Lotions are applied to external skin with bare hands, a brush, a clean cloth, cotton wool, or gauze. While lotion may be used as a medicine delivery system, many lotions, especially hand lotions and body lotions are meant instead simply smooth, moisturize and soften the skin. These may be used in anti-aging lotions, which can also be classified as a cosmetic in many cases, and may contain fragrances. The Food and Drug Administration voiced concern about lotions not classified as drugs that advertise anti-aging or anti-wrinkle properties.
Dermatologists can prescribe lotions to treat or prevent skin diseases. It is not unusual for the same drug ingredient to be formulated into a lotion, cream and ointment. Creams are the most convenient of the three but are inappropriate for application to regions of hairy skin such as the scalp, while a lotion is less viscous and may be readily applied to these areas (many medicated shampoos are in fact lotions). Historically, lotions also had an advantage in that they may be spread thinly compared to a cream or ointment and may economically cover a large area of skin, but product research has steadily eroded this distinction. Non-comedogenic lotions are recommended for use on acne prone skin.
Lotions can be used for the delivery to the skin of medications such as:
- Anti-acne agents
- Soothing, smoothing, moisturizing or protective agents (such as calamine)
Since heath care workers must wash their hands frequently to prevent disease transmission, hospital grade lotion is recommended to prevent skin dermatitis caused by frequent exposure to cleaning agents in the soap. A 2006 study found that application of hospital grade lotion after hand washing significantly reduced skin roughness and dryness.
Most lotions are oil-in-water emulsions using a substance such as cetearyl alcohol to keep the emulsion together, but water-in-oil lotions are also formulated. The key components of a skin care lotion, cream or gel emulsion (that is mixtures of oil and water) are the aqueous and oily phases, an emulgent to prevent separation of these two phases, and, if used, the drug substance or substances. A wide variety of other ingredients such as fragrances, glycerol, petroleum jelly, dyes, preservatives, proteins and stabilizing agents are commonly added to lotions.
Since thickness and consistency are key factors in lotions and creams, it is important to understand the manufacturing process that determines viscosity.
Manufacturing lotions and creams can be completed in two cycles: 1. Emollients and lubricants are dispersed in oil with blending and thickening agents. 2. Perfume, color and preservatives are dispersed in the water cycle. Active ingredients are broken up in both cycles depending on the raw materials involved and the desired properties of the lotion or cream.
A typical oil-in-water manufacturing process might go like this:
• Step 1: Add flake/powder ingredients to the oil being used to prepare the oil phase.
• Step 2: Disperse active ingredients.
• Step 3: Prepare the water phase containing emulsifiers and stabilizers.
• Step 4: Mix the oil and water to form an emulsion. (Note: This is aided by heating to between 110-185 F (45-85 C) depending on the formulation and viscosity desired.)
• Step 5: Continue mixing until the end product is completed
Careful note should be taken in choosing the right mixing equipment for lotion manufacturing to avoid agglomerates and long processing times. It can make all the difference in manufacturing time and costs. Conventional agitators can present a number of problems including agglomerates and longer processing times. On the other hand, high shear in-line mixers can produce quality lotions and creams without many of the complications encountered with conventional mixers. Sonolation is also a process that is growing in popularity.
Potential health risks
There is currently no regulation over use of the term "hypoallergenic", and even pediatric skin products with the label were found to still contain allergens. Those with eczema are especially vulnerable to an allergic reaction with lotion, as their compromised skin barrier allows preservatives to bind with and activate immune cells.
The American Academy of Allergy, Asthma, and Immunology warns that lotion containing ingredients commonly found in food (such as goats milk, cow's milk, coconut milk, or oil) may introduce new allergies, and an allergic reaction when those foods are later consumed.
- Remington, Joseph Price (2006), Beringer, Paul, ed., Remington: The Science And Practice Of Pharmacy (21st ed.), Lippincott Williams & Wilkins, p. 772, ISBN 0781746736.
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