The following are the family Houses featured in the fictional Dune universe created by Frank Herbert. The assembly of all the nobles in the Imperium, called the Landsraad, consists of many additional Houses Great or Minor which are never mentioned in the novels.
House Atreides 
House Atreides is one of the Great Houses of the feudal interstellar empire known as the Imperium; its members play a role in every novel in the series, starting with 1965's Dune. Leto Atreides II notes in God Emperor of Dune (1981) that the Atreides are descended from the mythological Greek House of Atreus. In Homer's Iliad, the brothers Agamemnon and Menelaus are dubbed "the Atreides," or "sons of Atreus;" Leto's twin sister Ghanima mentions Agamemnon as a direct ancestor in Children of Dune (1976). However, in Dune: The Butlerian Jihad (2002) it is suggested that she is instead referring to the leader of the group of Titans named Agamemnon.
Boro family 
Boro is the surname of Camie Boro, the last descendant of the last Emperor who ruled the Old Empire before its downfall at the hands of the Titans, as established in the Legends of Dune prequel trilogy (2002-2004) by Brian Herbert and Kevin J. Anderson.
During the Butlerian Jihad, Iblis Ginjo marries Camie as part of his plan to ascend in the League of Nobles. Their great-granddaughter Jessica Boro-Ginjo would later marry Faykan Corrino, the first Padishah Emperor, making future members of House Corrino and House Harkonnen descendants of the Boro family.
House Corrino 
House Corrino is the Great House whose members rule the Known Universe as Padishah Emperors for 10,000 years until Shaddam Corrino IV is deposed by Paul Atreides in Dune. The Corrinos play a role in Frank Herbert's initial three novels — Dune (1965), Dune Messiah (1969) and Children of Dune (1976) — as well as the Brian Herbert/Kevin J. Anderson prequel trilogy Prelude to Dune (1999-2001) and interquel series Heroes of Dune (2008-2011).
House Ecaz 
House Ecaz rules the fourth planet of Alpha Centauri B, also named Ecaz. During the events of Prelude to Dune and the interquel novel Paul of Dune (2008), the head of the House is Archduke Armand Ecaz; at this time, House Ecaz is in kanly, or vendetta, with House Moritani.
House Fenring 
House Hagal 
As noted in the Prelude to Dune series, House Hagal allies itself with the Imperial House Corrino when Padishah Emperor Elrood IX weds Yvette Hagal. Their daughter Edwina is later the great-grandmother of Paul Atreides. The planet Hagal had once been rich in gems before being "mined out in the time of Shaddam I."
House Ginaz 
It is noted in Dune that House Ginaz are "one-time allies of Duke Leto Atreides" and are "defeated in the War of Assassins with Grumman." Duncan Idaho is noted to be a "Swordmaster of the Ginaz," which leads to his body later being sold to the Tleilaxu as "a master swordsman, an adept of the Ginaz School."
House Harkonnen 
The Harkonnens are the longtime enemies of House Atreides, and conspire with Shaddam against them in Dune.
House Moritani 
Prelude to Dune establishes that immediately prior to the events in Dune, House Moritani are at war with House Ecaz. In the year 10,175 A.G., the Viscount Hundro Moritani allies with House Harkonnen in an attempt to conquer the Atreides homeworld of Caladan; the attempt fails when the Atreides Mentat Thufir Hawat tricks the Moritani/Harkonnen forces into believing that the Atreides have a gigantic water fleet, which are actually harmless fishing boats. House Moritani also attacks the planet Ginaz after some of their students are sent home in disgrace from their renowned Swordmaster School.
Paul of Dune reveals that House Moritani is secretly descended from House Tantor, the renegade house who had devastated Salusa Secundus with atomics and who had been subsequently "exterminated" by Padishah Emperor Hassik Corrino III. Their name disappears from written history. It had been established in the Legends of Dune trilogy that prior to the Butlerian Jihad, the Tantor family had adopted an orphaned Xavier Harkonnen.
House Mutelli 
House Mutelli also weds one of its own, Barbara, to Padishah Emperor Elrood IX prior to the Prelude to Dune series.
House Novebruns 
The planet Novebruns is noted in Children of Dune when Gurney Halleck recounts that "three hundred and twenty-one liters [of melange] were said to have bought half of Novebruns Planet from the Mutelli family." In the prequel Dune: House Corrino (2001), the Lord of House Novebruns formally requests that Shaddam IV grant the destroyed House Taligari world of Zanovar to him so that he can mine it for "valuable raw materials."
House Ordos 
House Richese 
House Taligari 
In the Prelude to Dune series, House Taligari is the adoptive family of Tyros Reffa, illegitimate son of Padishah Emperor Elrood Corrino IX and his concubine Shando Balut. The Taligari homeworld is the recreational planet Zanovar, devastated by Elrood's son Shaddam in an attempt to eliminate Tyros.
House Vernius 
- Herbert, Frank (1965). Dune.
- Herbert, Frank (1981). God Emperor of Dune.
- Herbert, Frank (1976). Children of Dune.
- Herbert, Brian; Kevin J. Anderson (2002-2004). Legends of Dune.
- Herbert, Frank (1969). Dune Messiah.
- Herbert, Brian (1999-2001). Prelude to Dune.
- Herbert, Frank (1965). "Terminology of the Imperium: ECAZ". Dune.
- Herbert, Brian; Kevin J. Anderson (2008). Paul of Dune. ISBN 0-7653-1294-8.
- Herbert, Frank (1965). "Terminology of the Imperium: HAGAL". Dune.
- Herbert, Frank (1965). "Terminology of the Imperium: GINAZ, HOUSE OF". Dune.
- Herbert, Frank (1965). "Terminology of the Imperium: GRUMMAN". Dune.
- Herbert, Brian; Kevin J. Anderson (2001). Dune: House Corrino.
- McNelly, Willis E. (June 1, 1984). "GREAT HOUSES, THE". The Dune Encyclopedia. p. 273. ISBN 0-425-06813-7 (US edition).
- Herbert, Frank (1965). "Terminology of the Imperium: RICHESE". Dune.