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Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.[1][2]
Function [edit]
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[1]
References [edit]
Further reading [edit]
- Lam CY, Tam PO, Fan DS, et al. (2008). "A genome-wide scan maps a novel high myopia locus to 5p15". Invest. Ophthalmol. Vis. Sci. 49 (9): 3768–78. doi:10.1167/iovs.07-1126. PMID 18421076.
- Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests". European Journal of Human Genetics 18 (7): 815–20. doi:10.1038/ejhg.2010.2. PMC 2987367. PMID 20125193.
- Adamowicz M, Radlwimmer B, Rieker RJ, et al. (2006). "Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas". Genes Chromosomes Cancer 45 (9): 829–38. doi:10.1002/gcc.20343. PMID 16752383.
- Matsumoto K, Nishihara S, Kamimura M, et al. (2004). "The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation". Nat. Neurosci. 7 (6): 605–12. doi:10.1038/nn1249. PMID 15133517.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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(1) Basic domains
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Activating transcription factor ( AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 ( c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH ( 1, 2) · BATF · BLZF1 · C/EBP ( α, β, γ, δ, ε, ζ) · CREB ( 1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF ( B, F, G, K) · NFE ( 2, L1, L2, L3) · NFIL3 · NRL · NRF ( 1, 2, 3) · XBP1
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(1.2) Basic helix-loop-helix ( bHLH)
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ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLH ( 2, 9) · BMAL ( ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND ( 1, 2) · HES ( 5, 6) · HEY ( 1, 2, L) · HES1 · HIF ( 1A, 3A) · ID ( 1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors ( MyoD, Myogenin, MYF5, MYF6) · Neurogenins ( 1, 2, 3) · NeuroD ( 1, 2) · NPAS ( 1, 2, 3) · OLIG ( 1, 2) · Pho4 · Scleraxis · SIM ( 1, 2) · TAL ( 1, 2) · Twist · USF1
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(1.4) NF-1
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(1.5) RF-X
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(1.6) Basic helix-span-helix (bHSH)
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subfamily 1 ( Thyroid hormone ( α, β), CAR, FXR, LXR ( α, β), PPAR ( α, β/δ, γ), PXR, RAR ( α, β, γ), ROR ( α, β, γ), Rev-ErbA ( α, β), VDR)
subfamily 2 ( COUP-TF ( I, II), Ear-2, HNF4 ( α, γ), PNR, RXR ( α, β, γ), Testicular receptor ( 2, 4), TLX)
subfamily 3 ( Steroid hormone ( Androgen, Estrogen ( α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related ( α, β, γ))
subfamily 4 NUR ( NGFIB, NOR1, NURR1) · subfamily 5 ( LRH-1, SF1) · subfamily 6 ( GCNF) · subfamily 0 ( DAX1, SHP)
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(2.2) Other Cys4
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(2.3) Cys2His2
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General transcription factors ( TFIIA, TFIIB, TFIID, TFIIE ( 1, 2), TFIIF ( 1, 2), TFIIH ( 1, 2, 4, 2I, 3A, 3C1, 3C2))
ATBF1 · BCL ( 6, 11A, 11B) · CTCF · E4F1 · EGR ( 1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family ( 1, 2, 3, REST, S1, S2, YY1) · HIC ( 1, 2) · HIVEP ( 1, 2, 3) · IKZF ( 1, 2, 3) · ILF ( 2, 3) · KLF ( 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL ( 1, 2, 3, 4) · SP ( 1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 ( 7A, 7B) · ZBTB ( 11, 16, 17, 20, 32, 33, 40) · zinc finger ( 3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)
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(2.4) Cys6
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(2.5) Alternating composition
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ARX · CDX ( 1, 2) · CRX · CUTL1 · DBX ( 1, 2) · DLX ( 3, 4, 5) · EMX ( 1, 2) · EN ( 1, 2) · FHL ( 1, 2, 3) · HESX1 · HHEX · HLX · Homeobox ( A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX ( 1, 2, 3, 4, 5, 6, MKX) · LMX ( 1A, 1B) · MEIS ( 1, 2) · MEOX2 · MNX1 · MSX ( 1, 2) · NANOG · NKX ( 2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX ( 1, 2, 3) · PHF ( 1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX ( 2A, 2B) · PITX ( 1, 2, 3) · POU domain ( PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX ( 1, 2) · PDX1 · SATB2 · SHOX2 · SIX ( 1, 2, 3, 4, 5) · VAX1 · ZEB ( 1, 2)
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(3.2) Paired box
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E2F ( 1, 2, 3, 4, 5) · FOX proteins ( A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, I1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4)
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(3.5) Tryptophan clusters
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ELF ( 2, 4, 5) · EGF · ELK ( 1, 3, 4) · ERF · ETS ( 1, 2, ERG, SPIB) · ETV ( 1, 4, 5, 6) · FLI1 · Interferon regulatory factors ( 1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2
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(3.6) TEA domain
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transcriptional enhancer factor ( 1, 2, 3, 4)
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(4) β-Scaffold factors with minor groove contacts
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(4.3) p53
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BBX · HMGB ( 1, 2, 3, 4) · HMGN ( 1, 2, 3, 4) · HNF ( 1A, 1B) · LEF1 · SOX ( 1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF ( 3, 4) · TOX ( 1, 2, 3, 4)
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(4.9) Grainyhead
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(4.10) Cold-shock domain
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(4.11) Runt
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(0) Other transcription factors
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(0.2) HMGI(Y)
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(0.6) Miscellaneous
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ARID ( 1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI ( 16, 35) · MLL ( 2, 3, T1) · MNDA · NFY ( A, B, C) · Rho/ Sigma
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see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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 [RS] - TH P2P PCL (5-0) [FT CP+EOP, DV, C, IRx2] June 08 Watch in high quality! The Hatred P2P PCL, we go 5-0 undefeated!! Clans we fought : Corrupt pures + Eruption of pures Intense redemption Devastation Carnage ... |  [RuneScape] - TH P2P PCL, 6-0, FT. IRx2, CPx2, AAO, DV Th goes 6-0 at PCL, In P2P The Hatred P2P. |  Carnnage P2P PCL Ft: IRX2 & DVX2 CARNAGE PCL P2P ENDING 5-1 EPIC FIGHTS. |  [RS] - TH P2P PCL May 25, FT.[IRx2,DVI,Fo+Tggx2, Aao+Cy] TH fights 6 clans and goes 5-1 at PCL Runescape. |  BATTLEFIELD multiplayer hi leute. |  America - Sister Golden Hair - Live On "The Midnight Special" A live performance by the group America , on The Midnight Special. Please suport music like this . Purchase at retail outlets or online.... |  Playing in the Woods Playing in the woods again, good to get back on the bike after a couple of months of no riding, This is basically my first ride since the leaves fell from th... |  EBUIN TEMPPU | RP (Tilaaja spesiaali) Peli : Fertilize the egg Sain 50 tilaajaa täyteen ! Kiitos kaikille katsojille ! Mut ei se tähän lopu ! --- Muista antaa peukkua ylös ja lisää suosikkeihin j... |  [RS] - The Hatred F2P PCL May 24. FT DVI,IR,TGG We beat Ir and TGG Lost to DVI, was a close fight. |  Superstar Racing | Session #6 Gimme a like, it motivates me to make more Follow me on twitter - http://twitter.com/#!/rawrhyper Follow harry on twitter - http://twitter.com/#!/roastyharry... |
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