The liver receptor homolog-1 (LRH-1) also known as NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.[1][2] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.
LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3][4][5]
LRH-1 is important for maintaining pluripotence of stem cells during embryonic development.[6]
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Interactions [edit]
Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.[7][8]
References [edit]
- ^ Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Mol. Cell. Biol. 13 (3): 1619–33. PMC 359474. PMID 7680097.
- ^ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenet. Cell Genet. 82 (3–4): 269–70. doi:10.1159/000015116. PMID 9858833.
- ^ Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends Cell Biol. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.
- ^ Luo, Y.; Liang, C. P.; Tall, A. R. (2001). "The Orphan Nuclear Receptor LRH-1 Potentiates the Sterol-mediated Induction of the Human CETP Gene by Liver X Receptor". Journal of Biological Chemistry 276 (27): 24767–24773. doi:10.1074/jbc.M100912200. PMID 11331284.
- ^ Nitta, M. (1999). "CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha -hydroxylase gene". Proceedings of the National Academy of Sciences 96 (12): 6660–6665. doi:10.1073/pnas.96.12.6660.
- ^ Gu, P.; Goodwin, B.; Chung, A. C. -K.; Xu, X.; Wheeler, D. A.; Price, R. R.; Galardi, C.; Peng, L. et al. (2005). "Orphan Nuclear Receptor LRH-1 is Required to Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development". Molecular and Cellular Biology 25 (9): 3492–3505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC 1084298. PMID 15831456.
- ^ Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (September 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Mol. Endocrinol. 16 (9): 2065–76. doi:10.1210/me.2001-0194. PMID 12198243.
- ^ Lee YK, Moore DD (January 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.
Further reading [edit]
- Wong M, Ramayya MS, Chrousos GP, et al. (1997). "Cloning and sequence analysis of the human gene encoding steroidogenic factor 1". J. Mol. Endocrinol. 17 (2): 139–47. doi:10.1677/jme.0.0170139. PMID 8938589.
- Li M, Xie YH, Kong YY, et al. (1998). "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus". J. Biol. Chem. 273 (44): 29022–31. doi:10.1074/jbc.273.44.29022. PMID 9786908.
- Nitta M, Ku S, Brown C, et al. (1999). "CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6660–5. doi:10.1073/pnas.96.12.6660. PMC 21971. PMID 10359768.
- Goodwin B, Jones SA, Price RR, et al. (2000). "A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis". Mol. Cell 6 (3): 517–26. doi:10.1016/S1097-2765(00)00051-4. PMID 11030332.
- Wang ZN, Bassett M, Rainey WE (2001). "Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase". J. Mol. Endocrinol. 27 (2): 255–8. doi:10.1677/jme.0.0270255. PMID 11564608.
- Zhang CK, Lin W, Cai YN, et al. (2001). "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene". Gene 273 (2): 239–49. doi:10.1016/S0378-1119(01)00586-8. PMID 11595170.
- Lee YK, Moore DD (2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176.
- Clyne CD, Speed CJ, Zhou J, Simpson ER (2002). "Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes". J. Biol. Chem. 277 (23): 20591–7. doi:10.1074/jbc.M201117200. PMID 11927588.
- Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/me.16.6.1367. PMID 12040021.
- Sirianni R, Seely JB, Attia G, et al. (2002). "Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes". J. Endocrinol. 174 (3): R13–7. doi:10.1677/joe.0.174R013. PMID 12208674.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA (2003). "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1". Mol. Cell 11 (6): 1575–85. doi:10.1016/S1097-2765(03)00236-3. PMID 12820970.
- Privalsky ML (2003). "Activation incarnate". Dev. Cell 5 (1): 1–2. doi:10.1016/S1534-5807(03)00196-5. PMID 12852843.
- Fayard E, Schoonjans K, Annicotte JS, Auwerx J (2003). "Liver receptor homolog 1 controls the expression of carboxyl ester lipase". J. Biol. Chem. 278 (37): 35725–31. doi:10.1074/jbc.M302370200. PMID 12853459.
- Annicotte JS, Fayard E, Swift GH, et al. (2003). "Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development". Mol. Cell. Biol. 23 (19): 6713–24. doi:10.1128/MCB.23.19.6713-6724.2003. PMC 193920. PMID 12972592.
- Peng N, Kim JW, Rainey WE, et al. (2004). "The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II". J. Clin. Endocrinol. Metab. 88 (12): 6020–8. doi:10.1210/jc.2003-030880. PMID 14671206.
- Cai YN, Zhou Q, Kong YY, et al. (2004). "LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication". Cell Res. 13 (6): 451–8. doi:10.1038/sj.cr.7290187. PMID 14728801.
- Saxena D, Safi R, Little-Ihrig L, Zeleznik AJ (2004). "Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation". Endocrinology 145 (8): 3821–9. doi:10.1210/en.2004-0423. PMID 15117876.
External links [edit]
- NR5A2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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