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ETH-LAD
ETH-LAD structure.png
Systematic (IUPAC) name
(6aR,9R)-N,N-diethyl-7-ethyl-4,6,6a,7,8,9-
hexahydroindolo-[4,3-fg]quinoline-9-carboxamide
Clinical data
Legal status
  • UK: Controlled as an "N-alkyl derivative of lysergamide"
  • US: Uncontrolled but potentially an analog of LSD under the Federal Analog Act
Routes Oral
Pharmacokinetic data
Metabolism hepatic
Excretion renal
Identifiers
CAS number 65527-62-0 YesY
ATC code ?
PubChem CID 44457783
ChemSpider 21106300 YesY
ChEMBL CHEMBL22694 YesY
Synonyms ETH-LAD, 6-ethyl-6-nor-Lysergic acid diethylamide
Chemical data
Formula C21H27N3O 
Mol. mass 337.47 g/mol
 YesY (what is this?)  (verify)

ETH-LAD, 6-ethyl-6-nor-lysergic acid diethylamide is an analogue of LSD. It is described by Alexander Shulgin in the book TiHKAL. ETH-LAD is a psychedelic drug similar to LSD, and is slightly more potent than LSD itself,[1] with an active dose reported at between 40 and 150 micrograms. ETH-LAD has subtly different effects to LSD, described as less demanding.

Legality[edit]

On June 10th 2014 the UK Advisory Council on the Misuse of Drugs (ACMD) recommended that LSZ be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use.[2] The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part of The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014.

Literature[edit]

  • Andrew J. Hoffman, David E. Nichols: Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives. In: Journal of Medicinal Chemistry. 28, 1985, p. 1252–1255, doi:10.1021/jm00147a022.
  • V. J. Watts, R. B. Mailman, C. P. Lawler, K. A. Neve, D. E. Nichols: LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors. In: Psychopharmacology. 118, 1995, p. 401–409, doi:10.1007/BF02245940.
  • T. Niwaguchi, Y. Nakahara, H. Ishii: Studies on lysergic acid diethylamide and related compounds. IV. Syntheses of various amide derivatives of norlysergic acid and related compounds. In: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. Vol. 96, No. 5, May 1976, p. 673–678, PMID 987200.
  • Robert C. Pfaff, Xuemei Huang, Danuta Marona-Lewicka, Robert Oberlender and David E. Nichols: Lysergamides Revisited. In: NIDA Research Monograph 146: Hallucinogens: An Update. p. 52, 1994, United States Department of Health and Human Services.

See also[edit]

References[edit]

  1. ^ Hoffman AJ, Nichols DE (September 1985). "Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives". Journal of Medicinal Chemistry 28 (9): 1252–5. doi:10.1021/jm00147a022. PMID 4032428. 
  2. ^ ACMD (10 June 2014). "Update of the Generic Definition for Tryptamines". UK Home Office. p. 12. Retrieved 10 June 2014. 

External links[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/ETH-LAD — Please support Wikipedia.
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