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	MacroGenics Presents Phase 1 Data at ASCO Showing Signs of Clinical Benefit ... PR Newswire (press release) Mon, 03 Jun 2013 16:14:38 -0700 MacroGenics has optimized the Fc region of margetuximab with the goal of increasing cancer cell killing with Antibody-Dependent Cell-mediated Cytotoxicity (ADCC). During the study, ADCC was measured ex-vivo in peripheral blood mononuclear cells ...
	MacroGenics Announces Margetuximab (MGAH22) Phase 1 Data Presentation ... PipelineReview.com (press release) Tue, 21 May 2013 09:53:02 -0700 MacroGenics has optimized the Fc region of margetuximab to increase cancer cell killing via Antibody-Dependent Cell-mediated Cytotoxicity (ADCC). Margetuximab also has shown improved control of tumor growth in human tumor xenograft models in mice ...
	Momenta Pharmaceuticals Management Presents at 2013 UBS Global ... Seeking Alpha Wed, 22 May 2013 11:12:46 -0700 Now with this technology, we can either sialylate a plasma based IVIG product or more broadly, we could use this technology across a number of different antibodies and this would be focused on the Fc region of the antibody, sialylating that would again ...
	U.S. Patents Awarded to Inventors in Maryland (May 24) Targeted News Service (subscription) Fri, 24 May 2013 11:44:55 -0700 The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein ...
	U.S. Patents Awarded to Inventors in Arizona (May 25) Targeted News Service (subscription) Sat, 25 May 2013 11:44:04 -0700 The remaining reactive functional groups may be conjugated directly to a specific binding molecule, such as to the oxidized carbohydrate of the Fc region of the antibody. Disclosed conjugates display large signal amplification as compared to those ...

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