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Fluorine-18
Fluorine-18 decay.svg

Decay over 24 hours

General
Name, symbol Fluorine-18,18F
Neutrons 9
Protons 9
Nuclide data
Natural abundance Radioisotope
Half-life 109.771(20) min
Decay products 18O
Isotope mass 18.0009380(6) u
Spin 1+
Excess energy 873.431± 0.593 keV
Binding energy 137369.199± 0.593 keV
Decay mode Decay energy
Positron emission (97%) 0.6335 MeV
Electron capture (3%) 1.6555 MeV

Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18.

Fluorine-18 is an important isotope in the radiopharmaceutical industry, and is primarily synthesized into fluorodeoxyglucose (FDG) for use in positron emission tomography (PET scans). It is substituted for hydroxyl and used as a tracer in the scan. Its significance is due to both its short half-life and the emission of positrons when decaying. In the radiopharmaceutical industry, it is made using either a cyclotron or linear particle accelerator to bombard a target, usually of pure or enriched oxygen-18-water [1] with high energy protons (typically ~18 MeV protons).

Fluorine-18 is often substituted for a hydroxyl group in a radiotracer parent molecule, due to similar steric and electrostatic properties. This may however be problematic in certain applications due to possible changes in molecule polarity.

References[edit]

  1. ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.



Lighter:
fluorine-17
Fluorine-18 is an
isotope of fluorine
Heavier:
fluorine-19
Decay product of:
neon-18
Decay chain
of fluorine-18
Decays to:
oxygen-18

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Fluorine-18 — Please support Wikipedia.
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153 news items

 
Medscape
Thu, 21 May 2015 21:07:30 -0700

Background We assessed the clinical utility of β-amyloid (Aβ) imaging with 18F-florbetaben (FBB) in mild cognitive impairment (MCI) by evaluating its prognostic accuracy for progression to Alzheimer's disease (AD), comparing semiquantitative with ...
 
WhaTech
Thu, 28 May 2015 20:33:45 -0700

The PET radioisotopes market is dominated by fluorine-18 (F-18), followed by rubidium-82 (Rb-82) and poised to grow at a CAGR of more than 12% in the near future. Segments in the therapeutic market are beta emitters, brachytherapy isotopes, and alpha ...

OctaFinance.com

OctaFinance.com
Wed, 06 May 2015 06:40:41 -0700

... expressed on macrophages; NAV4694 is a Fluorine-18 (F-18) radiolabeled PET imaging agent being developed as an aid in the diagnosis of patients with signs or symptoms of Alzheimer's disease (AD) and mild cognitive impairment (MCI); among others.
 
UroToday
Wed, 08 Apr 2015 23:11:15 -0700

OBJECTIVE: Imaging with fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) has, until recently provided disappointing results with low sensitivity ranging from 31%-64% in patients with ...
 
Digital Journal
Mon, 04 May 2015 05:33:45 -0700

Flurpiridaz F 18 injection, a fluorine 18-labeled agent that binds to mitochondrial complex 1 (MC-1)[1], was designed to be a novel myocardial perfusion PET imaging agent that may better evaluate patients with known or suspected CAD, which is the most ...
 
Diagnostic Imaging
Fri, 25 Jun 2010 11:35:49 -0700

An intractable foe of what makes people what they are suddenly seems vulnerable, and it is imaging that has struck the blow. In a clinical trial at Johns Hopkins University, a PET agent built around fluorine-18 readily and safely distinguished the ...

io9

io9
Thu, 01 Jan 2015 11:09:45 -0800

One such material is fluorine-18. Fluorine-18 comprises nine protons and nine neutrons, but not for long; soon it slides down the periodic table of elements, one of its protons turning into a neutron via radioactive decay. The type of decay is called ...
 
Chemistry World
Tue, 24 Aug 2010 08:02:48 -0700

Making compounds that contain the useful radioisotope fluorine-18 (18F) could be much easier in future, say researchers in the UK and Finland. The team integrated the isotope into a popular fluorinating agent called Selectfluor, which opens up a wide ...
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