digplanet beta 1: Athena
Share digplanet:

Agriculture

Applied sciences

Arts

Belief

Business

Chronology

Culture

Education

Environment

Geography

Health

History

Humanities

Language

Law

Life

Mathematics

Nature

People

Politics

Science

Society

Technology

Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question. Other methods of ingestion such as smoking or injection can take as little as seconds to minutes to take effect. The determination of the onset of action, however, is not completely dependent upon route of administration. There are several other factors that determine the onset of action for a specific drug, including drug formulation, dosage, and the patient receiving the drug.

Effect of Administration Route on the Onset of Action[edit]

A drug's pharmacological effects can only occur once it has been fully solubilized and has entered the blood stream. For most drugs administered orally, the drug must be ingested, pass through the stomach, and into the small intestine, where the drug molecules enter the blood stream through the villi and microvilli.[1] Gastric emptying time can vary from 0 to 3 hours,[2] and therefore plays a major role in onset of action for orally administered drugs. For intravenous administration, the pathway is much shorter because the drug is administered (usually already in solution) directly to the bloodstream.

References[edit]

  1. ^ Pang, K. Sandy (2003). "MODELING OF INTESTINAL DRUG ABSORPTION: ROLES OF TRANSPORTERS AND METABOLIC ENZYMES (FOR THE GILLETTE REVIEW SERIES)". 
  2. ^ Bummer, Paul (2012). Gastro Intestinal Tract and Oral Drug Absorption. University of Kentucky. 



Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Onset_of_action — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.
72221 videos foundNext > 

Medication Onset of Action & Peak Effect

Medication Onset of Action & Peak Effect By Jason Ortiz & Eli Pumpian Pharmacology 3182.

The Increasing Incidence of Young Onset Colorectal Cancer A Call to Action

Dr. Whitney Jones from the University of Kentucky in Louisville, and Jasmine Greenamyer from the Colon Cancer Alliance in Washington, DC, discuss the article...

Inca Onset Performance Breakthrough

The Inca Onset represents a breakthrough in flatbed inkjet technology, and has forever changed the way in which display graphics are produced.

Pronounce Medical Words ― Onset Of Action

This video shows you how to say Onset Of Action. How would you pronounce Onset Of Action?

INCA Digital Onset Printer in Action at Tempt In-Store Productions

The most impressive flatbed Inca has introduced to date, the Onset is capable of delivering a print throughput up to 600sq.m/hr (6458sq.ft/hr), equivalent to...

How to Say or Pronounce Onset Of Action

Get those medical secrets: http://www.health101.pw/Medical-Secrets.shtml This video shows you how to say or pronounce Onset Of Action. Audio is from cancer.gov.

Middle Earth: Shadow Of Mordor - Stealth, Action and Random Onset Cowardice

Running on a GTX 660 with 2GB of vram, 8Gb ram, an 8-core 3.8 (overclocked) amd processor.

Onset Uzi action

Freeze the Action! - ON SET ep. 15

www.adorama.com Join us ONSET as we demonstrate action stopping flash duration while capturing a choreographed fight scene created especially for AdoramaPro ...

Celebrity Onset and AA Action Towing

Celebrity Onset is a one hour show featuring a diverse mixture of celebrity interviews, audience participation, and contests. Celebrity Onset will extend out...

72221 videos foundNext > 

698 news items

 
pharmabiz.com
Sat, 28 Feb 2015 00:26:15 -0800

Dermadexin SD Cream has been tested in two placebo-controlled, multicenter clinical trials (436 patients) where it displayed a marked and statistically significant effect on the symptoms of facial seborrhoeic dermatitis with a fast onset of action and ...
 
Seeking Alpha (registration)
Thu, 26 Feb 2015 09:15:00 -0800

Dermadexin has a unique "dual action" mechanism designed to offer rapid onset of action, high responder rate, and excellent safety profile. The dual mechanism comes from Astion's anti-neuro-inflammation technology that targets both the pathogenesis ...

My Yellowknife Now

My Yellowknife Now
Mon, 16 Feb 2015 16:29:39 -0800

We're seeing a younger group of patients who are struggling with the opioid addiction in relation to this medication because of its influx into Yellowknife over the last year.” “Fentanyl is a very strong narcotic. It has a very fast onset of action and ...
 
Stockhouse
Wed, 25 Feb 2015 00:26:15 -0800

... digestive enzymes reacting in the metabolic pathway. Formulations for other products often require higher doses and generally have a delayed onset of action. George R. Lefevre, CEO stated, "We are pleased to deploy our CBD line of dietary supplements.

Seeking Alpha (registration)

Seeking Alpha (registration)
Wed, 25 Feb 2015 08:25:10 -0800

With the excipients, BIOD-531 offers a rapid onset of action and a prolonged duration of action, making it suitable as a basal insulin. On January 7, positive results were announced from Study 3-151, a Phase 2a, single-blinded, 4-arm crossover ...
 
MarketWatch
Tue, 24 Feb 2015 13:00:00 -0800

"Concurrently, we have enhanced the value of our avanafil franchise with newly-approved differentiating language in the label regarding onset-of-action, and we remain focused on maintaining strong relationships with and among our worldwide alliance ...

Science World Report

Monthly Prescribing Reference
Thu, 18 Sep 2014 06:41:15 -0700

Vivus and Auxilium announced that the Food and Drug Administration (FDA) has approved a supplemental new drug application (sNDA) for Stendra (avanafil) to be taken ~15 minutes before sexual activity in the treatment of erectile dysfunction. Stendra ...
 
Lexology (registration)
Thu, 15 Jan 2015 09:03:19 -0800

The National Advertising Division (NAD) recently recommended that Novartis Consumer Health, Inc. discontinue advertising that its Theraflu product “starts to get to work in your body in 5 minutes.” NAD concluded that the claim communicates that ...
Loading

Oops, we seem to be having trouble contacting Twitter

Support Wikipedia

A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia. Please add your support for Wikipedia!

Searchlight Group

Digplanet also receives support from Searchlight Group. Visit Searchlight