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Disodium inosinate
Disodium inosinate.png
IUPAC name
Disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate[1]
Other names
Disodium 5'-inosinate
Sodium 5'-inosinate
Disodium inosine 5'-monophosphate
Inosine 5'-(disodium phosphate)
Sodium inosinate
4691-65-0  YesY N
ChemSpider 19594 YesY
Jmol-3D images Image
PubChem 20819
Molar mass 392.17 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Disodium inosinate (E631[2]) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P. It is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.

Use as a food additive[edit]

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.

As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract.


Disodium inosinate is generally produced from meat or fish. Though it is normally a non-vegetarian product, it may be produced from tapioca starch without any animal products involved in the production. The producer can provide information on the origin and it is in some cases labeled as "vegetarian" in ingredients lists when produced from plant sources.[3][4]

Toxicology and safety[edit]

In the United States, consumption of added 5'-ribonucleotides averages 4 mg per day, compared to 2 g per day of naturally occurring purines. A review of literature by an FDA committee found no evidence of carcinogenicity, teratogenicity, or adverse effects on reproduction.[5]

In 2004, disodium inosinate was removed from the food additive list by Codex Alimentarius Commission[6] (but it is still mentioned on the last (2009) codex alimentarius list).[7]

See also[edit]


  1. ^ PubChem 20819
  2. ^ Food Standards Australia New Zealand. "Food Additives- Numerical List". Retrieved 1 December 2009. 
  3. ^ "E-numbers : E631 : Sodium inosinate". Food-Info.net. 1998-09-27. Retrieved 2013-02-04. 
  4. ^ http://www.pepsicoindia.co.in/Download/All%20PepsiCo%20India%20food%20products%20and%20their%20ingredients%20are%20100per%20vegetarian-FAQs.pdf
  5. ^ DISODIUM 5'-GUANYLATE AND DISODIUM 5'-INOSINATE, Dr K. Ekelman and Dr K. C. Raffaele, Additives Evaluation Branch, Division of Health Effects Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA and other
  6. ^ Codex Alimentarius Commission. "Report of the 36th Session of the Codex Committee on Food Additives and Contaminants" (PDF). Retrieved 2 December 2009. 
  7. ^ "Class Names and the International Numbering System for Food Additives". Retrieved Aug 2010. 

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Disodium_inosinate — Please support Wikipedia.
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123 news items

WDEF News 12

WDEF News 12
Mon, 18 May 2015 11:45:00 -0700

They have the taste right - but - MSG? disodium inosinate? disodium gulanylate? calcium disodium EDTA? Come on...clean up those ingredients! 2 tablespoons 100 calories, 11 grams of fat, 210 mg of sodium. Please! We love our ranch! Retails for $3.59 for ...
The Intelligencer (blog)
Tue, 19 May 2015 11:44:09 -0700

Lacking any animal products, these crispy bites are made of artificially flavored textured soy flour and other ingredients including caramel color, maltodextrin, yeast extract, and flavor enhancers called disodium inosinate and disodium guanylate.


Tue, 05 May 2015 10:56:27 -0700

... Dipotassium Sulfate; Disodium Guanylate (GMP); Disodium Inosinate (IMP); EDTA (Calcium Disodium EDTA/Disodium Dihydrogen EDTA); Esters of Fatty Acids; Ethoxyquin; Fat Substitutes (Sucrose Polyester, Microparticulated Whey Protein Concentrate); ...

Huffington Post

Huffington Post
Thu, 16 Apr 2015 07:26:15 -0700

Don't get us wrong: Dunkin' Donuts has a wide menu of food and drinks that are, in general, pretty tasty. The doughnuts are definitely still solid, for the most part, and the coffee is also worthy of praise. But there are some items that you really ...

Houston Press

Houston Press
Wed, 25 Feb 2015 05:15:59 -0800

The third incorporated water, miso paste and Ajinomoto Hondashi, a prepared dashi soup mix that includes MSG as well as disodium inosinate, another salt that works in conjunction with the MSG to provide that umami flavor. The test was repeated with a ...
Thu, 12 Mar 2015 08:56:15 -0700

Subway locations in the U.S. have quietly subtracted disodium guanylate and disodium inosinate—both flavor enhancers that lend foods like Doritos a savoriness—from their chicken marinade in recent months, although the additives remain in certain ...

Springfield News-Leader

Springfield News-Leader
Fri, 13 Mar 2015 14:22:30 -0700

•Marie Callender's: Beef, water, pork, soy protein color, salt, flavoring, beef flavor (beef flavor contains autolyzed yeast extract, disodium inosinate, disodium guanylate ..." But you can also make your own Salisbury steak or buy one at a restaurant ...
Minneapolis Star Tribune
Wed, 26 Nov 2014 08:11:03 -0800

There's also a chicken-flavored base that, of course, like the chicken and salsa, itself contains a few things, such as yeast extract and disodium inosinate, not found in normal kitchens. But, although Mr. Tidbit agrees that it's come to a pretty pass ...

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