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Desomorphine molecule ball.png
Systematic (IUPAC) name
Clinical data
Trade names Permonid
Physical: Very high
Psychological: Very high
Very high
Legal status
Legal status
CAS Number 427-00-9 N
ATC code none
PubChem CID 5362456
ChemSpider 4515044 YesY
UNII 7OP86J5E33 YesY
Synonyms Desomorphine, dihydrodesoxymorphine, Permonid
Chemical data
Formula C17H21NO2
Molar mass 271.354 g/mol
 NYesY (what is this?)  (verify)

Desomorphine (dihydrodesoxymorphine, former brand name Permonid, street name krokodil) is a derivative of morphine with powerful, fast-acting opioid effects, such as sedation and analgesia.[1][2][3][4] First synthesized in 1932 and patented in 1934,[5] desomorphine was used in Switzerland under the brand name Permonid[6] and was described as having a fast onset and a short duration of action, with relatively little nausea or respiratory depression compared to equivalent doses of morphine. Dose-by-dose it is eight to ten times more potent than morphine.[7]

Desomorphine is derived from morphine where the 6-hydroxyl group and the 7,8 double bond have been reduced.[5] The traditional synthesis of desomorphine starts from α-chlorocodide, which is itself obtained by reacting thionyl chloride with codeine. By catalytic reduction, α-chlorocodide gives dihydrodesoxycodeine, which yields desomorphine on demethylation.[8][9]



Desomorphine was previously used in Switzerland and Russia for the treatment of severe pain; although for many years up to 1981, when its use was terminated, it was being used to treat a single person in Bern, Switzerland with a rare illness.[10][not in citation given]


Desomorphine abuse in Russia attracted international attention in 2010 due to an increase in clandestine production, presumably due to its relatively simple synthesis from codeine available over-the-counter. Abuse of homemade desomorphine was first reported in Siberia in 2003 when Russia started a major crackdown on heroin production and trafficking, but has since spread throughout Russia and the neighboring former Soviet republics.[10]

The drug can be made from codeine and iodine derived from OTC[clarification needed] medications and red phosphorus from match strikers,[11] in a process similar to the manufacturing of methamphetamine from pseudoephedrine. Like methamphetamine, desomorphine made this way is often contaminated with various agents. The street name in Russia for homemade desomorphine is krokodil (Russian: крокодил, crocodile), possibly related to the chemical name of the precursor α-chlorocodide, or similarity of a skin, damaged by the drug use, to crocodile leather.[10] Due to difficulties in procuring heroin, combined with easy and cheap access to over-the-counter pharmacy products containing codeine in Russia, use of krokodil increased until 2012.[12] In 2012 the Russian federal government introduced new restrictions for the sale of codeine-containing medications. This policy change likely diminished, but did not extinguish krokodil use in Russia.[13] It has been estimated that around 100,000 people use krokodil in Russia and around 20,000 in Ukraine.[12] One death in Poland in December 2011 was also believed to have been caused by krokodil use, and its use has been confirmed among Russian expatriate communities in a number of other European countries.[14]

Adverse effects[edit]


Illicitly produced desomorphine typically contains large amounts of toxic substances as a result of being "cooked" and used without any significant effort to remove the byproducts and leftovers from synthesis. Injecting any such mixture can cause serious damage to the skin, blood vessels, bone and muscles, sometimes requiring limb amputation in long-term users.[7] Causes of this damage are from iodine and phosphorus (and other toxic substances) that are present after synthesis. The large volume of tissue damage/infection is what gained the drug its nickname of the flesh-eating drug, as homemade versions made by suppliers and users contain multiple impurities and toxic substances that lead to such tissue damage/infection (the pure form of the drug itself would not cause this damage).[15] Gangrene, phlebitis, thrombosis (blood clots), pneumonia, meningitis, septicaemia (blood infection), osteomyelitis (bone infection), liver & kidney damage, brain damage and HIV/AIDS are also common amongst users of krokodil.[12] Sometimes, the user will miss the vein when injecting the desomorphine, creating abscess and causing death of the flesh surrounding the entry-point.[7] Test subjects were subjected to desomorphine intake. The completed tests on animal subjects produced results that contrast desomorphine to morphine. Compared to morphine, the results show increased toxicity, more potent relief of pain, higher levels of general depression, decreased respiration, and increased digestive activity.[16]

Reinforcement disorders[edit]

