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NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.[1]
References [edit]
- ^ Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? Journal of Pharmacology and Experimental Therapeutics. 2006 Mar;316(3):1378-85. PMID 16352707
 NS 2664 Leads NS 26G in Dalton, GA 8/17/2012 10:37 A.M. ET NS Atlanta North District North Dalton Milepost NS 39.9 Dalton, GA NS 26G rolls north through Dalton with an empty autorack train. NS... |  Arlington, Texas - NS 2664 - 12/05/2011 12:13 MP 232.50 ZAILC-05 NS 2664 NS 9952 NS 2607 111-0. |  CN 2664 Leads NS 61N in Waring, GA 3/6/2013 12:20 P.M. ET NS Atlanta North District Waring Milepost NS 36.2 Waring, GA NS 61N slowly eases south through Waring observing a 10 MPH slow order th... |  CN 2664 Leads NS 61N in Collegedale, TN 3/6/2013 11:42 A.M. ET NS Atlanta North District Chestnut Creek Milepost NS 18.1 Collegedale, TN NS 61N rolls south through Collegedale with loads of molten ... |  NS 2664 intermodal SouthEast bound Austel, GA. NS 2664 & 8898 pull intermodal into Atlanta from Birmingham 4:29pm January 7, 2010. |  CN 2664 Leads NS 61N in Dalton, GA 3/6/2013 12:44 P.M. ET NS Atlanta North District Phelps Milepost NS 45.1 Dalton, GA NS 61N flies by heading south at Phelps. Notice CSX A702 shoving south in... |  CN 2664 Leads NS 61N in Cohutta, GA 3/6/2013 11:58 A.M. ET NS Atlanta North District Old Apison Pike Milepost NS 25.3 Cohutta, GA NS 61N speeds into Cohutta heading south down main 1. NS 61N CN... |  CN 2664 Leads NS 61N in Chattanooga, TN 3/6/2013 10:47 A.M. ET NS Chattanooga Terminal Gate 8 - Harrison Pike Milepost NS 237.4 Chattanooga, TN NS 61N pulls to a stop at Brown coming off the CNO&TP... |  HO Scale NS "Veterans" SD60E, SD70M, SD70M-2 locomotive consist - ABEL Modular, Shirley, MA 2013 - 3 The video shows a HO Scale consist of the Norfolk Southern 6920 "Honoring Our Veterans" SD60E, Norfolk Southern 2600 SD70M, and Norfolk Southern 2664 SD70M-2... |  (HD) CN 2664 Leads NS 61N SB Sulpher (Brown-Talley) 3/6/13 On a bitter cold day we follow NS 61N a molten sulpher train bound for Florida. Once the train had arrive and swap crew at Brown it was going to me a 60 mile... |
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