Learn and talk about Leukotriene B4 receptor 2, G protein coupled receptors, Human proteins

Leukotriene B4 receptor 2

Identifiers

LTB4R2; BLT2; BLTR2; JULF2; KPG_004; LTB4-R 2; LTB4-R2; NOP9

External IDs

OMIM: 605773 MGI: 1888501 HomoloGene: 10519 IUPHAR: BLT₂ ChEMBL: 3191 GeneCards: LTB4R2 Gene

Gene Ontology
Molecular function	• leukotriene receptor activity
Cellular component	• plasma membrane • integral to plasma membrane
Biological process	• chemotaxis • negative regulation of adenylate cyclase activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
24.77 – 24.78 Mb

Chr 14:
55.76 – 55.76 Mb

PubMed search

[1]

[2]

Leukotriene B4 receptor 2 is a protein that in humans is encoded by the LTB4R2 gene.^[1]^[2]^[3]

This is a low-affinity receptor for leukotrienes, especially leukotriene B4. It mediates chemotaxis of granulocytes and macrophages.

1 See also
2 References
3 External links
4 Further reading
5 External links

References [edit]

^ Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T (Jan 2001). "A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization". J Biol Chem 275 (52): 40686–94. doi:10.1074/jbc.M004512200. PMID 11006272.
^ Kato K, Yokomizo T, Izumi T, Shimizu T (Sep 2000). "Cell-Specific Transcriptional Regulation of Human Leukotriene B4 Receptor Gene". J Exp Med 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229.
^ "Entrez Gene: LTB4R2 leukotriene B4 receptor 2".

External links [edit]

"Leukotriene Receptors: BLT₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

External links [edit]

IUPHAR GPCR Database - Leukotriene receptors
LTB4R2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
Receptors, Leukotriene B4 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

Cell surface receptor: G protein-coupled receptors

Class A:
Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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Leukotriene B4 receptor 2

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