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Disodium inosinate
Disodium inosinate.png
CAS number 4691-65-0  YesY N
PubChem 20819
ChemSpider 19594 YesY
Jmol-3D images Image 1
Image 2
Molecular formula C10H11N4Na2O8P
Molar mass 392.17 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Disodium inosinate (E631[2]) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P. It is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.

Use as a food additive[edit]

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.

As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract.


Disodium inosinate, also known as disodium 5’-inosinate, comes from nucleotide, inosine monophosphate (IMP).In the flavor industry, disodium inosinate and disodium guanylate together known as disodium ribotides (“I + G.”).A small amount of I + G may be added to a food to replace some monosodium glutamate (MSG).Leading manufacturers of disodium guanylate and disodium inosinate produce I + G by microbial fermentation. Their growth media usually consisting mainly of tapioca starch. Few companies also produce I + G from yeast.

Toxicology and safety[edit]

In the United States, consumption of added 5'-ribonucleotides averages 4 mg per day, compared to 2 g per day of naturally occurring purines. A review of literature by an FDA committee found no evidence of carcinogenicity, teratogenicity, or adverse effects on reproduction.[3]

In 2004, disodium inosinate was removed from the food additive list by Codex Alimentarius Commission[4] (but it is still mentioned on the last (2009) codex alimentarius list).[5]

See also[edit]


  1. ^ PubChem 20819
  2. ^ Food Standards Australia New Zealand. "Food Additives- Numerical List". Retrieved 1 December 2009. 
  3. ^ DISODIUM 5'-GUANYLATE AND DISODIUM 5'-INOSINATE, Dr K. Ekelman and Dr K.C.Raffaele, Additives Evaluation Branch, Division of Health Effects Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA and other
  4. ^ Codex Alimentarius Commission. "Report of the 36th Session of the Codex Committee on Food Additives and Contaminants". Retrieved 2 December 2009. 
  5. ^ "Class Names and the International Numbering System for Food Additives". Retrieved Aug 2010. 

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3 news items

New Zealand Herald
Fri, 12 Sep 2014 10:01:32 -0700

These are disodium guanylate (627) and disodium inosinate (631). Both are used in processed foods to enhance the flavour of a food. My recommendations. This is a case of too many flavour enhancers spoil the pot. If you want breadcrumbs with parmesan ...
Durham Times
Tue, 16 Sep 2014 09:07:30 -0700

If you're buying powdered stock or using stock cubes, check the ingredients and ignore those that have salt, monosodium glutamate, disodium guanylate, disodium inosinate or similar or other flavour enhancers as their main ingredients (the first item on ...
Đời Sống & Pháp Luật
Tue, 09 Sep 2014 00:08:54 -0700

Ngoài ra, theo kết quả kiểm nghiệm của trung tâm Khoa học công nghệ sắc ký Hải Đăng còn cho thấy, mẫu gia vị trong gói mì này còn chứa 8/kg Disodium Inosinate và Disodium Guanylate và 0,49% hàm lượng bột ngọt (monosodium glutamate). Đỉnh cao ...

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