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mir-671
Identifiers
Symbol mir-671
Rfam RF00891
miRBase family MIPF0000358
Other data
RNA type microRNA
Domain(s) Eukaryota;

In molecular biology mir-671 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Alcoholic and Non-Alcoholic Fatty Liver Disease[edit]

miR-671 expression levels have been found to be vary significantly between the alcoholic and non-alcoholic forms of fatty liver disease.[1]

CDR1 regulation[edit]

miR-671 has been seen to negatively regulate the CDR1 (Cerebellar Degeneration-Related protein 1) gene, through the targeting and cleavage of a circular antisense transcript of the CDR1 locus. There is a partnered decrease in CDR1 mRNA levels with this downregulation.[2]

FN1 repression[edit]

miR-671 is able to bind to and repress fibronection type 1 (FN1) mRNA at its 3'untranslated region binding site.[3]

See also[edit]

References[edit]

  1. ^ Estep M, Armistead D, Hossain N, Elarainy H, Goodman Z, Baranova A et al. (2010). "Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease.". Aliment Pharmacol Ther 32 (3): 487–97. doi:10.1111/j.1365-2036.2010.04366.x. PMID 20497147. 
  2. ^ Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ et al. (2011). "miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA.". EMBO J 30 (21): 4414–22. doi:10.1038/emboj.2011.359. PMC 3230379. PMID 21964070. 
  3. ^ Rutnam ZJ, Yang BB (2012). "The non-coding 3' UTR of CD44 induces metastasis by regulating extracellular matrix functions.". J Cell Sci 125 (Pt 8): 2075–85. doi:10.1242/jcs100818. PMID 22637644. 

Further reading[edit]

1. [1] 2. [2]

  1. ^ Rutnam, Z. J.; Yang, B. B. (2012). "The non-coding 3' UTR of CD44 induces metastasis by regulating extracellular matrix functions". Journal of Cell Science 125 (8): 2075. doi:10.1242/jcs.100818. PMID 22393236.  edit
  2. ^ Hou, Q.; Huang, J.; Ju, Z.; Li, Q.; Li, L.; Wang, C.; Sun, T.; Wang, L.; Hou, M.; Hang, S.; Zhong, J. (2012). "Identification of Splice Variants, Targeted MicroRNAs and Functional Single Nucleotide Polymorphisms of theBOLA-DQA2Gene in Dairy Cattle". DNA and Cell Biology 31 (5): 739–744. doi:10.1089/dna.2011.1402. PMC 3358092. PMID 22084936.  edit

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Mir-671_microRNA_precursor_family — Please support Wikipedia.
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