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Not to be confused with Noma neonatorum.
Noma
Noma.png
A man afflicted with noma
Classification and external resources
ICD-9-CM 528.1
MedlinePlus 001342
MeSH D009625

Noma (also referred to as cancrum oris, fusospirochetal gangrene, necrotizing ulcerative stomatitis, stomatitis gangrenosa)[1] is a rapidly progressive, polymicrobial, often gangrenous infection of the mouth or genitals.

Causes[edit]

Fusobacterium necrophorum and Prevotella intermedia are thought to be key players in the process and interact with one or more other bacterial organisms (such as Borrelia vincentii, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Staphylococcus aureus, and nonhemolytic Streptococcus spp).[2]

The reported predisposing factors include:[3][4]

  • malnutrition (particularly A-and B-vitamins) or dehydration
  • poor hygiene, particularly oral
  • unsafe drinking water
  • proximity to unkempt livestock
  • recent illness
  • an immunodeficiency disease, including AIDS

Presentation[edit]

The mucous membranes of the mouth develop ulcers, and rapid, painless tissue degeneration ensues, which can degrade tissues of the bones in the face.[5]

In a condition sometimes called noma pudendi, noma can also cause tissue damage to the genitals.

Prognosis[edit]

The disease is associated with high morbidity and mortality[6] and mainly affects children under the age of twelve in the poorest countries of Africa. Children in Asia and some countries of South America are also affected. Most children who get the disease are between the ages of two and six years old.[7] The WHO estimates that 500,000 people are affected, and that 140,000 new cases are reported each year.[8] The mortality rate is approximately 90 percent.[1]

Treatment[edit]

Known in antiquity to such physicians as Hippocrates and Galen, noma was once reported around the world, including Europe and the United States. With improvements in hygiene and nutrition, noma has disappeared from industrialized countries since the 20th century, except during World War II when it was endemic to Auschwitz and Belsen concentration camps.[9] The disease and treatments were studied by Berthold Epstein, a Czech physician and forced-labor prisoner who had recommended the study under Josef Mengele's direction.[9]

The progression of the disease can be halted with the use of antibiotics and improved nutrition; however, its physical effects are permanent and may require oral and maxillofacial surgery or reconstructive plastic surgery to repair. Reconstruction is usually very challenging and should be delayed until full recovery (usually about one year following initial intervention). [10]

Children and other noma survivors in Africa are helped by a few international charitable organizations, such as Facing Africa, a UK registered charity that helps Ethiopian sufferers. There is one dedicated noma hospital in Nigeria, the Noma Children Hospital Sokoto, staffed by resident and visiting medical teams. In other countries, such as Ethiopia, international charities work in collaboration with the local health care system to provide complex reconstructive surgery which can give back facial functions such as eating, speaking and smiling. Teams of volunteer medics coming from abroad are often needed to support the local capacity to address the most severe cases, which can be extremely challenging even for senior maxillofacial surgeons.[11] On 10 June 2010 the work of such volunteer surgeons was featured in a UK BBC Two documentary presented by Ben Fogle, Make Me a New Face: Hope for Africa's Hidden Children.[12][13]

References[edit]

