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|Luisa de Guzmán|
|Portrait attributed to José de Avelar Rebelo|
|Tenure||1 December 1640 – 6 November 1656|
|Spouse||John IV of Portugal|
|Teodósio, Prince of Brazil
Joana, Princess of Beira
Catherine, Queen of England
Afonso VI, King of Portugal
Pedro II, King of Portugal
|House||House of Medina Sidonia
House of Braganza
|Father||Juan Manuel Pérez de Guzmán, 8th Duke of Medina Sidonia|
|Mother||Juana Lorenza de Sandoval y La Cerda|
31 October 1613|
|Died||27 February 1666
Lisbon, Kingdom of Portugal
Luisa Maria Francisca de Guzmán y Sandoval (Portuguese: Luísa Maria Francisca de Gusmão; 13 October 1613 – 27 February 1666) was a queen consort of Portugal. She was the spouse of King John IV, the first Braganza ruler, as well as the mother of two kings of Portugal (Afonso VI and Pedro II) and a queen of England (Catherine of Braganza). She served as regent of Portugal from 1656.
Luisa was Spanish by birth, the daughter of Juan Manuel Pérez de Guzmán, 8th Duke of Medina Sidonia, and Juana Lorenza Gomez de Sandoval y la Cerda. Her paternal grandfather was the renowned Alonso de Guzmán, "El Bueno". She married John in 1633.
Despite her Spanish roots, the ambitious Luisa guided her husband's policies during the Portuguese revolution against Habsburg Spain of 1640. She is considered the main influence behind his acceptance of the Portuguese throne when the Revolution seemed to tend to the Portuguese side. It is said that being warned of the dangers of becoming queen of a country that was to face Spain's might she pronounced the famous words:
- Antes rainha um dia (in some versions uma hora) que duquesa toda a vida.
- Rather queen for a day (in some versions an hour) than a duchess all my life.
In 1656, she was named Regent of the Kingdom after her husband's death and during the minority of her son Afonso VI. She continued to occupy the post even after Afonso became an adult because her son was mentally unstable. She was the target of a failed conspiracy headed by Luís de Vasconcelos e Sousa, Count of Castelo Melhor.
She defended the principles of freedom and independence of Portugal and controlled the government with a strong hand, fearing her son was incapable.
Luisa was mainly responsible for the diplomatic success of the new alliance with England. Her daughter Catherine married Charles II of England. She is also credited with the organization of the armies that in the following years would completely ensure Portuguese independence through the victories in the Portuguese Restoration War.
- Infante Teodósio, Prince of Brazil (8 February 1634 – 13 May 1653) died unmarried.
- Ana of Braganza (21 January 1635) died at birth.
- Infanta Joana, Princess of Beira (18 September 1635 – 17 November 1653) died unmarried.
- Catherine of Braganza (25 November 1638 – 31 December 1705) married Charles II of England and had no surviving issue.
- Manuel of Portugal (6 September 1640) died at birth.
- Afonso VI of Portugal (21 August 1643 – 12 September 1683) married Maria Francisca of Savoy.
- Pedro II of Portugal (26 April 1648 – 9 December 1706) married Maria Francisca of Savoy, had issue; married Maria Sophia of Neuburg and had issue.
Titles, styles, honours and arms 
Titles and styles 
- 13 October 1613 – 12 January 1633 Dona Luisa de Guzmán
- 12 January 1633 – 1 December 1640 Her Serene Highness The Duchess of Braganza
- 1 December 1640 – 6 November 1656 Her Majesty The Queen of Portugal and the Algarves
- 6 November 1656 – 27 February 1666 Her Majesty The Dowager Queen of Portugal and the Algarves
House of Braganza and the Ducal House of Guzmán
|Ancestors of Luisa de Guzmán|
Elisabeth of France
|Queen consort of Portugal
Title next held byMaria Francisca of Savoy