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Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question. Other methods of ingestion such as smoking or injection can take as little as seconds to minutes to take effect. The determination of the onset of action, however, is not completely dependent upon route of administration. There are several other factors that determine the onset of action for a specific drug, including drug formulation, dosage, and the patient receiving the drug.
Effect of Administration Route on the Onset of Action
A drug's pharmacological effects can only occur once it has been fully solubilized and has entered the blood stream. For most drugs administered orally, the drug must be ingested, pass through the stomach, and into the small intestine, where the drug molecules enter the blood stream through the villi and microvilli. Gastric emptying time can vary from 0 to 3 hours, and therefore plays a major role in onset of action for orally administered drugs. For intravenous administration, the pathway is much shorter because the drug is administered (usually already in solution) directly to the bloodstream.
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Medication Onset of Action & Peak Effect By Jason Ortiz & Eli Pumpian Pharmacology 3182.
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Pronounce Medical Words ― Onset Of Action
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Joe Vinson, recurrent, 2013 Dianne G My son buys this item in the Vitamin Shoppe for me all the time, one a backup. Id had one sexual experience, a psychiatrist visits 2 days per week. Scott says July 5, and few lifeboats or rafts could be secured ...
GlobeNewswire (press release)
Mon, 17 Nov 2014 04:56:15 -0800
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Thu, 20 Nov 2014 04:00:00 -0800
"In my practice, I see ED patients that are looking for a safe and effective treatment with a rapid onset of action and a favorable side effect profile," said Laurence H. Belkoff, D.O., M.Sc., F.A.C.O.S., Chairman of the Department of Specialty ...
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Newswise (press release)
Thu, 20 Nov 2014 09:37:30 -0800
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PharmiWeb.com (press release)
Mon, 17 Nov 2014 00:15:00 -0800
Selective inhibition of JAK1 may combine favorable safety and clinical efficacy profiles with rapid onset of action. GLPG0634 is currently in a global Phase 2B program (DARWIN) in 875 RA patients and in a Phase 2 study in 180 patients with Crohn's disease.
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