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Fluorine-18 decay.svg

Decay over 24 hours

Name, symbol Fluorine-18,18F
Neutrons 9
Protons 9
Nuclide data
Natural abundance Radioisotope
Half-life 109.771(20) min
Decay products 18O
Isotope mass 18.0009380(6) u
Spin 1+
Excess energy 873.431± 0.593 keV
Binding energy 137369.199± 0.593 keV
Decay mode Decay energy
Positron emission (97%) 0.6335 MeV
Electron capture (3%) 1.6555 MeV

Fluorine is an univalent poisonous gaseous halogen, it is pale yellow-green and it is the most chemically reactive and electronegative of all the elements. Fluorine readily forms compounds with most other elements, even with the noble gases krypton, xenon and radon. It is so reactive that glass, metals, and even water, as well as other substances, burn with a bright flame in a jet of fluorine gas. In aqueous solution, fluorine commonly occurs as the fluoride ion F-. Fluorides are compounds that combine fluoride with some positively charged counterpart.


Atomic fluorine and molecular fluorine are used for plasma etching in semiconductor manufacturing, flat panel display production and MEMs fabrication. Fluorine is indirectly used in the production of low friction plastics such as teflon and in halons such as freon, in the production of uranium. Fluorochlorohydrocarbons are used extensively in air conditioning and in refrigeration. Fluorides are often added to toothpaste and, somewhat controversially, to municipal water supplies to prevent dental cavities.

Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18.

Fluorine-18 is an important isotope in the radiopharmaceutical industry, and is primarily synthesized into fluorodeoxyglucose (FDG) for use in positron emission tomography (PET scans). It is substituted for hydroxyl and used as a tracer in the scan. Its significance is due to both its short half-life and the emission of positrons when decaying. In the radiopharmaceutical industry, it is made using either a cyclotron or linear particle accelerator to bombard a target, usually of pure or enriched oxygen-18-water [1] with high energy protons (typically ~18 MeV protons). Fluorine also has many uses in Daltons theory of atoms.

Fluorine-18 is often substituted for a hydroxyl group in a radiotracer parent molecule, due to similar steric and electrostatic properties. This may however be problematic in certain applications due to possible changes in molecule polarity.


  1. ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.

Fluorine-18 is an
isotope of fluorine
Decay product of:
Decay chain
of fluorine-18
Decays to:

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Fluorine-18 — Please support Wikipedia.
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173 news items

Dakota Financial News
Wed, 25 Nov 2015 17:07:30 -0800

NAV4694 is a fluorine-18 radiolabeled PET imaging agent being developed as an aid in the diagnosis of patients with signs or symptoms of Alzheimer's disease (AD) and mild cognitive impairment. NAV5001 is an iodine-123 radiolabeled SPECT imaging ...

Business Wire (press release)

Business Wire (press release)
Sun, 08 Nov 2015 06:03:45 -0800

Flurpiridaz F 18 injection, a fluorine 18-labeled agent that binds to mitochondrial complex 1 (MC-1)1, was designed to be a novel myocardial perfusion positron emission tomography imaging agent that may better evaluate patients with known or suspected ...

Cancer Network

Cancer Network
Sun, 15 Nov 2015 16:11:15 -0800

Fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET)/CT can provide further information to help guide management of vulvar cancer. Many of the studies assessing the usefulness of a PET scan are small retrospective studies.

General Surgery News

General Surgery News
Mon, 16 Nov 2015 14:30:00 -0800

11 Fluorodeoxyglucose–positron emission tomography (FDG-PET), which looks at the fluorine-18 fluorodeoxyglucose metabolic uptake of tissue, may have promise in identifying metastatic disease, especially when FDG-PET scanning is combined with CT ...


Fri, 30 Oct 2015 06:30:00 -0700

This, together with the advantage of a longer half-life of the positron emitter fluorine-18 radio isotope, makes [18F]DPA-714 highly attractive for in vivo imaging of microglia activation in animal models as well as for future clinical application. Up ...

Deccan Herald

Deccan Herald
Mon, 16 Nov 2015 10:00:00 -0800

A more recent development in nuclear medicine is the Positron Emission Tomography (PET), whose important clinical role is in oncology, with fluorine-18 as the tracer. It is proven to be the most accurate non-invasive method of detecting and evaluating ...

Oncology Nurse Advisor

Oncology Nurse Advisor
Tue, 03 Nov 2015 10:57:09 -0800

Of the 58 patients with adequate follow-up, 20.7 percent had fluorine 18 fluorodeoxyglucose-avid IMLN, with a median standardized uptake value of 2.30; only one of these was malignant (PPV, 0.083). "IMLNs identified at implant-protocol breast MRI after ...
Medgadget.com (blog)
Mon, 09 Nov 2015 22:28:06 -0800

Radiopharmaceuticals such as nitrogen-13, rubidium-82, fluorine-18, oxygen-15 and other radioisotopes are used in the nuclear imaging process. PACS is an emerging and promising technology in nuclear imaging sector with its potential benefits over other ...

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