John P. A. Ioannidis (born August 21, 1965 in New York City) is a Professor of Health Research and Policy at Stanford School of Medicine, the University's Rehnborg Chair in Disease Prevention and director of its Prevention Research Center, and co-director, along with Steven Goodman, of the Meta-Research Innovation Center at Stanford (METRICS). He was chairman at the Department of Hygiene and Epidemiology, University of Ioannina School of Medicine as well as adjunct professor at Tufts University School of Medicine. He is best known for his research and published papers on scientific studies, particularly the 2005 paper "Why Most Published Research Findings Are False".
Ioannidis (2005) Why Most Published Research Findings Are False.
Born in New York City in 1965, Ioannidis was raised in Athens, Greece. He was Valedictorian of his class at Athens College, graduating in 1984. He also graduated first in his class at the University of Athens Medical School, then attended Harvard University for his medical residency in internal medicine. He did a fellowship at Tufts University for infectious disease.
Ioannidis's 2005 paper "Why Most Published Research Findings Are False" has been the most downloaded technical paper from the journal PLoS Medicine. A profile of his work in this area appears in the November 2010 issue of The Atlantic. The Atlantic article notes Ioannidis analyzed "49 of the most highly regarded research findings in medicine over the previous 13 years". In the paper Ioannidis compared the 45 studies that claimed to have uncovered effective interventions with data from subsequent studies with larger sample sizes: 7 (16%) of the studies were contradicted, 7 (16%) the effects were smaller than in the initial study, 20 (44%) were replicated and 11 (24%) of the studies remained largely unchallenged.
Statisticians Goodman and Greenland agreed that "many medical research findings are less definitive than readers suspect" but disputed his headline claims as unsupportable by the methods used. Ioannidis responded to this critique and other researchers have generally supported the general thrust of his findings. Ioannidis' work is focused on improving research design standards.
He coined the term Proteus phenomenon for the tendency of replication studies to refute their parent.
- ^ "John P. A. Ioannidis". Stanford School of Medicine CAP Profiles. Retrieved May 24, 2014.
- ^ "Prevention Research Center". Stanford School of Medicine. Retrieved May 24, 2014.
- ^ "John P. A. Ioannidis". Department of Hygiene and Epidemiology, University of Ioannina School of Medicine. Retrieved 2008-12-31.
- ^ Ioannidis, John P.A. "Curriculum Vitae". Retrieved 4 November 2010.
- ^ a b c Ioannidis, J. P. A. (2005). "Why Most Published Research Findings Are False". PLoS Medicine 2 (8): e124. doi:10.1371/journal.pmed.0020124. PMC 1182327. PMID 16060722.
- ^ John Ioannidis Harvard School of Public Health
- ^ David H. Freedman (2010). Wrong: Why Experts Keep Failing Us. Little, Brown and Company. ISBN 0-316-02378-7.
Born in 1965 in the United States to parents who were both physicians, he was raised in Athens, where he showed unusual aptitude in mathematics and snagged Greece's top student math prize. ...
- ^ Robert Lee Hotz (2007-09-14). "Most Science Studies Appear to Be Tainted By Sloppy Analysis". Science Journal WSJ.com (Dow Jones & Company).
- ^ David H. Freedman (November 2010) Lies, Damned Lies, and Medical Science, The Atlantic
- ^ Steven Goodman and Sander Greenland (2007). "Assessing the unreliability of the medical literature: A response to "Why most published research findings are false"". Johns Hopkins University, Department of Biostatistics.
- ^ Goodman, S.; Greenland, S. (2007). "Why Most Published Research Findings Are False: Problems in the Analysis". PLoS Medicine 4 (4): e168. doi:10.1371/journal.pmed.0040168. PMC 1855693. PMID 17456002.
- ^ Ioannidis, J. P. A. (2007). "Why Most Published Research Findings Are False: Author's Reply to Goodman and Greenland". PLoS Medicine 4 (6): e215. doi:10.1371/journal.pmed.0040215. PMC 1896210. PMID 17593900.
