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Methyl cellulose
Methyl cellulose.png
Other names
Cellulose, methyl ether; methylated cellulose; methylcellulose; E461
ATC code A06AC06
9004-67-5 YesY
ChemSpider  YesY
Molar mass variable
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY verify (what isYesY/N?)
Infobox references

Methyl cellulose (or methylcellulose) is a chemical compound derived from cellulose. It is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is sold under a variety of trade names and is used as a thickener and emulsifier in various food and cosmetic products, and also as a treatment of constipation. Like cellulose, it is not digestible, not toxic, and not an allergen.


Methyl cellulose does not occur naturally and is synthetically produced by heating cellulose with caustic solution (e.g. a solution of sodium hydroxide) and treating it with methyl chloride. In the substitution reaction that follows, the hydroxyl residues (-OH functional groups) are replaced by methoxide (-OCH3 groups).

Different kinds of methyl cellulose can be prepared depending on the number of hydroxyl groups substituted. Cellulose is a polymer consisting of numerous linked glucose molecules, each of which exposes three hydroxyl groups. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose. The theoretical maximum is thus a DS of 3.0, however more typical values are 1.3–2.6.

Different methyl cellulose preparations can also differ in the average length of their polymer backbones.

Solubility and temperature[edit]

Methyl cellulose has a lower critical solution temperature (LCST) between 40 °C and 50 °C. At temperatures below the LCST, it is readily soluble in water; above the LCST, it is not soluble, which has a paradoxical effect that heating a saturated solution of methyl cellulose will turn it solid, because methyl cellulose will precipitate out. The temperature at which this occurs depends on DS-value, with higher DS-values giving lower solubility and lower precipitation temperatures because the polar hydroxyl groups are masked.

Preparing a solution of methyl cellulose with cold water is difficult however: as the powder comes into contact with water, a gel layer forms around it, dramatically slowing the diffusion of water into the powder, hence the inside remains dry. A better way is to first mix the powder with hot water, so that the methyl cellulose particles are well dispersed (and so have a much higher effective surface area) in the water, and cool down this dispersion while stirring, leading to the much more rapid dissolution of those particles.


Methyl cellulose has an extremely wide range of uses, of which several are described below.

Consumer products[edit]

Thickener and emulsifier[edit]

Methyl cellulose is very occasionally added to hair shampoos, tooth pastes and liquid soaps, to generate their characteristic thick consistency. This is also done for foods, for example ice cream or croquette. Methyl cellulose is also an important emulsifier, preventing the separation of two mixed liquids because it is an emulsion stabilizer.

The E number of methyl cellulose as food additive is E464.

Methyl cellulose (AKA Methocel produced by Dow Chemical or Mecellose produced by Samsung Fine Chemicals) is also used as paint rheological modifier to prevent paint sagging problem.

Treatment of constipation[edit]

When eaten, methyl cellulose is not absorbed by the intestines but passes through the digestive tract undisturbed. It attracts large amounts of water into the colon, producing a softer and bulkier stool. It is used to treat constipation, diverticulosis, hemorrhoids and irritable bowel syndrome. It should be taken with sufficient amounts of fluid to prevent dehydration.

Because it absorbs water and potentially toxic materials and increases viscosity, it can also be used to treat diarrhea.

A well-known trade name of methyl cellulose when used as a drug is Citrucel by GlaxoSmithKline, but generic versions are also widely available.


Methyl cellulose is used as a variable viscosity personal lubricant; it is the main ingredient in K-Y Jelly.


The lubricating property of methyl cellulose is of particular benefit in the treatment of dry eyes (Keratoconjunctivitis Sicca).[1] Dry eyes are common in the elderly and is often associated with rheumatoid arthritis. The lacrimal gland and the accessory conjunctival glands produce fewer tears. Methyl cellulose may be used as a tear substitute.

Artificial tears and saliva[edit]

Solutions containing methyl cellulose or similar cellulose derivatives are used as substitute for tears or saliva if the natural production of these fluids is disturbed.

Nutritional supplement capsules[edit]

Methyl cellulose is used in the manufacture of capsules in nutritional supplements, its edible and nontoxic properties provide a vegetarian alternative to the use of gelatin.

Advanced cookery[edit]

Methyl cellulose, as a gel, has the unique property of setting when hot and melting when cold. The culinary potential of this property is currently being explored at the University of Nottingham.[2]

Construction materials[edit]

Methyl cellulose finds a major application as a performance additive in construction materials. It is added to mortar dry mixes to improve the mortar's properties such as workability, open and adjustment time, water retention, viscosity, adhesion to surfaces etc. Construction grade methyl cellulose is not to be identified with food and pharmaceutical grade methyl cellulose and hydroxypropyl methyl cellulose, since it may be cross-linked with glyoxal for easy dispersion in water.

The construction materials can be cement-based or gypsum-based. Notable examples of dry mixture mortars which utilize methyl cellulose include: tile adhesives, EIFS, insulating plasters, hand-trowed and machine sprayed plaster, stucco, self-leveling flooring, extruded cement panels, skim coats, joint & crack fillers, and tile grouts. Typical usage is about 0.2% – 0.5% of total dry powder weight for dry mixture.

Derivatives of methyl cellulose, which improve upon the performance characteristics, include hydroxypropyl methyl cellulose (HPMC) and hydroxyethyl methyl cellulose (HEMC). These derivatives typically improve the characteristics such as water retention, vertical surface slip-resistance, open time, etc.

Glue and binder[edit]

Methyl cellulose can be employed as a mild glue which can be washed away with water. This may be used in the fixation of delicate pieces of art as well as in book conservation to loosen and clean off old glue from spines and bookboards.

