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Fluorine-18
Fluorine-18 decay.svg

Decay over 24 hours

General
Name, symbol Fluorine-18,18F
Neutrons 9
Protons 9
Nuclide data
Natural abundance Radioisotope
Half-life 109.771(20) min
Decay products 18O
Isotope mass 18.0009380(6) u
Spin 1+
Excess energy 873.431± 0.593 keV
Binding energy 137369.199± 0.593 keV
Decay mode Decay energy
Positron emission (97%) 0.6335 MeV
Electron capture (3%) 1.6555 MeV

Fluorine is an univalent poisonous gaseous halogen, it is pale yellow-green and it is the most chemically reactive and electronegative of all the elements. Fluorine readily forms compounds with most other elements, even with the noble gases krypton, xenon and radon. It is so reactive that glass, metals, and even water, as well as other substances, burn with a bright flame in a jet of fluorine gas. In aqueous solution, fluorine commonly occurs as the fluoride ion F-. Fluorides are compounds that combine fluoride with some positively charged counterpart.

Applications[edit]

Atomic fluorine and molecular fluorine are used for plasma etching in semiconductor manufacturing, flat panel display production and MEMs fabrication. Fluorine is indirectly used in the production of low friction plastics such as teflon and in halons such as freon, in the production of uranium. Fluorochlorohydrocarbons are used extensively in air conditioning and in refrigeration. Fluorides are often added to toothpaste and, somewhat controversially, to municipal water supplies to prevent dental cavities.

Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18.

Fluorine-18 is an important isotope in the radiopharmaceutical industry, and is primarily synthesized into fluorodeoxyglucose (FDG) for use in positron emission tomography (PET scans). It is substituted for hydroxyl and used as a tracer in the scan. Its significance is due to both its short half-life and the emission of positrons when decaying. In the radiopharmaceutical industry, it is made using either a cyclotron or linear particle accelerator to bombard a target, usually of pure or enriched oxygen-18-water [1] with high energy protons (typically ~18 MeV protons). Fluorine also has many uses in Daltons theory of atoms.

Fluorine-18 is often substituted for a hydroxyl group in a radiotracer parent molecule, due to similar steric and electrostatic properties. This may however be problematic in certain applications due to possible changes in molecule polarity.

References[edit]

  1. ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.



Lighter:
fluorine-17
Fluorine-18 is an
isotope of fluorine
Heavier:
fluorine-19
Decay product of:
neon-18
Decay chain
of fluorine-18
Decays to:
oxygen-18

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Fluorine-18 — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.

179 news items

OctaFinance.com

Inside Trade
Fri, 04 Sep 2015 06:07:30 -0700

Its development programs include NAV4694, an Fluorine-18 radiolabeled positron emission tomography imaging agent, which is used as an aid in the diagnosis of patients with signs or symptoms of Alzheimer's disease and mild cognitive impairment; and ...
 
Dakota Financial News
Mon, 31 Aug 2015 06:41:15 -0700

NAV4694 is a fluorine-18 radiolabeled PET imaging agent being developed as an aid in the diagnosis of patients with signs or symptoms of Alzheimer's disease (AD) and mild cognitive impairment. NAV5001 is an iodine-123 radiolabeled SPECT imaging ...

Medgadget.com (blog)

Medgadget.com (blog)
Mon, 31 Aug 2015 13:15:00 -0700

Radiopharmaceuticals such as nitrogen-13, rubidium-82, fluorine-18, oxygen-15 and other radioisotopes are used in the nuclear imaging process. PACS is an emerging and promising technology in nuclear imaging sector with its potential benefits over other ...
 
Dakota Financial News
Tue, 11 Aug 2015 15:30:00 -0700

... evaluate patients with breast cancer and melanoma; Navidea's Manocept platform is predicated on the ability to specifically target the CD206 mannose receptor expressed on macrophages; NAV4694 is a Fluorine-18 (F-18) radiolabeled PET imaging agent ...
 
The Legacy
Sat, 15 Aug 2015 11:45:00 -0700

NAV4694 is a fluorine-18 radiolabeled PET imaging agent being developed as an aid in the diagnosis of patients with signs or symptoms of Alzheimer's disease (AD) and mild cognitive impairment. NAV5001 is an iodine-123 radiolabeled SPECT imaging ...
 
WKRB News
Thu, 13 Aug 2015 15:03:51 -0700

NAV4694 is a fluorine-18 radiolabeled PET imaging agent being developed as an aid in the diagnosis of patients with signs or symptoms of Alzheimer's disease (AD) and mild cognitive impairment. NAV5001 is an iodine-123 radiolabeled SPECT imaging ...
 
Baystreet.ca
Thu, 13 Aug 2015 09:18:45 -0700

According to the American Heart Association, an American dies from cardiovascular disease every 39 seconds and more than 83 million Americans have at least one condition affecting the heart or blood vessels. Innovative medicines have helped reduce ...

The Nation Newspaper

The Nation Newspaper
Wed, 12 Aug 2015 17:11:15 -0700

Thus, cyclotron products such as fluorine-18 (18F), carbon-11 (11C) and iodine-123 (123I) (with half-lives of 110 min, 20 min and 13 h, respectively) will not be available in these countries except at enormous cost to patients by ordering additional ...
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