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Fluorine-18
Fluorine-18 decay.svg

Decay over 24 hours

General
Name, symbol Fluorine-18,18F
Neutrons 9
Protons 9
Nuclide data
Natural abundance Radioisotope
Half-life 109.771(20) min
Decay products 18O
Isotope mass 18.0009380(6) u
Spin 1+
Excess energy 873.431± 0.593 keV
Binding energy 137369.199± 0.593 keV
Decay mode Decay energy
Positron emission (97%) 0.6335 MeV
Electron capture (3%) 1.6555 MeV

Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18.

Fluorine-18 is an important isotope in the radiopharmaceutical industry, and is primarily synthesized into fluorodeoxyglucose (FDG) for use in positron emission tomography (PET scans). It is substituted for hydroxyl and used as a tracer in the scan. Its significance is due to both its short half-life and the emission of positrons when decaying. In the radiopharmaceutical industry, it is made using either a cyclotron or linear particle accelerator to bombard a target, usually of pure or enriched oxygen-18-water [1] with high energy protons (typically ~18 MeV protons).

Fluorine-18 is often substituted for a hydroxyl group in a radiotracer parent molecule, due to similar steric and electrostatic properties. This may however be problematic in certain applications due to possible changes in molecule polarity.

References[edit]

  1. ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.



Lighter:
fluorine-17
Fluorine-18 is an
isotope of fluorine
Heavier:
fluorine-19
Decay product of:
neon-18
Decay chain
of fluorine-18
Decays to:
oxygen-18

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Fluorine-18 — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.
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Fluorine 18

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168 news items

 
Phys.Org
Mon, 26 Jan 2015 05:30:00 -0800

A fused PET-CT image of the new phantom with its traceably calibrated amount of fluorine-18 (orange). The circular objects are the MR-visible test spheres; in this PET-CT image they appear as regions with no PET response. As cancer diagnostic tools, a ...
 
PR Newswire UK (press release)
Wed, 28 Jan 2015 09:15:00 -0800

Market is segmented by type of radioisotopes (Technetium-99m (TC-99m), Thallium-201 (TL-201), Iodine (I-123), Fluorine-18, Rubidium-82 (RB-82) and others). By application market is segmented into (cardiology, lymphoma, thyroid, neurology oncology, and ...

HCPLive

HCPLive
Tue, 27 Jan 2015 06:03:45 -0800

In an article in JAMA Neurology, Craig Curtis, MD and colleagues report on a multicenter PET imaging study on terminally ill dementia patients using flutemetamol injections tagged with radioactive fluorine 18. In cases where autopsy was later possible ...

io9

io9
Thu, 01 Jan 2015 11:09:45 -0800

One such material is fluorine-18. Fluorine-18 comprises nine protons and nine neutrons, but not for long; soon it slides down the periodic table of elements, one of its protons turning into a neutron via radioactive decay. The type of decay is called ...

Alzforum

Alzforum
Thu, 01 Jan 2015 14:08:40 -0800

GE180, a fluorine-18 ligand that binds a mitochondrial transporter protein and labels activated microglia in mouse brain, is being tested in healthy volunteers and in people with AD and relapsing/remitting multiple sclerosis (see Dec 2014 conference ...
 
Diagnostic Imaging
Fri, 25 Jun 2010 11:35:49 -0700

An intractable foe of what makes people what they are suddenly seems vulnerable, and it is imaging that has struck the blow. In a clinical trial at Johns Hopkins University, a PET agent built around fluorine-18 readily and safely distinguished the ...
 
Chemistry World
Tue, 24 Aug 2010 08:02:48 -0700

Making compounds that contain the useful radioisotope fluorine-18 (18F) could be much easier in future, say researchers in the UK and Finland. The team integrated the isotope into a popular fluorinating agent called Selectfluor, which opens up a wide ...
 
Chemistry World
Thu, 03 Nov 2011 11:56:15 -0700

A palladium-containing fluorination reagent can be used to quickly synthesise aromatic molecules labelled with fluorine-18, a positron emitter used in molecular imaging. The electrophilic reactions catalysed by the palladium compound allow fluorination ...
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