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John P. A. Ioannidis (born August 21, 1965 in New York City) is a Professor of Health Research and Policy at Stanford School of Medicine, the University's Rehnborg Chair in Disease Prevention and director of its Prevention Research Center, and co-director, along with Steven Goodman, of the Meta-Research Innovation Center at Stanford (METRICS).[1][2] He was chairman at the Department of Hygiene and Epidemiology, University of Ioannina School of Medicine as well as adjunct professor at Tufts University School of Medicine.[3][4] He is best known for his research and published papers on scientific studies, particularly the 2005 paper "Why Most Published Research Findings Are False".


Ioannidis (2005) Why Most Published Research Findings Are False.[5]

Born in New York City in 1965, Ioannidis was raised in Athens, Greece.[6] He was Valedictorian of his class at Athens College, graduating in 1984. He also graduated first in his class at the University of Athens Medical School, then attended Harvard University for his medical residency in internal medicine. He did a fellowship at Tufts University for infectious disease.[7]

Research findings[edit]

Ioannidis's 2005 paper "Why Most Published Research Findings Are False"[5] has been the most downloaded technical paper from the journal PLoS Medicine.[8] A profile of his work in this area appears in the November 2010 issue of The Atlantic.[9] The Atlantic article notes Ioannidis analyzed "49 of the most highly regarded research findings in medicine over the previous 13 years". In the paper Ioannidis compared the 45 studies that claimed to have uncovered effective interventions with data from subsequent studies with larger sample sizes: 7 (16%) of the studies were contradicted, 7 (16%) the effects were smaller than in the initial study, 20 (44%) were replicated and 11 (24%) of the studies remained largely unchallenged.[5]

Statisticians Goodman and Greenland agreed that "many medical research findings are less definitive than readers suspect" but disputed his headline claims as unsupportable by the methods used.[10][11] Ioannidis responded to this critique[12] and other researchers have generally supported the general thrust of his findings.[13][14] Ioannidis' work is focused on improving research design standards.

He coined the term Proteus phenomenon for the tendency of replication studies to refute their parent.

See also[edit]


  1. ^ "John P. A. Ioannidis". Stanford School of Medicine CAP Profiles. Retrieved May 24, 2014. 
  2. ^ "Prevention Research Center". Stanford School of Medicine. Retrieved May 24, 2014. 
  3. ^ "John P. A. Ioannidis". Department of Hygiene and Epidemiology, University of Ioannina School of Medicine. Retrieved 2008-12-31. 
  4. ^ Ioannidis, John P.A. "Curriculum Vitae". Retrieved 4 November 2010. 
  5. ^ a b c Ioannidis, J. P. A. (2005). "Why Most Published Research Findings Are False". PLoS Medicine 2 (8): e124. doi:10.1371/journal.pmed.0020124. PMC 1182327. PMID 16060722.  edit
  6. ^ John Ioannidis Harvard School of Public Health
  7. ^ David H. Freedman (2010). Wrong: Why Experts Keep Failing Us. Little, Brown and Company. ISBN 0-316-02378-7. Born in 1965 in the United States to parents who were both physicians, he was raised in Athens, where he showed unusual aptitude in mathematics and snagged Greece's top student math prize. ... 
  8. ^ Robert Lee Hotz (2007-09-14). "Most Science Studies Appear to Be Tainted By Sloppy Analysis". Science Journal WSJ.com (Dow Jones & Company). 
  9. ^ David H. Freedman (November 2010) Lies, Damned Lies, and Medical Science, The Atlantic
  10. ^ Steven Goodman and Sander Greenland (2007). "Assessing the unreliability of the medical literature: A response to "Why most published research findings are false"". Johns Hopkins University, Department of Biostatistics. 
  11. ^ Goodman, S.; Greenland, S. (2007). "Why Most Published Research Findings Are False: Problems in the Analysis". PLoS Medicine 4 (4): e168. doi:10.1371/journal.pmed.0040168. PMC 1855693. PMID 17456002.  edit
  12. ^ Ioannidis, J. P. A. (2007). "Why Most Published Research Findings Are False: Author's Reply to Goodman and Greenland". PLoS Medicine 4 (6): e215. doi:10.1371/journal.pmed.0040215. PMC 1896210. PMID 17593900.  edit
  13. ^ New Truths That Only One Can See January 20, 2014 New York Times
  14. ^ "Unreliable research: Trouble at the lab". The Economist. October 19, 2013. 

External links[edit]

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/John_P._A._Ioannidis — Please support Wikipedia.
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91 news items

Chronicle of Higher Education (subscription)
Wed, 10 Dec 2014 02:51:18 -0800

The author, John P.A. Ioannidis, warns that because of the built-in inefficiencies and perverse reward mechanisms of academic publishing, "the majority of research effort is currently wasted." He's been sounding the alarm bell on that topic for a long ...
Scientific American
Mon, 03 Nov 2014 11:13:25 -0800

John P. A. Ioannidis is the C. F. Rehnborg Professor in Disease Prevention and professor of medicine, of health research and policy, and of statistics at Stanford University. Along with Steven Goodman, he co-founded the Meta-Research Innovation Center ...
Managed Care magazine
Wed, 05 Nov 2014 05:29:20 -0800

Researchers and physicians are questioning the validity of information presented in the medical literature, saying that many of the findings presented are prone to bias or just plain wrong. In his much-publicized 2005 review, John P.A. Ioannidis, MD ...
University World News
Sat, 14 Jun 2014 01:57:25 -0700

A group of leading medical journal editors, convened by the National Institutes of Health, last week endorsed a set of guidelines intended to tackle the widespread problem of scientific findings that cannot be replicated, writes Paul Basken for The ...
Молодий Буковинець
Tue, 18 Nov 2014 23:52:30 -0800

Серед шукачів наукових знань було п'ятеро студентів Буковинського державного медичного університету. Спікерами ключових лекцій були: Prof. Amit Meller, Prof. Barry R Bloom, Prof. John P.A. Ioannidis, Prof. Marianne Legato, Prof. Ulrich Dirnagl.

Wall Street Journal

Wall Street Journal
Wed, 13 Aug 2014 14:11:42 -0700

John P. A. Ioannidis is in the Department of Hygiene and Epidemiology, University of Ioannina School of. Medicine, Ioannina, Greece, and Institute for Clinical Research and Health Policy Studies, Department of. Medicine, Tufts-New England Medical ...

Fabius Maximus (blog)

Fabius Maximus (blog)
Fri, 10 Oct 2014 08:09:54 -0700

“Most scientific papers are probably wrong“, Kurt Kleiner, New Scientist, 30 August 2005; “Why Most Published Research Findings Are False“, John P. A. Ioannidis, Public Library of Science Medicine, 30 August 2005; “Reliability of 'new drug target ...
New York Times
Fri, 07 Mar 2014 15:06:13 -0800

Featured in the piece was a study by Dr. John P.A. Ioannidis that has been a source of contention since it appeared in 2005. It was called “Why Most Published Research Findings Are False.” All scientific results are, of course, subject to revision and ...

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