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Dysdiadochokinesia
ICD-10 R27
ICD-9 781.3

Dysdiadochokinesia, dysdiadochokinesis, dysdiadokokinesia, dysdiadokokinesis (from Greek δυς dys "bad", διάδοχος diadochos "succeeding", κίνησις kinesis "movement"), often abbreviated as DDK, is the medical term for an impaired ability to perform rapid, alternating movements (i.e. diadochokinesia). Complete inability is called adiadochokinesia.

Causes[edit]

Dysdiadochokinesia is a feature of cerebellar ataxia and may be the result of lesions to either the cerebellar hemispheres or the frontal lobe (of the cerebrum), it can also be a combination of both.[1] It is thought to be caused by the inability to switch on and switch off antagonising muscle groups in a coordinated fashion due to hypotonia, secondary to the central lesion.[2]

Dysdiadochokinesia is also seen in Friedreich's ataxia and multiple sclerosis, as a cerebellar symptom (including ataxia, intention tremor and dysarthria). It is also a feature of ataxic dysarthria. Dysdiadochokinesia often presents in motor speech disorders (dysarthria), therefore testing for dysdiadochokinesia can be used for a differential diagnosis.[3]

Dysdiadochokinesia has been linked to a mutation in SLC18A2, which encodes vesicular monoamine transporter 2 (VMAT2).[4]

Presentation[edit]

Abnormalities in diadochokinesia can be seen in the upper extremity, lower extremity and in speech. The deficits become visible in the rate of alternation, the completeness of the sequence, and in the variation in amplitude involving both motor coordination and sequencing.[1][5] Average rate can be used as a measure of performance when testing for dysdiadochokinesia.[3] It is demonstrated clinically by asking the patient to tap the palm of one hand with the fingers of the other, then rapidly turn over the fingers and tap the palm with the back of them, repeatedly. This movement is known as a pronation/supination test of the upper extremity. A simpler method using this same concept is to ask the patient to demonstrate the movement of trying a doorknob or screwing in a light bulb. When testing for this condition in legs ask the patient to tap your hand as quickly as possible with the ball of each foot in turn. Movements tend to be slow or awkward. The feet normally perform less well than the hands.[6] When testing for dysdiadochokinesia with speech the patient is asked to repeat syllables such as /pə/, /tə/, and /kə/; variation, excess loudness, and irregular articular breakdown are signs of dysdiadochokinesia.[3]

References[edit]

  1. ^ a b Deshmukh, A; Rosenbloom, MJ, Pfefferbaum, A, & Sullivan EV (2002). "Clinical signs of cerebellar dysfunction in schizophrenia, alcoholism, and their comorbidity.". Schizophr Res. 57 ((2-3)): 281–291. doi:10.1016/s0920-9964(01)00300-0. PMID 12223260. 
  2. ^ "Dysdiadochokinesia", UBM Medica, United States. (2011). Retrieved May 11, 2011.
  3. ^ a b c Wang, YT; Kent, RD, Duffy, JR, & Thomas, JE (2008). "Analysis of diadochokinesis in ataxic dysarthria using the motor speech profile program". Folia Phoniatrica et Logopaedica 61 (1): 11. doi:10.1159/000184539. PMC 2790744. PMID 19088478. 
  4. ^ Rilstone, Jennifer; Alkhater, R; Minassian, B (2013). "Brain Dopamine-Serotonic Vesicular Transport Disease and Its Treatment". New England Journal Of Medicine 386 (6): 543–550. doi:10.1056/NEJMoa1207281. PMID 23363473. 
  5. ^ Diener, HC; Dichgans, J (1992). "Pathophysiology of Cerebellar Ataxia". Movement Disorders 7 (2): 95–109. doi:10.1002/mds.870070202. PMID 1584245. 
  6. ^ Bates Guide to Physical Examination, 8th Ed.

External links[edit]

Video Demonstrations

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205 videos foundNext > 

Dysmetria, Dysdiadochokinesia, & Rebound Phenomenon

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Adiadochokinesia

problem with rapid alternating movements.

Dysdiadochokinesia - simulation in cerebellar lesion

We have just tried to imitate a patient here.Your feedbacks are most welcome -- Dr.Raju Suresh Kumar (email:raju6712in@gmail.com)

How to Pronounce Dysdiadochokinesia

Learn how to say Dysdiadochokinesia correctly with EmmaSaying's "how do you pronounce" free tutorials. @---@---@---@---@---@---@---@---@---@---@---@---@---@ ...

The Case of RC - Dysdiadochokinesia

Cerebellar Test.

Dysdiadochokinesia

This video shows an example of dysdiadochokinesia, or difficulty with rapid alternating movements.

Abnormal Coordination Exam ; Hand Rapid Alternating Movements

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Cerebellar Examination - OSCE Guide

The ability to carry out a thorough and slick cerebellar examination is something every medic needs to master. This video aims to give you an idea of what's ...

Dysdiadochokinesia Song

An easy way to learn and to remember the definition of dysdiadochokinesia, a key neurologic sign in cerebellar disorders. Words: "Dysdiadochokinesia...indica...

dysdiadochokinesia

205 videos foundNext > 

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