ISEA may refer to:
- Icosahedral Snyder Equal Area (grid)
- Independent Schools Education Association
- Institute for Social and Economic Analyses
- Institute for Social Entrepreneurship in Asia
- Inter-Society for the Electronic Arts (now ISEA International)
- International Safety Equipment Association, formerly the Industrial Safety Equipment Association
- International Society of Exposure Analysis (ISEA), now International Society of Exposure Science
- International Sports Engineering Association
- International Sustainable Energy Assessement, see Energy and Environmental Security Initiative
- Iowa State Education Association
- Island South-East Asia
- Rafael Isea, Venezuelan politician 1968-
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