Methyl cellulose is the main ingredient in many wallpaper pastes. It is also used as a binder in pastel crayons and also as a binder in medications.

Paper and textile sizing[edit]

Methyl cellulose is used as sizing in the production of papers and textiles as it protects the fibers from absorbing water or oil.

Cell culture/virology[edit]

Methyl cellulose is also used in cell culture to study viral replication. It is dissolved in the same nutrient-containing medium in which cells are normally grown. A single layer of cells are grown on a flat surface, then infected with a virus for a short time. The strength of the viral sample used will determine how many cells get infected during this time. The thick methyl cellulose medium is then added on top of the cells in place of normal liquid medium. As the viruses replicate in the infected cells, they are able to spread between cells whose membrances touch each other, but are trapped when they enter the methyl cellulose. Only cells closely neighboring an infected cell will become infected and die. This leaves small regions of dead cells called plaques in a larger background of living uninfected cells. The number of plaques formed is determined by the strength of the original sample.

Bacterial motility inhibitor[edit]

Aqueous methyl cellulose solutions have been used to slow bacterial cell motility for closer inspection. Changing the amount of methyl cellulose in solution allows one to adjust the solution's viscosity.

Stem cell differentiation[edit]

Methyl cellulose is used in the most common approaches to quantify multiple or single lineage-committed hematopoietic progenitors, called colony-forming cells (CFCs) or colony-forming units (CFUs), in combination with culture supplements that promote their proliferation and differentiation, and allow the clonal progeny of a single progenitor cell to stay together and thus form a colony of more mature cells.


Methyl cellulose is used as a buffer additive in capillary electrophoresis to control electroosmotic flow for improved separations.

Special effects[edit]

The slimy, gooey appearance of an appropriate preparation of methyl cellulose with water, in addition to its nontoxic, nonallergenic, and edible properties, makes it popular for use in special effects for motion pictures and television wherever vile slimes must be simulated. In the film Ghostbusters, for example, the gooey substance the supernatural entities used to “slime” the Ghostbusters was mostly a thick water solution of methyl cellulose. The Aliens ooze and drip a great deal of methyl cellulose—especially the queen.

Methyl cellulose has been used to safely simulate molten materials, as well. In several of the Terminator films, it was back-lit with colored gels and films to reproduce the heated glow of iron in the large pouring ladles used to transport the metal from the smelting ovens to the various molds and forms. Methyl cellulose was also a stand-in for the lava flows on the volcanic surface of Mustafar, in Star Wars Episode III :Revenge of the Sith.

See also[edit]


  1. ^ Sandford-Smith, John (1995). Eye Diseases In Hot Climates. ELBS British Government. 
  2. ^ Blumenthal, Heston (19 November 2004). "The Appliance of Science (Melting Point)". The Guardian. Retrieved 8 August 2012. 
  • Cathleen Baker (1984). Methylcellulose & Sodium Carboxymethylcellulose: An Evaluation for Use in Paper Conservation through Accelerated Aging. Preprints of the Contributions to the Paris Congress, 2–8 September 1984: Adhesives and Consolidants, pp. 55–59. International Institute of Conservation.

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Methyl_cellulose — Please support Wikipedia.
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164 news items

New Zealand Herald
Fri, 27 Mar 2015 09:02:56 -0700

Sausage rolls are the sort of thing you eat on the run. A quick, hot snack to tide you over and for some people, like me, a rare treat to be smelled first, then eaten slowly and luxuriously, knowing full well that the next sausage roll will be a long ...
PR Newswire (press release)
Tue, 06 Jan 2015 03:10:18 -0800

The Global Methyl Cellulose Industry Report 2014 is a professional and in-depth study on the current state of the Methyl Cellulose industry. The report provides a basic overview of the industry including definitions, classifications, applications and ...

Columbus Dispatch

Columbus Dispatch
Mon, 02 Mar 2015 04:39:00 -0800

If you need a supplement, you might try methyl cellulose (such as Citrucel), wheat dextrin (such as Benefiber) and calcium polycarbophil (Fibercon). Q: In August, my right rotator cuff was repaired. I was told that the tear was severe, with bone and ...

Science 2.0

Science 2.0
Fri, 27 Feb 2015 07:42:57 -0800

A gluten-free diet, for example, will be 242 percent higher cost and the extra sugar, extra fat, hydroxypropyl methyl cellulose and xanthan gum in gluten-free foods are not a health positive. What about the whole food diet? The belief is that a whole ...
PR Newswire (press release)
Mon, 09 Mar 2015 08:45:00 -0700

... sucrose, starch, film-coated powder, 1,2-propylene glycol, polyvinylpyrrolidone (PVP), hydroxypropyl methyl cellulose (HPMC), microcrystalline cellulose, hydroxypropyl cellulose (HPC) and lactose rank as the top 10 pharmaceutical excipients in China.
PR Newswire (press release)
Wed, 24 Sep 2014 14:54:17 -0700

... non-ionic cellulose ether production is dominated by the United States, Japan and other developed countries, especially Dow Chemical, Ashland and ShinEtsu master about 75% of methylcellulose (MC) and hydroxypropyl methyl cellulose (HPMC) market.
Tue, 21 Aug 2012 12:16:40 -0700

The ingredient, known as SATISFIT-LTG, is a modified version of methyl cellulose, a food additive which has been used as a binding agent in ready meals, baked goods and other snack foods for 50 years. Methyl cellulose is a white powder which dissolves ...
Business Wire (press release)
Wed, 06 Aug 2014 23:45:00 -0700

The global non-ionic cellulose ether production is dominated by the United States, Japan and other developed countries, especially Dow Chemical, Ashland and ShinEtsu master about 75% of methylcellulose (MC) and hydroxypropyl methyl cellulose (HPMC) ...

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