Early medical trials of humans taking desomorphine have resulted in the finding that, like morphine and most other analgesics of the morphine type, small amounts are highly addictive and tolerance to the drug develops quickly. However, though tolerance to respiratory depression with repeated doses was observed in rats, early clinical trials failed to show any tolerance to these same effects with repeated doses in humans.[16]

Physical and chemical properties[edit]

Desomorphine has a molecular weight of 271.35 g/mol and three salts are used: hydrobromide (free-base conversion ratio 0.770), hydrochloride (0.881) and sulfuric acid(0.802).[17] Its freebase form is slightly soluble in water (1.425 g/L at 25 °C), although its salts are very water-soluble; its freebase form is also very soluble in most polar organic solvents (like acetone, ethanol and ethyl acetate).[7] Its melting point is 189 °C.[7] It has a pKa of 9.69.[7] Desomorphine comes in four isoforms, A, B, C, and D[18] and the latter two appear to be the more researched and used.

Krokodil is made from codeine mixed with other substances. The codeine is retrieved from over-the-counter medicine and is then mixed with ethanol, gasoline, red phosphorus, iodine, hydrochloric acid and paint thinner.[7] Toxic nitrogen oxides fumes emerge from the drug when heated.[19]


Desomorphine was first synthesised in the U.S. in 1932 and patented on November 13, 1934.[10] In Russia, desomorphine was declared an illegal narcotic analgesic in 1998. However, while codeine-containing drugs generally have been prescription products in Europe, in Russia they were sold freely over-the-counter until June 2012.[20] The number of users in Russia was estimated to have reached around one million at the peak of the drug's popularity.[21]

Society and culture[edit]

Legal status[edit]

In the US, desomorphine is a Schedule 1 controlled substance, indicating that the United States FDA has determined that there are no legal medicinal uses for desomorphine in the U.S. It has maintained this status as a controlled substance in the United States since 1936.[16] The drug is a Narcotic in Schedule I of the Controlled Substances Act 1970 of the United States as drug number (ACSCN) 9055. It is therefore subject to annual aggregate manufacturing quotas in the United States, and in 2014 the quota for desomorphine was 5 grams.[22] It is produced as a hydrochloride (free base conversion ratio 0.85) and sulphate (0.80)[23]

Western media[edit]

The media in the U.S. and Canada have brought awareness to desomorphine. There have been incidents reported where desomorphine had supposedly been present within either country but no incidents have been confirmed by any drug-testing reports.[24][25]


