NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.
- ^ Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? Journal of Pharmacology and Experimental Therapeutics. 2006 Mar;316(3):1378-85. PMID 16352707
NS 2664 Leads NS 26G in Dalton, GA
8/17/2012 10:37 A.M. ET NS Atlanta North District North Dalton Milepost NS 39.9 Dalton, GA NS 26G rolls north through Dalton with an empty autorack train. NS...
Arlington, Texas - NS 2664 - 12/05/2011
12:13 MP 232.50 ZAILC-05 NS 2664 NS 9952 NS 2607 111-0.
CN 2664 Leads NS 61N in Waring, GA
3/6/2013 12:20 P.M. ET NS Atlanta North District Waring Milepost NS 36.2 Waring, GA NS 61N slowly eases south through Waring observing a 10 MPH slow order th...
CN 2664 Leads NS 61N in Collegedale, TN
3/6/2013 11:42 A.M. ET NS Atlanta North District Chestnut Creek Milepost NS 18.1 Collegedale, TN NS 61N rolls south through Collegedale with loads of molten ...
NS 2664 intermodal SouthEast bound Austel, GA.
NS 2664 & 8898 pull intermodal into Atlanta from Birmingham 4:29pm January 7, 2010.
CN 2664 Leads NS 61N in Dalton, GA
3/6/2013 12:44 P.M. ET NS Atlanta North District Phelps Milepost NS 45.1 Dalton, GA NS 61N flies by heading south at Phelps. Notice CSX A702 shoving south in...
CN 2664 Leads NS 61N in Cohutta, GA
3/6/2013 11:58 A.M. ET NS Atlanta North District Old Apison Pike Milepost NS 25.3 Cohutta, GA NS 61N speeds into Cohutta heading south down main 1. NS 61N CN...
CN 2664 Leads NS 61N in Chattanooga, TN
3/6/2013 10:47 A.M. ET NS Chattanooga Terminal Gate 8 - Harrison Pike Milepost NS 237.4 Chattanooga, TN NS 61N pulls to a stop at Brown coming off the CNO&TP...
HO Scale NS "Veterans" SD60E, SD70M, SD70M-2 locomotive consist - ABEL Modular, Shirley, MA 2013 - 3
The video shows a HO Scale consist of the Norfolk Southern 6920 "Honoring Our Veterans" SD60E, Norfolk Southern 2600 SD70M, and Norfolk Southern 2664 SD70M-2...
(HD) CN 2664 Leads NS 61N SB Sulpher (Brown-Talley) 3/6/13
On a bitter cold day we follow NS 61N a molten sulpher train bound for Florida. Once the train had arrive and swap crew at Brown it was going to me a 60 mile...
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