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Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question. Other methods of ingestion such as smoking or injection can take as little as seconds to minutes to take effect. The determination of the onset of action, however, is not completely dependent upon route of administration. There are several other factors that determine the onset of action for a specific drug, including drug formulation, dosage, and the patient receiving the drug.

Effect of Administration Route on the Onset of Action[edit]

A drug's pharmacological effects can only occur once it has been fully solubilized and has entered the blood stream. For most drugs administered orally, the drug must be ingested, pass through the stomach, and into the small intestine, where the drug molecules enter the blood stream through the villi and microvilli.[1] Gastric emptying time can vary from 0 to 3 hours,[2] and therefore plays a major role in onset of action for orally administered drugs. For intravenous administration, the pathway is much shorter because the drug is administered (usually already in solution) directly to the bloodstream.

References[edit]

  1. ^ Pang, K. Sandy (2003). "MODELING OF INTESTINAL DRUG ABSORPTION: ROLES OF TRANSPORTERS AND METABOLIC ENZYMES (FOR THE GILLETTE REVIEW SERIES)". 
  2. ^ Bummer, Paul (2012). Gastro Intestinal Tract and Oral Drug Absorption. University of Kentucky. 



Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Onset_of_action — Please support Wikipedia.
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743 news items

 
Dakota Financial News
Fri, 22 May 2015 00:30:00 -0700

They wrote, “We believe CORI's transdermal technology may be able to deliver a faster onset of action and provide better tolerability than Forteo which is delivered as a once-daily subcutaneous injection. The second part of the Phase 2a study is a 28 ...
 
Seeking Alpha
Wed, 20 May 2015 09:41:15 -0700

The highest three doses also showed a rapid onset of action. The median time to achieve a clinically relevant improvement in lung function was 30 minutes. The mean reduction of rescue medication (inhaler) was more than one puff per day compared to ...

TheStreet.com

TheStreet.com
Thu, 14 May 2015 15:29:12 -0700

Galapagos is currently in the final phase of testing of a rheumatoid arthritis drug, filgotinib, which van de Stolpe claimed is easy to administer and needs less time to show results (just a week) than other treatments with "a long onset of action ...
 
MarketWatch
Wed, 20 May 2015 05:00:00 -0700

Importantly, data from our Phase 2b study of TD-4208 demonstrate a therapeutic profile that is consistent with once-daily dosing, an onset of action that provides prompt effect and the potential for a reduced dependence on short-acting rescue medication.
 
Solar Plaza (press release)
Thu, 21 May 2015 03:41:15 -0700

... advent of technological advancements such as improved anesthesia, tissue-sparing technologies, laparoscopic surgeries and genomics, make ambulatory centers well equipped to deliver efficient and fast services in order to provide fast onset of ...
 
Seeking Alpha
Tue, 05 May 2015 16:10:28 -0700

We believe that Endo's U.S. sales force deployment, promotional messaging, including the 15-minute onset of action data, and overall strategy for the brand will fully support STENDRA and further build the product. SPEDRA, as avanafil is known in the EU ...

FierceBiotech

FierceBiotech
Tue, 28 Apr 2015 07:37:30 -0700

Across both trials, the drug came through on its efficacy goals and demonstrated a fast onset of action, Galapagos Chief Scientific Officer Piet Wigerinck said, building the case for filgotinib as a disruptive force in RA. "These data support our ...
 
StreetInsider.com
Fri, 08 May 2015 06:08:50 -0700

We believe CORI's transdermal technology may be able to deliver a faster onset of action and provide better tolerability than Forteo which is delivered as a once-daily subcutaneous injection. The second part of the Phase 2a study is a 28-day take home ...
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