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Isabella Karle
Isabella Karle.jpg
Born Isabella Helen Lugoski
(1921-12-02) December 2, 1921 (age 92)
Detroit, Michigan
Nationality United States
Fields Crystallography
Alma mater University of Michigan
Notable awards Garvan–Olin Medal (1978)
Gregori Aminoff Prize (1988)
Bower Award (1993)
National Medal of Science (1995)
Spouse Jerome Karle (m. 1942; 3 children)

Isabella Helen Lugoski Karle (born December 2, 1921) is an American x-ray crystallographer. In 1969 she established the structure of venom extracted from South American frogs. This was followed in 1975 with the structure of valinomycin.[1]

Life and career[edit]

Born Isabella Helen Lugoski in Detroit, Michigan, USA, on December 2, 1921, the daughter of immigrants from Poland, she attended the local public schools, where a female chemistry teacher led her to her pursuit of the field as a career.[2] She attended the University of Michigan on full scholarship, where she majored in physical chemistry and received a Bachelor of Science at age 19, followed by Master of Science and Ph.D. degrees in the field. She worked on the Manhattan Project during World War II, where she developed techniques to extract plutonium chloride from a mixture containing plutonium oxide.[3]

She joined the United States Naval Research Laboratory after the end of the war. Karle advanced the practical uses of the work her husband, Nobel Prize winner Jerome Karle, did on using X-ray scattering techniques to directly determine the structure of crystals, a technique that is used to study the biological, chemical, metallurgical and physical characteristics, allowing processes to be designed to duplicate the molecules being studied. This technique has played a major role in the development of new pharmaceutical products and other synthesized materials.[3] She was elected a Fellow of the American Academy of Arts and Sciences in 1993.[4]

Isabella (seated center) and Jerome Karle (left foreground) at their 2009 retirement ceremony

On July 31, 2009, she and her husband retired from the Naval Research Laboratory, after a combined 127 years of service to the United States Government, with Karle joining the NRL in 1946, two years after her husband.[3] Retirement ceremonies for the Karles were attended by United States Secretary of the Navy Ray Mabus, who presented the couple with the Department of the Navy Distinguished Civilian Service Award, the Navy's highest form of recognition to civilian employees.[3]

References[edit]

  1. ^ Karle, I L (March 1973). "Successful women in the sciences: analysis of determinants. I. Individual life experiences. Crystallographer". Ann. N. Y. Acad. Sci. (UNITED STATES) 208 (1 Successful Wo): 11–4. Bibcode:1973NYASA.208...11K. doi:10.1111/j.1749-6632.1973.tb30812.x. ISSN 0077-8923. PMID 4572877. 
  2. ^ Staff. " profile", Journal of Chemical Education. Accessed September 22, 2009.
  3. ^ a b c d McKinney, Donna. "Jerome and Isabella Karle Retire from NRL Following Six Decades of Scientific Exploration", United States Naval Research Laboratory press release dated July 21, 2009. Accessed September 22, 2009.
  4. ^ "Book of Members, 1780–2010: Chapter K". American Academy of Arts and Sciences. Retrieved July 29, 2014. 

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Isabella_Karle — Please support Wikipedia.
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10 news items

The Week Magazine

The Week Magazine
Sat, 15 Nov 2014 11:05:07 -0800

What Isabella Karle's fellow shoppers don't know as they wait beside her in the checkout line is that she revolutionized the method of discovering the medicines that many of them regularly purchase over at the pharmacy counter. In the narrowly focused ...

Washington Post

New York Times
Fri, 14 Jun 2013 20:10:29 -0700

Isabella Karle, who was also a chemist at the Naval Research Laboratory, joined her husband in the work, employing X-ray crystallography to determine the structure of previously intractable molecules. “After I found some structures that no one could ...
 
U.S. Naval Research Laboratory (press release)
Tue, 25 Jun 2013 13:45:15 -0700

Dr. Karle shared both his work and his life with his wife Dr. Isabella Karle, who worked alongside him at the Naval Research Laboratory. At NRL, Dr. Karle held the Chair of Science as Chief Scientist of the Laboratory for the Structure of Matter. Dr ...

Nature.com

Nature.com
Wed, 29 Jan 2014 10:02:15 -0800

Isabella Karle of the United States Naval Research Laboratory developed an experimental approach to using 'direct methods' of structural analysis for the solution of molecules smaller than 1,000 atoms. Her application of this statistically based ...

Scientist

Scientist
Mon, 17 Jun 2013 14:40:12 -0700

Jerome (left) and Isabella Karle cut their respective cakes as they retire from the Naval Research Laboratory after a combined 127 years of government service. WIKIMEDIA, US NAVY, JOHN F. WILLIAMSChemist Jerome Karle, who shared the 1985 Nobel ...
 
OregonLive.com (blog)
Sat, 22 Jun 2013 10:03:45 -0700

He, chemist wife Isabella Karle and mathematician Herbert Hauptman worked at the U.S. Naval Research Laboratory. Their breakthrough enabled advances in medicine, military research and other fields. He also participated in World War II's Manhattan ...
 
U.S. Naval Research Laboratory (press release)
Mon, 14 May 2012 04:12:14 -0700

She joined the Advanced Electrochemical Materials section as a staff scientist in 2010, under the direction of Dr. Debra Rolison, and was subsequently awarded the Jerome and Isabella Karle Fellowship to investigate three-dimensional architectures for ...
 
Laboratory Equipment
Tue, 18 Sep 2012 05:34:31 -0700

December 2, 1921- Isabella Karle. Isabella Karle is an American chemist who notable achievements include the development of her "Symbolic Addition Procedure," which has become the method of choice for structure determination from X-ray diffraction data ...
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