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Disodium inosinate
Disodium inosinate.png
IUPAC name
Disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate[1]
Other names
Disodium 5'-inosinate
Sodium 5'-inosinate
Disodium inosine 5'-monophosphate
Inosine 5'-(disodium phosphate)
Sodium inosinate
4691-65-0  YesY N
ChemSpider 19594 YesY
Jmol interactive 3D Image
PubChem 20819
Molar mass 392.17 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Disodium inosinate (E631[2]) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P. It is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.

Use as a food additive[edit]

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.

As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract.


Disodium inosinate is generally produced from meat or fish. Though it is normally a non-vegetarian product, it may be produced from tapioca starch without any animal products involved in the production. The producer can provide information on the origin and it is in some cases labeled as "vegetarian" in ingredients lists when produced from plant sources.[3][4]

Toxicology and safety[edit]

In the United States, consumption of added 5'-ribonucleotides averages 4 mg per day, compared to 2 g per day of naturally occurring purines. A review of literature by an FDA committee found no evidence of carcinogenicity, teratogenicity, or adverse effects on reproduction.[5]

In 2004, disodium inosinate was removed from the food additive list by Codex Alimentarius Commission[6] (but it is still mentioned on the last (2009) codex alimentarius list).[7]

See also[edit]


  1. ^ CID 20819 from PubChem
  2. ^ Food Standards Australia New Zealand. "Food Additives- Numerical List". Retrieved 1 December 2009. 
  3. ^ "E-numbers : E631 : Sodium inosinate". Food-Info.net. 1998-09-27. Retrieved 2013-02-04. 
  4. ^ http://www.pepsicoindia.co.in/Download/All%20PepsiCo%20India%20food%20products%20and%20their%20ingredients%20are%20100per%20vegetarian-FAQs.pdf
  5. ^ DISODIUM 5'-GUANYLATE AND DISODIUM 5'-INOSINATE, Dr K. Ekelman and Dr K. C. Raffaele, Additives Evaluation Branch, Division of Health Effects Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA and other
  6. ^ Codex Alimentarius Commission. "Report of the 36th Session of the Codex Committee on Food Additives and Contaminants" (PDF). Retrieved 2 December 2009. 
  7. ^ "Class Names and the International Numbering System for Food Additives". Retrieved Aug 2010. 

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Disodium_inosinate — Please support Wikipedia.
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193 news items

The Epoch Times

The Epoch Times
Fri, 29 Jan 2016 11:34:59 -0800

To cater to the 39 percent of people who seek new or ethnic flavors, it created Chex Mix Xtreme Sweet & Spicy Sriracha, with 27 ingredients, including distilled Monoglycerides, Maltodextrin, Disodium Inosinate, and BHT. It also created Pillsbury Melts ...


Mon, 05 Oct 2015 10:49:17 -0700

Take an apparently nutritious rice bowl with chicken. It would seem like the healthy choice, except that often, it's not—often it's chock full of unnecessary ingredients and additives like disodium guanylate or disodium inosinate in rice. Or petroleum ...

New York Times

New York Times
Mon, 09 Nov 2015 10:30:40 -0800

Mr. Fellows was asked for a more thorough overhaul aimed at getting rid of ingredients that are out of favor, things like monosodium glutamate, or MSG, and disodium inosinate and disodium guanylate, which enhance flavor, as well as things like ...

Washington Post

Washington Post
Thu, 29 Oct 2015 07:03:35 -0700

Row 4: Sugar, dehydrated mechanically separated chicken, dehydrated onions, cooked chicken skins, sodium phosphate, flavoring. Row 5: Spices, beta-carotene for color, dehydrated vegetable broth, disodium guanylate, disodium inosinate, dehydrated ...

The Verge

The Verge
Mon, 28 Sep 2015 07:15:00 -0700

Contains: Milk, Premium Latin Rice: Enriched long grain rice, seasoning (salt, natural flavor, sugar, maltodextrin, dried parsley, onion powder, garlic powder, dried cilantro, disodium inosinate & guanylate)., Seasoned Beef: Beef, water, seasoning ...

U.S. News & World Report

U.S. News & World Report
Wed, 16 Dec 2015 09:15:00 -0800

It is removing disodium inosinate and monosodium glutamate and eight other ingredients from two children's chicken soup varieties while adding flavors such as dehydrated chicken broth and onions. It's a test to see how customers react before ...

Fox 32 Chicago

Fox 32 Chicago
Fri, 30 Oct 2015 13:48:45 -0700

Earlier this month, Chipotle released a spot featuring the fictitious “Cheapotle” — an additive-filled rip-off of the Mexican Grill-- that tries to serve a customer a chicken rice bowl with additives like disodium guanylate and disodium inosinate ...


Thu, 24 Sep 2015 11:11:11 -0700

Also hates kittens," and disodium inosinate and guanylate, "an additive element that's kind of a mean jerk." Pizza, subs and burgers also make an appearance as "additive mother ships" that are "filled with additives, fueled by doom." According to ...

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