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Fedotozine

Systematic (IUPAC) name
(2R)-N,N-dimethyl-2-phenyl-1-[(3,4,5-trimethoxybenzyl)oxy]-2-butanamine
Clinical data
Pregnancy cat.	?
Legal status	Non-regulated
Routes	Oral
Identifiers
CAS number	123618-00-8 133267-27-3 (tartrate)
ATC code	None
PubChem	CID 6918160
ChemSpider	5293373
Chemical data
Formula	C₂₂H₃₁N O₄
Mol. mass	373.486 g/mol
SMILES O(c1cc(cc(OC)c1OC)COC[C@@](c2ccccc2)(N(C)C)CC)C
InChI InChI=1S/C22H31NO4/c1-7-22(23(2)3,18-11-9-8-10-12-18)16-27-15-17-13-19(24-4)21(26-6)20(14-17)25-5/h8-14H,7,15-16H2,1-6H3/t22-/m0/s1 Key:MVKIWCDXKCUDEH-QFIPXVFZSA-N

Fedotozine (INN; Jo-1196) is an opioid drug of the arylacetamide series which acts as a peripherally-specific, selective κ₁-opioid receptor agonist with preference for the κ_1A subtype.^[1] It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials,^[1]^[2]^[3] but ultimately development was discontinued and it was never marketed.

References [edit]

^ ^a ^b Delvaux M (January 2001). "Pharmacology and clinical experience with fedotozine". Expert Opinion on Investigational Drugs 10 (1): 97–110. doi:10.1517/13543784.10.1.97. PMID 11116283.
^ Barber A, Gottschlich R (October 1997). "Novel developments with selective, non-peptidic kappa-opioid receptor agonists". Expert Opinion on Investigational Drugs 6 (10): 1351–68. doi:10.1517/13543784.6.10.1351. PMID 15989506.
^ Lembo A (2006). "Peripheral opioids for functional GI disease: a reappraisal". Digestive Diseases (Basel, Switzerland) 24 (1-2): 91–8. doi:10.1159/000090312. PMID 16699267.

Drugs for functional gastrointestinal disorders (A03)

Drugs for
functional bowel disorders

Antimuscarinics

Tertiary amino group	Oxyphencyclimine Camylofin Mebeverine Trimebutine Rociverine Dicycloverine Dihexyverine Difemerine Piperidolate

Quaternary ammonium compounds	Benzilone Mepenzolate Pipenzolate Glycopyrronium Oxyphenonium Penthienate Methantheline Propantheline Otilonium Tridihexethyl Isopropamide Hexocyclium Poldine Bevonium Diphemanil Tiemonium Prifinium Timepidium Fenpiverinium

Phosphodiesterase inhibitors

Acting on serotonin receptors

5-HT₃ antagonists
- Alosetron
- Cilansetron
5-HT₄ agonists

Other

Belladonna and derivatives
(antimuscarinics)

tertiary amines: Atropine
Hyoscyamine

Propulsives

M: DIG

anat (t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug (A2A/2B/3/4/5/6/7/14/16), blte

Opioids

Opium and
poppy straw
derivatives

Crude opiate
extracts /
whole opium
products

Natural opiates

Opium alkaloids	Codeine Morphine Oripavine Pseudomorphine Thebaine

Alkaloid salts mixtures	Pantopon Papaveretum (Omnopon)

Semisynthetics
including
Bentley
compounds

Morphine family	2,4-Dinitrophenylmorphine 6-MDDM Azidomorphine Chlornaltrexamine Desocodeine Desomorphine Dihydromorphine Hydromorphinol Methyldesorphine N-Phenethylnormorphine RAM-378

3,6-diesters of morphine	Acetylpropionylmorphine Acetylmorphinol (Dihydroheroin) Dibenzoylmorphine Dipropanoylmorphine Heroin (Diacetylmorphine) Nicomorphine

Codeine-dionine family	6-Monoacetylcodeine Benzylmorphine Codeine methylbromide Ethylmorphine (Dionine) Isocodeine Heterocodeine Pholcodine Myrophine

Morphinones and morphols	14-Cinnamoyloxycodeinone 14-Ethoxymetopon 14-Methoxymetopon 14-Phenylpropoxymetopon 3-Acetyloxymorphone 3,14-Diacetyloxymorphone Methyldihydromorphine 6-MDDM 7-Spiroindanyloxymorphone Acetylmorphone Codeinone Codorphone Codoxime IBNtxA Thebacon Hydrocodone Hydromorphone Metopon Morphinone N-Phenethyl-14-ethoxymetopon Nalmexone Oxycodone Oxymorphol Oxymorphone Pentamorphone Semorphone

Morphides	Chloromorphide α-Chlorocodide

Dihydrocodeine series	14-Hydroxydihydrocodeine Acetyldihydrocodeine Dihydrocodeine Nicocodeine Nicodicodeine

Nitrogen morphine derivatives	Codeine-N-oxide Morphine-N-oxide

Hydrazones	Oxymorphazone

Halogenated morphine derivatives	1-Iodomorphine

Active opiate
metabolites

Morphinans

Benzomorphans

4-Phenylpiperidines

Pethidines (Meperidines)	4-Fluoromeperidine Allylnorpethidine Anileridine Benzethidine Carperidine Difenoxin Diphenoxylate Etoxeridine (Carbetidine) Furethidine Hydroxypethidine (Bemidone) Morpheridine Oxpheneridine (Carbamethidine) Pethidine (Meperidine) Pethidine Intermediate A Pethidine Intermediate B (Norpethidine) Pethidine Intermediate C (Pethidinic Acid) Pheneridine Phenoperidine Piminodine Properidine (Ipropethidine) Sameridine

Prodines	Allylprodine Meprodine (α-meprodine / β-meprodine) MPPP (Desmethylprodine) PEPAP Prodine (α-prodine / β-prodine) Prosidol Trimeperidine (Promedol)

Ketobemidones	Acetoxyketobemidone Droxypropine Ketobemidone Methylketobemidone Propylketobemidone

Others	Alvimopan Loperamide Picenadol

Open chain
opioids

Amidones	Dipipanone Isomethadone Levomethadone Methadone Normethadone Norpipanone Phenadoxone (Heptazone)

Methadols	Acetylmethadol Alphacetylmethadol Alphamethadol Betacetylmethadol Betamethadol Dimepheptanol (methadol) Isomethadol Levacetylmethadol Noracymethadol

Moramides	Desmethylmoramide Dextromoramide Levomoramide Moramide/Racemoramide

Thiambutenes	Diethylthiambutene Dimethylthiambutene Ethylmethylthiambutene Piperidylthiambutene Pyrrolidinylthiambutene Thiambutene Tipepidine

Phenalkoxams	Dextropropoxyphene Dimenoxadol Dioxaphetyl butyrate Levopropoxyphene Norpropoxyphene

Ampromides	Diampromide Phenampromide Propiram

Others	Alimadol IC-26 Isoaminile Lefetamine R-4066

Anilidopiperidines

Oripavine
derivatives

Phenazepanes

Pirinitramides

Benzimidazoles

Indoles

Diphenylmethyl-
piperazines

Opioid peptides

Others

Opioid
antagonists &
inverse agonists

Uncategorized
opioids

List of opioids

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Fedotozine

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