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Fluorine-18
Fluorine-18 decay.svg

Decay over 24 hours

General
Name, symbol Fluorine-18,18F
Neutrons 9
Protons 9
Nuclide data
Natural abundance Radioisotope
Half-life 109.771(20) min
Decay products 18O
Isotope mass 18.0009380(6) u
Spin 1+
Excess energy 873.431± 0.593 keV
Binding energy 137369.199± 0.593 keV
Decay mode Decay energy
Positron emission (97%) 0.6335 MeV
Electron capture (3%) 1.6555 MeV

Fluorine is an univalent poisonous gaseous halogen, it is pale yellow-green and it is the most chemically reactive and electronegative of all the elements. Fluorine readily forms compounds with most other elements, even with the noble gases krypton, xenon and radon. It is so reactive that glass, metals, and even water, as well as other substances, burn with a bright flame in a jet of fluorine gas. In aqueous solution, fluorine commonly occurs as the fluoride ion F-. Fluorides are compounds that combine fluoride with some positively charged counterpart.

Applications[edit]

Atomic fluorine and molecular fluorine are used for plasma etching in semiconductor manufacturing, flat panel display production and MEMs fabrication. Fluorine is indirectly used in the production of low friction plastics such as teflon and in halons such as freon, in the production of uranium. Fluorochlorohydrocarbons are used extensively in air conditioning and in refrigeration. Fluorides are often added to toothpaste and, somewhat controversially, to municipal water supplies to prevent dental cavities.

Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18.

Fluorine-18 is an important isotope in the radiopharmaceutical industry, and is primarily synthesized into fluorodeoxyglucose (FDG) for use in positron emission tomography (PET scans). It is substituted for hydroxyl and used as a tracer in the scan. Its significance is due to both its short half-life and the emission of positrons when decaying. In the radiopharmaceutical industry, it is made using either a cyclotron or linear particle accelerator to bombard a target, usually of pure or enriched oxygen-18-water [1] with high energy protons (typically ~18 MeV protons).

Fluorine-18 is often substituted for a hydroxyl group in a radiotracer parent molecule, due to similar steric and electrostatic properties. This may however be problematic in certain applications due to possible changes in molecule polarity.

References[edit]

  1. ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.



Lighter:
fluorine-17
Fluorine-18 is an
isotope of fluorine
Heavier:
fluorine-19
Decay product of:
neon-18
Decay chain
of fluorine-18
Decays to:
oxygen-18

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Fluorine-18 — Please support Wikipedia.
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Fluorine 18

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173 news items

 
sleekmoney
Mon, 06 Jul 2015 07:15:00 -0700

... expressed on macrophages; NAV4694 is a Fluorine-18 (F-18) radiolabeled PET imaging agent being developed as an aid in the diagnosis of patients with signs or symptoms of Alzheimer's disease (AD) and mild cognitive impairment (MCI); among others.

Net Newsledger

Net Newsledger
Mon, 06 Jul 2015 02:00:00 -0700

The Elixys platform, developed by SOFIE Biosciences (co-founder Michael Phelps helped develop PET), mixes standardized reagents with the isotope fluorine-18 (18F) using a protocol or “recipe” shared among several sites in North America. The 18F isotope ...

Mirror.co.uk

Medscape
Mon, 15 Jun 2015 04:52:15 -0700

UPDATED June 17, 2015 // Physicians should be aware that tattoo ink can look like the spread of cancer to the lymph nodes on diagnostic imaging — and unnecessary treatment can result. That is the take-home message from a case report of a 32-year-old ...
 
Dakota Financial News
Thu, 02 Jul 2015 16:48:45 -0700

... evaluate patients with breast cancer and melanoma; Navidea's Manocept platform is predicated on the ability to specifically target the CD206 mannose receptor expressed on macrophages; NAV4694 is a Fluorine-18 (F-18) radiolabeled PET imaging agent ...
 
The Legacy
Sat, 04 Jul 2015 06:41:15 -0700

... expressed on macrophages; NAV4694 is a Fluorine-18 (F-18) radiolabeled PET imaging agent being developed as an aid in the diagnosis of patients with signs or symptoms of Alzheimer's disease (AD) and mild cognitive impairment (MCI); among others.
 
PR Newswire (press release)
Thu, 25 Jun 2015 21:52:30 -0700

The Global Nuclear Medicine Diagnostics Market report consists of a detailed account of the Market dynamics- drivers, restraints, opportunities and threats. It is segmented by Diagnostic technologies and applications. It also gives a detailed account ...
 
WKRB News
Thu, 02 Jul 2015 16:48:45 -0700

... evaluate patients with breast cancer and melanoma; Navidea's Manocept platform is predicated on the ability to specifically target the CD206 mannose receptor expressed on macrophages; NAV4694 is a Fluorine-18 (F-18) radiolabeled PET imaging agent ...
 
The Legacy
Fri, 26 Jun 2015 16:03:45 -0700

... evaluate patients with breast cancer and melanoma; Navidea's Manocept platform is predicated on the ability to specifically target the CD206 mannose receptor expressed on macrophages; NAV4694 is a Fluorine-18 (F-18) radiolabeled PET imaging agent ...
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