- ^ New Truths That Only One Can See January 20, 2014 New York Times
- ^ "Unreliable research: Trouble at the lab". The Economist. October 19, 2013.
- Prevention Research Center Stanford School of Medicine
- Publications of John Ioannidis Stanford University Profile
- Increasing value and reducing waste in research design, conduct, and analysis The Lancet, Volume 383, Issue 9912, Pages 166 - 175, 11 January 2014 John P A Ioannidis, Sander Greenland, Mark A Hlatky, Muin J Khoury, Malcolm R Macleod, David Moher, Kenneth F Schulzand Robert Tibshirani
- Szgene.org, meta-analytic database of schizophrenia gene studies of which Dr. Ioannidis helped create.
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John P.A. Ioannidis, MD, DSc, is a Professor of Medicine, Health Research and Policy, and Statistics at Stanford University. He is also the founding Director...
Why Most Published Research Findings Are False
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On April 2, 2013, Stanford's Center for Law and the Biosciences hosted an afternoon discussion with Dr. John Ioannidis on "The Reliability of Biomedical Evid...
Prof. John Ioannidis on research inefficiencies
The Meta-Research Innovation Center at Stanford (METRICS) is a research-to-action center whose purpose is to advance excellence in scientific research. In th...
Reproducibility Workshop Panel 12 - Ioannidis, Braunschweiger, Poirier
John P. A. Ioannidis, Paul Braunschweiger, and Ghislaine Poirier present on the mechanisms by which the academic and commercial sectors can build bridges of ...
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EurekAlert (press release)
Tue, 13 Jan 2015 15:33:21 -0800
... whether this [widespread screening] is a good idea," write the authors, which include lead author Jeanne Lenzer, an investigative medical journalist, and physicians Ronald L. Koretz, MD, of David Geffen-UCLA School of Medicine; John P. A. Ioannidis ...
Mon, 03 Nov 2014 11:13:25 -0800
John P. A. Ioannidis is the C. F. Rehnborg Professor in Disease Prevention and professor of medicine, of health research and policy, and of statistics at Stanford University. Along with Steven Goodman, he co-founded the Meta-Research Innovation Center ...
Thu, 13 Nov 2014 03:54:48 -0800
On the morning of March 2, 2005, a 14-year-old Japanese girl woke up scared. At first she thought someone was outside the house watching her, but then she decided the stranger must be inside. She wandered restlessly and, despite the cold weather, threw ...
Wall Street Journal
Wall Street Journal
Wed, 13 Aug 2014 14:11:42 -0700
John P. A. Ioannidis is in the Department of Hygiene and Epidemiology, University of Ioannina School of. Medicine, Ioannina, Greece, and Institute for Clinical Research and Health Policy Studies, Department of. Medicine, Tufts-New England Medical ...
University World News
Sat, 14 Jun 2014 01:57:25 -0700
A group of leading medical journal editors, convened by the National Institutes of Health, last week endorsed a set of guidelines intended to tackle the widespread problem of scientific findings that cannot be replicated, writes Paul Basken for The ...
Fabius Maximus (blog)
Fabius Maximus (blog)
Fri, 10 Oct 2014 08:09:54 -0700
“Most scientific papers are probably wrong“, Kurt Kleiner, New Scientist, 30 August 2005; “Why Most Published Research Findings Are False“, John P. A. Ioannidis, Public Library of Science Medicine, 30 August 2005; “Reliability of 'new drug target ...
Chronicle of Higher Education (subscription)
Fri, 06 Jun 2014 02:26:47 -0700
A landmark moment came in 2005, when John P.A. Ioannidis, a professor of medicine at Stanford University, published an analysis in PLOS Medicine concluding that most published research findings appeared to be substantially false. Dr. Collins and his ...
New York Times
Fri, 07 Mar 2014 15:06:13 -0800
Featured in the piece was a study by Dr. John P.A. Ioannidis that has been a source of contention since it appeared in 2005. It was called “Why Most Published Research Findings Are False.” All scientific results are, of course, subject to revision and ...
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