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Fluorine-18 decay.svg

Decay over 24 hours

Name, symbol Fluorine-18,18F
Neutrons 9
Protons 9
Nuclide data
Natural abundance Radioisotope
Half-life 109.771(20) min
Decay products 18O
Isotope mass 18.0009380(6) u
Spin 1+
Excess energy 873.431± 0.593 keV
Binding energy 137369.199± 0.593 keV
Decay mode Decay energy
Positron emission (97%) 0.6335 MeV
Electron capture (3%) 1.6555 MeV

Fluorine-18 (18F) is a fluorine radioisotope which is an important source of positrons. It has a mass of 18.0009380(6) u and its half-life is 109.771(20) minutes. It decays by positron emission 97% of the time and electron capture 3% of the time. Both modes of decay yield stable oxygen-18.

Fluorine-18 is an important isotope in the radiopharmaceutical industry, and is primarily synthesized into fluorodeoxyglucose (FDG) for use in positron emission tomography (PET scans). It is substituted for hydroxyl and used as a tracer in the scan. Its significance is due to both its short half-life and the emission of positrons when decaying. In the radiopharmaceutical industry, it is made using either a cyclotron or linear particle accelerator to bombard a target, usually of pure or enriched oxygen-18-water [1] with high energy protons (typically ~18 MeV protons).

Fluorine-18 is often substituted for a hydroxyl group in a radiotracer parent molecule, due to similar steric and electrostatic properties. This may however be problematic in certain applications due to possible changes in molecule polarity.


  1. ^ Fowler J. S. and Wolf A. P. (1982) The synthesis of carbon-11, fluorine-18 and nitrogen-13 labeled radiotracers for biomedical applications. Nucl. Sci. Ser. Natl Acad. Sci. Natl Res. Council Monogr. 1982.

Fluorine-18 is an
isotope of fluorine
Decay product of:
Decay chain
of fluorine-18
Decays to:

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7 news items

Vision Systems Design
Thu, 18 Sep 2014 04:26:15 -0700

Flurpiridaz F 18 injection, a fluorine 18-labeled agent that binds to mitochondrial complex 1 (MC-1)[1], was designed to be a novel myocardial perfusion PET imaging agent that may better evaluate patients with known or suspected coronary artery disease ...

European Hospital

European Hospital
Sun, 31 Aug 2014 12:30:00 -0700

Korosoglou points out: 'Fluorine-18 positron emission tomography combined with computed tomography, known as PET/CT, might become clinically relevant.' Fluorine-18 is a radiotracer that was previously used to visualise bone formation. Recent clinical ...

Medical Xpress

Medical Xpress
Thu, 04 Sep 2014 05:11:15 -0700

Prostate cancer is the most common type of cancer in men, with more than 4000 cases diagnosed in Norway every year. The photo shows researcher Live Eikenes from NTNU and radiographer Per Arvid Steen from St. Olavs Hospital with the PET MRI …more.


Tue, 02 Sep 2014 04:26:23 -0700

Martin de Kort, Scientific Project Manager, EATRIS, told Outsourcing-Pharma.com that because monoclonal antibodies are long-lived, Zirconium-89 makes for a better radioisotope than shorter-acting tracers like Fluorine-18. “Zirconium-labelled antibodies ...
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Enzymes perform a range of key functions for the human body. As such, inside our cells, and inside the tiniest of organelles, proteins called cathepsins assist healthy cells with protein breakdown. 3D model of a fluorine-18-labelled azadipeptide ...
Mon, 01 Sep 2014 04:15:00 -0700

Enzyme erfüllen im menschlichen Körper viele wichtige Aufgaben. Im Inneren von kleinsten Zellorganellen hilft die Gruppe der Cathepsine beispielsweise gesunden Zellen beim Abbau von Eiweißstoffen. Zum Problem werden diese Enzyme hingegen, wenn ...
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Tue, 26 Aug 2014 02:56:15 -0700

La radioactividad que permanece después de diez reducciones a la mitad es cercana a una milésima de su capacidad radioactiva original. La “vida-media” del Iodine-131 es de 8 días. Fluorine-18, 110 minutos. Cobalto-60, 5,271 años. Esto se conoce como ...

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