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For other uses, see In Vivo (disambiguation).

Studies that are in vivo (Latin for "within the living"; often not italicized in English[1][2][3]) are those in which the effects of various biological entities are tested on whole, living organisms usually animals including humans, and plants as opposed to a partial or dead organism, or those done in vitro ("within the glass"), i.e., in a laboratory environment using test tubes, petri dishes etc. Examples of investigations in vivo include: the pathogenesis of disease by comparing the effects of bacterial infection with the effects of purified bacterial toxins; the development of antibiotics, antiviral drugs, and new drugs generally; and new surgical procedures. Consequently Animal testing and clinical trials are major elements of in vivo research. In vivo testing is often employed over in vitro because it is better suited for observing the overall effects of an experiment on a living subject.

The English microbiologist Professor Harry Smith and his colleagues in the mid-1950s showed the importance of in vivo studies. They found that sterile filtrates of serum from animals infected with Bacillus anthracis were lethal for other animals, whereas extracts of culture fluid from the same organism grown in vitro were not. This discovery of anthrax toxin through the use of in vivo experiments had a major impact on studies of the pathogenesis of infectious disease.

The maxim in vivo veritas ("in a living thing [there is] truth")[4] is used to describe this type of testing and is a play on in vino veritas, ("in wine [there is] truth") a well-known proverb.

In vivo vs. ex vivo research[edit]

In microbiology in vivo is often used to refer to experimentation done in live isolated cells rather than in a whole organism, for example, cultured cells derived from biopsies. In this situation, the more specific term is ex vivo. Once cells are disrupted and individual parts are tested or analyzed, this is known as in vitro.

Methods of use[edit]

According to Christopher Lipinski and Andrew Hopkins, "Whether the aim is to discover drugs or to gain knowledge of biological systems, the nature and properties of a chemical tool cannot be considered independently of the system it is to be tested in. Compounds that bind to isolated recombinant proteins are one thing; chemical tools that can perturb cell function another; and pharmacological agents that can be tolerated by a live organism and perturb its systems are yet another. If it were simple to ascertain the properties required to develop a lead discovered in vitro to one that is active in vivo, drug discovery would be as reliable as drug manufacturing."[5]

See also[edit]

References[edit]

  1. ^ Merriam-Webster, Merriam-Webster's Collegiate Dictionary, Merriam-Webster. 
  2. ^ Iverson, Cheryl, et al. (eds) (2007). "12.1.1 Use of Italics". AMA Manual of Style (10th ed.). Oxford, Oxfordshire: Oxford University Press. ISBN 978-0-19-517633-9. 
  3. ^ American Psychological Association (2010), "4.21 Use of Italics", The Publication Manual of the American Psychological Association (6th ed.), Washington, DC, USA: APA, ISBN 978-1-4338-0562-2. 
  4. ^ Life Science Technologies, Cell Signaling: In Vivo Veritas, Science Magazine, 2007
  5. ^ Lipinski C, Hopkins A (2004). "Navigating chemical space for biology and medicine". Nature 432 (7019): 855–61. doi:10.1038/nature03193. PMID 15602551. 

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/In_vivo — Please support Wikipedia.
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The focus of this GEN Market & Tech analysis report is to discuss some of our data on in vitro transfection into cells in culture as well as present some in vivo transfection data (transfection into animal model systems). This report is an extension of ...
 
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Address correspondence to Eiji Itoi, MD, PhD, Department of Orthopedic Surgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. E-mail: itoi-eiji@med.tohoku.ac.jp ...
 
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Writing in Movement Disorders, the researchers say that their findings validate this imaging modality as an in vivo marker of nigrostriatal dopaminergic degeneration in patients with Parkinson's disease and related disorders. Walter Pirker (Medical ...

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Fri, 08 Aug 2014 14:41:11 -0700

Used directly on a patient's skin, it can accurately measure a melanoma tumor's depth and details in vivo. In the study, the researchers found that tumor cells produce more melanin than the healthy skin cells that surround them. The acoustic waves ...

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Mon, 01 Sep 2014 21:41:15 -0700

The Nigerian minister said the drug was considered as it has strong anti-viral property against Ebola virus in-vitro and in-vivo. 'These and the fact that it is considered safe, having passed through phases one and two clinical trails makes it good ...
 
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Tue, 02 Sep 2014 05:04:54 -0700

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He added that researchers are continuing to develop more effective and less toxic materials and plan to move toward in vivo studies in collaboration with UCSB. “Over the last year, there have been four undergraduate students involved in various ...
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