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Disodium inosinate
Disodium inosinate.png
IUPAC name
Disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate[1]
Other names
Disodium 5'-inosinate
Sodium 5'-inosinate
Disodium inosine 5'-monophosphate
Inosine 5'-(disodium phosphate)
Sodium inosinate
4691-65-0  YesY N
ChemSpider 19594 YesY
Jmol-3D images Image
PubChem 20819
Molar mass 392.17 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Disodium inosinate (E631[2]) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P. It is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.

Use as a food additive[edit]

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.

As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract.


Disodium inosinate is generally produced from meat or fish. Though it is normally a non-vegetarian product, it may be produced from tapioca starch without any animal products involved in the production. The producer can provide information on the origin and it is in some cases labeled as "vegetarian" in ingredients lists when produced from plant sources.[3][4]

Toxicology and safety[edit]

In the United States, consumption of added 5'-ribonucleotides averages 4 mg per day, compared to 2 g per day of naturally occurring purines. A review of literature by an FDA committee found no evidence of carcinogenicity, teratogenicity, or adverse effects on reproduction.[5]

In 2004, disodium inosinate was removed from the food additive list by Codex Alimentarius Commission[6] (but it is still mentioned on the last (2009) codex alimentarius list).[7]

See also[edit]


  1. ^ PubChem 20819
  2. ^ Food Standards Australia New Zealand. "Food Additives- Numerical List". Retrieved 1 December 2009. 
  3. ^ "E-numbers : E631 : Sodium inosinate". Food-Info.net. 1998-09-27. Retrieved 2013-02-04. 
  4. ^ http://www.pepsicoindia.co.in/Download/All%20PepsiCo%20India%20food%20products%20and%20their%20ingredients%20are%20100per%20vegetarian-FAQs.pdf
  5. ^ DISODIUM 5'-GUANYLATE AND DISODIUM 5'-INOSINATE, Dr K. Ekelman and Dr K. C. Raffaele, Additives Evaluation Branch, Division of Health Effects Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA and other
  6. ^ Codex Alimentarius Commission. "Report of the 36th Session of the Codex Committee on Food Additives and Contaminants" (PDF). Retrieved 2 December 2009. 
  7. ^ "Class Names and the International Numbering System for Food Additives". Retrieved Aug 2010. 

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Disodium_inosinate — Please support Wikipedia.
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129 news items

Tryon Daily Bulletin
Thu, 13 Aug 2015 19:15:00 -0700

Many of us eat out on weekends, and many restaurant dishes are loaded with different types of sodium like disodium phosphate, monosodium glutamate, sodium chloride (table salt), and disodium inosinate. The reason salt (sodium) can make you gain weight ...


Tue, 26 May 2015 14:45:00 -0700

Following in the footsteps of competitors like Panera Bread Company, Chipotle Mexican Grill, and Subway, two of Yum! Brands' flagship fast-food chains, Taco Bell and Pizza Hut, have announced the removal of a number of controversial ingredients from ...


Wed, 01 Jul 2015 06:01:16 -0700

Curious ingredients. Xanthan gum, prominent presence of disodium, in form of disodium guanylate, disodium inosinate, calcium disodium edta. These are all curious mainly because none of them sounds like something I would want to pour over my salad.

NBC New York

NBC New York
Wed, 24 Jun 2015 07:38:10 -0700

A New Jersey-based company is voluntarily recalling nearly 10,000 cases of Wish-Bone Ranch salad dressing sold in 24-ounce bottles after a customer alerted representatives the product was accidentally mixed with Wish-Bone Blue Cheese dressing, which ...

Tin tức 24h

Tin tức 24h
Sat, 22 Aug 2015 23:06:16 -0700

Cụ thể: Isodium Guanylate - chất điều vị E627 và Disodium Inosinate - chất điều vị E631, trong thành phần của hạt nêm là hai chất điều vị siêu ngọt, hay còn gọi là tạo ngọt giả tạo. Vị ngọt của hai chất này còn gấp 5 lần mì chính vì thành phần chính ...


Tue, 07 Jul 2015 03:12:50 -0700

Disodium inosinate multiplies the umami taste of MSG by a factor of six or eight. Carrageenen, made from seaweed flour, binds up fats and proteins in chocolate milk and is also used in everything from salad dressing to beer (and air fresheners, shoe ...


Wed, 12 Aug 2015 13:48:45 -0700

不過除了E621這個味精之外,標籤上常見的增味劑還包括鳥苷酸二鈉(Disodium Guanylate,E627)和肌苷酸二鈉(Disodium Inosinate,E631),它們大都是從魚及肉中提取出來,是否比味精健康不得而知。增味劑顧名思義,是無味變有味、乏味變好味的東西,兩者若 ...
Thu, 04 Jun 2015 11:32:06 -0700

Subway will change its chicken strips, for example, to remove artificial flavors, the "flavor enhancers" disodium guanylate and disodium inosinate, and the preservative succinic acid, according to the chain. Sauces such as teriyaki sauce and sweet ...

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