  1. ^ a b Marck, KW (2003). "A history of noma, the "Face of Poverty" (abstract)". Plast Reconstr Surg 111 (5): 1702–7. doi:10.1097/01.PRS.0000055445.84307.3C. PMID 12655218. 
  2. ^ Neville, Brad. Oral and Maxillofacial Pathology (3rd ed.). Saunders Book Company. pp. 062008. 5.11. 
  3. ^ Enwonwu CO (2006). "Noma--the ulcer of extreme poverty". N. Engl. J. Med. 354 (3): 221–4. doi:10.1056/NEJMp058193. PMID 16421362. 
  4. ^ Enwonwu CO, Falkler WA, Phillips RS (2006). "Noma (cancrum oris)". Lancet 368 (9530): 147–56. doi:10.1016/S0140-6736(06)69004-1. PMID 16829299. 
  5. ^ "AllRefer Health - Noma (Cancrum Oris, Gangrenous Stomatitis)". Retrieved 2007-07-12. 
  6. ^ Barmes DE, Enwonwu CO, Leclercq MH, Bourgeois D, Falkler WA (1997). "The need for action against oro-facial gangrene (noma)". Trop Med Int Health 2: 1111–1114. doi:10.1046/j.1365-3156.1997.d01-220.x. 
  7. ^ "The European Noma-Network". Retrieved 2007-07-12. 
  8. ^ Bourgeois DM, Leclercq MH (1999). "The World Health Organization initiative on noma". Oral Dis 5: 172–174. doi:10.1111/j.1601-0825.1999.tb00085.x. 
  9. ^ a b Lifton, Robert Jay (1986). The Nazi Doctors: Medical Killing and Psychological Genocide. Basic Books. p. 361. ISBN 0-465-04905-2. 
  10. ^ Neville, Brad. Oral and Maxillofacial Pathology, 3rd Edition. Saunders Book Company, 062008. 5.11.2
  11. ^ Project Harar - Medical care
  12. ^ Make Me a New Face: Hope for Africa's Hidden Children at bbc.co.uk
  13. ^ Ben Fogle » Blog Archive » Ben’s Documentary on Noma - BBC2

Further reading[edit]

The Surgical Treatment of noma by Kurt Boss and Klaas Marck. ISBN 978-90-71736-31-5

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Noma_(disease) — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.

18 news items

Yahoo News

Yahoo News
Fri, 03 Jul 2015 20:45:00 -0700

A young girl operated after suffering noma disease, poses for a photo at the health . View gallery . . . Zinder (Niger) (AFP) - Mourdja's nose has been eaten away, like one lip and part of her upper gum, leaving the 13-year-old girl atrociously ...
 
Vanguard
Mon, 08 Apr 2013 17:30:25 -0700

As cases of Noma disease progressively rise to alarming dimensions, Speaker of the House of Representative, Aminu Waziri Tambuwal, is flagging off an awareness campaign against the deadly disease on Monday, April 15 in Lagos, as an initiative of the ...
 
Axis of Logic
Tue, 17 Aug 2010 03:50:47 -0700

The following article is based on a report “The tragedy of Noma 1”, prepared by Mr. Jean Ziegler, Vice-President of the UN Human Rights Council Advisory Committee. Unless otherwise noted, the quotes in this article are excerpted from this report by Mr.

BBC News

BBC News
Tue, 27 Jan 2015 16:07:38 -0800

In another experiment, she says, the pair of them and more than 100 other twins were given injections of bacteria that cause Noma disease - an infection of the mouth or genitals, which causes boils and often turns gangrenous. Some twins became feverish ...

Le Huffington Post Quebec

Le Huffington Post Quebec
Fri, 19 Jun 2015 15:18:45 -0700

Son nez a disparu, tout comme sa lèvre et une partie de sa gencive supérieure, pour laisser place à une atroce béance : Mourdja, 13 ans, est défigurée par le noma, "maladie de la misère" causée par la malnutrition, très présente au Niger. "Avant, c ...

Manchester Evening News

Manchester Evening News
Sat, 24 Aug 2013 00:03:29 -0700

It's hard to believe that 24-year-old Sikyh Richardson, relaxing in her bikini in Marbella this summer, nearly lost her life four times to a devastating illness. Share; Share; Tweet; +1; LinkedIn. Get daily news by email. Invalid e-mail. Subscribe ...
 
CBS News
Wed, 24 Oct 2012 14:32:35 -0700

WARSAW, Poland The images are haunting: naked and emaciated children at Auschwitz standing shoulder-to-shoulder, adult prisoners in striped garb posing for police-style mug shots. Wilhelm Brasse, Auschwitz, prisoner, holocaust. This photograph ...

Lancashire Telegraph

Lancashire Telegraph
Fri, 16 Aug 2013 14:04:55 -0700

Bill Hamlin, consultant anaesthetist at East Lancashire Hospitals NHS Trust, will visit Ethiopia with a team surgeons and nurses to perform reconstructive surgery on patients suffering from noma disease – an extreme infection which severely disfigures ...
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