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Disodium inosinate
Disodium inosinate.png
IUPAC name
Disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate[1]
Other names
Disodium 5'-inosinate
Sodium 5'-inosinate
Disodium inosine 5'-monophosphate
Inosine 5'-(disodium phosphate)
Sodium inosinate
4691-65-0  YesY N
ChemSpider 19594 YesY
Jmol interactive 3D Image
PubChem 20819
Molar mass 392.17 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Disodium inosinate (E631[2]) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P. It is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks.

Use as a food additive[edit]

Disodium inosinate is used as a flavor enhancer, in synergy with monosodium glutamate (MSG) to provide the umami taste. It is often added to foods in conjunction with disodium guanylate; the combination is known as disodium 5'-ribonucleotides.

As a relatively expensive product, disodium inosinate is usually not used independently of glutamic acid; if disodium inosinate is present in a list of ingredients, but MSG does not appear to be, it is possible that glutamic acid is provided as part of another ingredient or is naturally occurring in another ingredient like tomatoes, Parmesan cheese or yeast extract.


Disodium inosinate is generally produced from meat or fish. Though it is normally a non-vegetarian product, it may be produced from tapioca starch without any animal products involved in the production. The producer can provide information on the origin and it is in some cases labeled as "vegetarian" in ingredients lists when produced from plant sources.[3][4]

Toxicology and safety[edit]

In the United States, consumption of added 5'-ribonucleotides averages 4 mg per day, compared to 2 g per day of naturally occurring purines. A review of literature by an FDA committee found no evidence of carcinogenicity, teratogenicity, or adverse effects on reproduction.[5]

In 2004, disodium inosinate was removed from the food additive list by Codex Alimentarius Commission[6] (but it is still mentioned on the last (2009) codex alimentarius list).[7]

See also[edit]


  1. ^ PubChem 20819
  2. ^ Food Standards Australia New Zealand. "Food Additives- Numerical List". Retrieved 1 December 2009. 
  3. ^ "E-numbers : E631 : Sodium inosinate". Food-Info.net. 1998-09-27. Retrieved 2013-02-04. 
  4. ^ http://www.pepsicoindia.co.in/Download/All%20PepsiCo%20India%20food%20products%20and%20their%20ingredients%20are%20100per%20vegetarian-FAQs.pdf
  5. ^ DISODIUM 5'-GUANYLATE AND DISODIUM 5'-INOSINATE, Dr K. Ekelman and Dr K. C. Raffaele, Additives Evaluation Branch, Division of Health Effects Evaluation, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA and other
  6. ^ Codex Alimentarius Commission. "Report of the 36th Session of the Codex Committee on Food Additives and Contaminants" (PDF). Retrieved 2 December 2009. 
  7. ^ "Class Names and the International Numbering System for Food Additives". Retrieved Aug 2010. 

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Disodium_inosinate — Please support Wikipedia.
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