainly quick. It is faster than the effect of these drugs in treating depression. Typically you don't see an anti-depressant effect until at least ...
 
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About one-third of people suffering from depression do not get relief from first-line antidepressant medications. Of significant concern is the fact that even when effective there is a delay in onset of action of two weeks or more, during which time ...
 
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Stendra has the most rapid onset of action. Since planning and timing of sexual encounters is not predictable for many, there is a very good reason to speculate that Stendra will provide a better patient experience. Therefore, Stendra may well be the ...
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