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Disodium inosinate
Disodium inosinate.png
IUPAC name
Disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate[1]
Other names
Disodium 5'-inosinate
Sodium 5'-inosinate
Disodium inosine 5'-monophosphate
Inosine 5'-(disodium phosphate)
Sodium inosinate
4691-65-0  YesY N
ChemSpider 19594 YesY
Jmol-3D images Image
PubChem 20819
Molar mass 392.17 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Disodium inosinate (E631[2]) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P. It is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.

Use as a food additive[edit]

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.

As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract.

Toxicology and safety[edit]

In the United States, consumption of added 5'-ribonucleotides averages 4 mg per day, compared to 2 g per day of naturally occurring purines. A review of literature by an FDA committee found no evidence of carcinogenicity, teratogenicity, or adverse effects on reproduction.[3]

In 2004, disodium inosinate was removed from the food additive list by Codex Alimentarius Commission[4] (but it is still mentioned on the last (2009) codex alimentarius list).[5]

See also[edit]


  1. ^ PubChem 20819
  2. ^ Food Standards Australia New Zealand. "Food Additives- Numerical List". Retrieved 1 December 2009. 
  3. ^ DISODIUM 5'-GUANYLATE AND DISODIUM 5'-INOSINATE, Dr K. Ekelman and Dr K. C. Raffaele, Additives Evaluation Branch, Division of Health Effects Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA and other
  4. ^ Codex Alimentarius Commission. "Report of the 36th Session of the Codex Committee on Food Additives and Contaminants" (PDF). Retrieved 2 December 2009. 
  5. ^ "Class Names and the International Numbering System for Food Additives". Retrieved Aug 2010. 

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Disodium_inosinate — Please support Wikipedia.
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136 news items

The Verge
Mon, 28 Sep 2015 07:15:00 -0700

Contains: Soy, Fire Grilled Chicken: Chicken, water, seasoning (maltodextrin, dried garlic, salt, spices, natural flavor, carrageenan, dried onion, disodium inosinate & guanylate, citric acid, caramel color (C), garlic powder, onion powder), modified ...

Huffington Post

Huffington Post
Tue, 29 Sep 2015 13:15:00 -0700

I'm delighted to see food companies get rid of the likes of polysorbate 80, disodium inosinate, and polyglycerol polyricinoleate (PGPR), which are just chemical props for packaged foods that are typically high in salt or sugar. And I'm all in favor of ...


Thu, 24 Sep 2015 11:11:11 -0700

Also hates kittens," and disodium inosinate and guanylate, "an additive element that's kind of a mean jerk." Pizza, subs and burgers also make an appearance as "additive mother ships" that are "filled with additives, fueled by doom." According to ...

Gizmodo Australia

Gizmodo Australia
Thu, 24 Sep 2015 00:52:30 -0700

... food and then popular food products deconstructed to what they're made out of: Alginate, Annato, Anthocyanins, Ascorbic acid, different versionss of corn, Diacetyl, Disodium inosinate, Ethylenediaminetetraacetic acid, Ferrous sulfate… and you get ...


Sat, 05 Sep 2015 13:01:56 -0700

不過除了E621這個味精之外,標籤上常見的增味劑還包括鳥苷酸二鈉(Disodium Guanylate,E627)和肌苷酸二鈉(Disodium Inosinate,E631),它們大都是從魚及肉中提取出來,是否比味精健康不得而知。增味劑顧名思義,是無味變有味、乏味變好味的東西,兩者若 ...

NBC New York

NBC New York
Wed, 24 Jun 2015 07:38:10 -0700

A New Jersey-based company is voluntarily recalling nearly 10,000 cases of Wish-Bone Ranch salad dressing sold in 24-ounce bottles after a customer alerted representatives the product was accidentally mixed with Wish-Bone Blue Cheese dressing, which ...


Tue, 26 May 2015 14:45:00 -0700

Following in the footsteps of competitors like Panera Bread Company, Chipotle Mexican Grill, and Subway, two of Yum! Brands' flagship fast-food chains, Taco Bell and Pizza Hut, have announced the removal of a number of controversial ingredients from ...


Wed, 01 Jul 2015 06:01:16 -0700

Curious ingredients. Xanthan gum, prominent presence of disodium, in form of disodium guanylate, disodium inosinate, calcium disodium edta. These are all curious mainly because none of them sounds like something I would want to pour over my salad.

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