digplanet beta 1: Athena
Share digplanet:

Agriculture

Applied sciences

Arts

Belief

Business

Chronology

Culture

Education

Environment

Geography

Health

History

Humanities

Language

Law

Life

Mathematics

Nature

People

Politics

Science

Society

Technology

Fluorine-18
Fluorine-18 decay.svg

Decay over 24 hours

General
Name, symbol Fluorine-18,18F
Neutrons 9
Protons 9
Nuclide data
Natural abundance Radioisotope
Half-life 109.771(20) min
Decay products 18O
Isotope mass 18.0009380(6) u
Spin 1+
Excess energy 873.431± 0.593 keV
Binding energy 137369.199± 0.593 keV
Decay mode Decay energy
Positron emission (97%) 0.6335 MeV
Electron capture (3%) 1.6555 MeV

Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18.

Fluorine-18 is an important isotope in the radiopharmaceutical industry, and is primarily synthesized into fluorodeoxyglucose (FDG) for use in positron emission tomography (PET scans). It is substituted for hydroxyl and used as a tracer in the scan. Its significance is due to both its short half-life and the emission of positrons when decaying. In the radiopharmaceutical industry, it is made using either a cyclotron or linear particle accelerator to bombard a target, usually of pure or enriched oxygen-18-water [1] with high energy protons (typically ~18 MeV protons).

Fluorine-18 is often substituted for a hydroxyl group in a radiotracer parent molecule, due to similar steric and electrostatic properties. This may however be problematic in certain applications due to possible changes in molecule polarity.

References[edit]

  1. ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.



Lighter:
fluorine-17
Fluorine-18 is an
isotope of fluorine
Heavier:
fluorine-19
Decay product of:
neon-18
Decay chain
of fluorine-18
Decays to:
oxygen-18

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Fluorine-18 — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.

132 news items

OctaFinance.com

OctaFinance.com
Fri, 03 Apr 2015 16:49:15 -0700

... to specifically target the CD206 mannose receptor expressed on macrophages; NAV4694 is a Fluorine-18 (F-18) radiolabeled PET imaging agent being developed as an aid in the diagnosis of patients with signs or symptoms of Alzheimer�s disease (AD) ...
 
Family Practice News Digital Network
Mon, 30 Mar 2015 21:12:42 -0700

Cerebrospinal fluid levels of amyloid-beta1-42 and brain amyloid-beta PET imaging with florbetapir-fluorine-18 had a limited association with each other as biomarkers for Alzheimer's disease in a cross-sectional analysis of scans and CSF samples taken ...
 
Diagnostic Imaging
Fri, 25 Jun 2010 11:35:49 -0700

An intractable foe of what makes people what they are suddenly seems vulnerable, and it is imaging that has struck the blow. In a clinical trial at Johns Hopkins University, a PET agent built around fluorine-18 readily and safely distinguished the ...

io9

io9
Thu, 01 Jan 2015 11:09:45 -0800

One such material is fluorine-18. Fluorine-18 comprises nine protons and nine neutrons, but not for long; soon it slides down the periodic table of elements, one of its protons turning into a neutron via radioactive decay. The type of decay is called ...
 
Chemistry World
Thu, 03 Nov 2011 11:56:15 -0700

A palladium-containing fluorination reagent can be used to quickly synthesise aromatic molecules labelled with fluorine-18, a positron emitter used in molecular imaging. The electrophilic reactions catalysed by the palladium compound allow fluorination ...
 
Chemistry World
Tue, 24 Aug 2010 08:02:48 -0700

Making compounds that contain the useful radioisotope fluorine-18 (18F) could be much easier in future, say researchers in the UK and Finland. The team integrated the isotope into a popular fluorinating agent called Selectfluor, which opens up a wide ...

Alzforum

Alzforum
Wed, 10 Dec 2014 12:21:43 -0800

It sports fluorine-18, which has a longer half-life than C-11 and need not be synthesized on site. Earlier this year, researchers reported that GE180 has a better signal-to-noise ratio than PK11195 when picking up glial activation in a mouse model of ...

The Chronicle Journal

The Chronicle Journal
Tue, 10 Feb 2015 21:37:30 -0800

The major isotope used at Regional will be fluorine-18. The cyclotron will also produce Technetium-99m, the isotope that was in such short supply a few years ago during shutdowns at the Chalk River nuclear reactor near Ottawa. The advantage of having a ...
Loading

Oops, we seem to be having trouble contacting Twitter

Support Wikipedia

A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia. Please add your support for Wikipedia!

Searchlight Group

Digplanet also receives support from Searchlight Group. Visit Searchlight