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Fluorine-18
Fluorine-18 decay.svg

Decay over 24 hours

General
Name, symbol Fluorine-18,18F
Neutrons 9
Protons 9
Nuclide data
Natural abundance Radioisotope
Half-life 109.771(20) min
Decay products 18O
Isotope mass 18.0009380(6) u
Spin 1+
Excess energy 873.431± 0.593 keV
Binding energy 137369.199± 0.593 keV
Decay mode Decay energy
Positron emission (97%) 0.6335 MeV
Electron capture (3%) 1.6555 MeV

Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18.

Fluorine-18 is an important isotope in the radiopharmaceutical industry, and is primarily synthesized into fluorodeoxyglucose (FDG) for use in positron emission tomography (PET scans). It is substituted for hydroxyl and used as a tracer in the scan. Its significance is due to both its short half-life and the emission of positrons when decaying. In the radiopharmaceutical industry, it is made using either a cyclotron or linear particle accelerator to bombard a target, usually of pure or enriched oxygen-18-water [1] with high energy protons (typically ~18 MeV protons).

Fluorine-18 is often substituted for a hydroxyl group in a radiotracer parent molecule, due to similar steric and electrostatic properties. This may however be problematic in certain applications due to possible changes in molecule polarity.

References[edit]

  1. ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.



Lighter:
fluorine-17
Fluorine-18 is an
isotope of fluorine
Heavier:
fluorine-19
Decay product of:
neon-18
Decay chain
of fluorine-18
Decays to:
oxygen-18

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Fluorine-18 — Please support Wikipedia.
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7189 videos foundNext > 

PET CT scan with new fluorine-18 tracer made more quickly using a palladium reagent

PET/CT scan using an 18F-labeled molecule made by palladium-18F complex. (c) Science/AAAS See Chemistry World story: http://bit.ly/t2xlvs.

Science Assessment - Radioisotopes: Fluorine18.m4v

Yr 10 Science Assessment Task - Radioisotopes: Fluorine18.

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7189 videos foundNext > 

5 news items

 
Medical Physics Web (subscription)
Thu, 24 Apr 2014 05:00:00 -0700

Filled with known activities of fluorine-18 FDG, six spheres were merged into the imaged lungs of the volunteers and a further six were incorporated into the liver. Synthetic PET lesions. "We create(d) a condition with all of the physiological ...

Medscape

Medscape
Thu, 17 Apr 2014 14:56:15 -0700

Functional brain imaging with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) may help determine whether a patient in a vegetative state has the potential to recover consciousness, according to a new study. "Our findings suggest ...
 
Lincoln Journal Star
Fri, 11 Apr 2014 10:25:42 -0700

Through his research at UNL, chemistry professor Stephen DiMagno developed a technique to attach the radioactive isotope fluorine-18 to different carrier molecules, according to a news release from UNL. The isotope enables a PET scanner to detect a ...
 
Wall Street Journal
Wed, 26 Mar 2014 04:26:15 -0700

NAV4694 is an investigational Fluorine-18 labeled beta-amyloid imaging agent currently being evaluated in late stage clinical trials for use as an aid in differential diagnosis and to monitor progression of Alzheimer's disease (AD), Mild Cognitive ...
 
Gaining Green
Mon, 07 Apr 2014 05:11:15 -0700

NAV4694 is an investigational Fluorine-18 labeled beta-amyloid imaging agent currently being evaluated in late stage clinical trials for use as an aid in differential diagnosis and to monitor progression of Alzheimer's disease (AD), Mild Cognitive ...
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