  1. ^ Casy, Alan F.; Parfitt, Robert T. (1986). Opioid analgesics: chemistry and receptors. New York: Plenum Press. p. 32. ISBN 978-0-306-42130-3. 
  2. ^ Bognar, R; Makleit, S (1958). "Neue Methode für die Vorbereitung von dihydro-6-desoxymorphine" [New method for the preparation of dihydro-6-desoxymorphine]. Arzneimittel-Forschung (in German) 8 (6): 323–5. PMID 13546093. 
  3. ^ Janssen, Paul A. J. (1962). "A Review of the Chemical Features Associated with Strong Morphine-Like Activity". British Journal of Anaesthesia 34 (4): 260–8. doi:10.1093/bja/34.4.260. PMID 14451235. 
  4. ^ Sargent, Lewis J.; May, Everette L. (1970). "Agonists-antagonists derived from desomorphine and metopon". Journal of Medicinal Chemistry 13 (6): 1061–3. doi:10.1021/jm00300a009. PMID 4098039. 
  5. ^ a b US patent 1980972, Lyndon Frederick Small, "Morphine Derivative and Processes", published 1934-19-07, issued 1934-13-11 
  6. ^ "Krokodil". New York State Office of Alcoholism and Substance Abuse Services. 
  7. ^ a b c d e f g Katselou, M; Papoutsis, I; Nikolaou, P; Spiliopoulou, C; Athanaselis, S (May 2014). "A "Krokodil" emerges from the murky waters of addiction. Abuse trends of an old drug.". Life Sciences 102 (2): 81–87. doi:10.1016/j.lfs.2014.03.008. PMID 24650492. 
  8. ^ Mosettig, Erich; Cohen, Frank L.; Small, Lyndon F. (1932). "Desoxycodeine Studies. III. The Constitution of the So-Called α-Dihydrodesoxycodeine: Bis-Dihydrodesoxycodeine". Journal of the American Chemical Society 54 (2): 793–801. doi:10.1021/ja01341a051. 
  9. ^ Eddy, Nathan B.; Howes, Homer A. (1935). "Studies of Morphine, Codeine and their Derivatives X. Desoxymorphine-C, Desoxycodeine-C and their Hydrogenated Derivatives". Journal of Pharmacology and Experimental Therapeutics 55 (3): 257–67. 
  10. ^ a b c d Gahr, M; Freudenmann, RW; Hiemke, C; Gunst, IM; Connemann, BJ; Schönfeldt-Lecuona, C (2012). "Desomorphine goes "crocodile".". Journal of Addictive Diseases 31 (4): 407–12. doi:10.1080/10550887.2012.735570. PMID 23244560. 
  11. ^ Savchuk, S. A.; Barsegyan, S. S.; Barsegyan, I. B.; Kolesov, G. M. (2011). "Chromatographic study of expert and biological samples containing desomorphine". Journal of Analytical Chemistry 63 (4): 361–70. doi:10.1134/S1061934808040096. 
  12. ^ a b c Grund JP, Latypov A, Harris M (2013). "Breaking worse: The emergence of krokodil and excessive injuries among people who inject drugs in Eurasia". International Journal of Drug Policy 24 (4): 265–274. doi:10.1016/j.drugpo.2013.04.007. PMID 23726898. 
  13. ^ Zheluk A, Quinn C, Meylakhs P (2014). "Internet Search and Krokodil in the Russian Federation: An Infoveillance Study". Journal of Medical Internet Research 16 (9): e212. doi:10.2196/jmir.3203. PMID 25236385. 
  14. ^ Skowronek R, Celiński R, Chowaniec C (2012). ""Crocodile" – new dangerous designer drug of abuse from the East". Clinical Toxicology 50 (4): 269. doi:10.3109/15563650.2012.660574. PMID 22385107. 
  15. ^ "Desomorphine (Krokodil) Basics". Erowid. Retrieved 3 April 2014. 
  16. ^ a b c "DESOMORPHINE (Dihydrodesoxymorphine; dihydrodesoxymorphine-D; Street Name: Krokodil, Crocodil" (PDF). Drug Enforcement Administration. Retrieved 3 April 2014. 
  17. ^ "Permonid". PubChem Compound. National Library of Medicine. Retrieved 5 May 2014. 
  18. ^ http://books.google.com/books?id=DeX7jgInYFMC&pg=PA47#v=onepage&q&f=false
  19. ^ "Desomorphine". Specialized Information Services. Retrieved 3 April 2014. 
  20. ^ Берсенева А. (23 June 2011). "Без рецепта не обезболят". Gazeta.ru. Retrieved 12 January 2014. 
  21. ^ "Krokodil". New York State Office of Alcoholism and Substance Abuse Services. Retrieved 3 April 2014. 
  22. ^ http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm
  23. ^ http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html
  24. ^ No Confirmed Reports of Desomorphine ( "Krokodil" / "Crocodile" ) in Canada (PDF). Canadian Centre on Substance Abuse. November 21, 2013. ISBN 978-1-77178-052-0. 
  25. ^ "‘Krokodil’ in the United States Is an Urban Legend and Not a Medical Fact". The American Journal of Medicine. Retrieved July 2014. 

External links[edit]

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Desomorphine — Please support Wikipedia.
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436 news items

Slate Magazine (blog)

Slate Magazine (blog)
Mon, 18 Nov 2013 06:42:04 -0800

Krokodil, or desomorphine, is a cheap heroin substitute. You get it by mixing codeine with paint thinner, gasoline, and several other toxic ingredients. The drug first popped up in Eastern Europe early last decade, and appears to be relatively popular ...

Nature World News

Nature World News
Fri, 27 Sep 2013 06:00:21 -0700

Desomorphine, a drug that eats away flesh, has now emerged in the U.S. The first two suspected cases of the drug-use in the country were recently reported in Arizona. Desomorphine is a drug that's several times more potent than morphine. The drug ...


Tue, 26 Apr 2016 07:30:24 -0700

... del#Krokodil, ¿mito o realidad? buff.ly/1NsmhCk… vía @amplia2mente #DrogasEmergentes #Desomorfina. 2 dagen geleden. @chanivito: The advance of#Krokodil, myth or reality? buff.ly/23UdroH… vía @amplia2mente #EmergingDrugs #Desomorphine.

Guardian Express

Guardian Express
Mon, 14 Oct 2013 17:18:37 -0700

Scientists in the U.S. discovered desomorphine in 1932 while in the process of finding a less addictive substitute for morphine. In preclinical trials, desomorphine indicated low addiction possibilities, but in human trials, it showed a probability of ...

vestnik kavkaza

vestnik kavkaza
Wed, 19 Nov 2014 07:58:40 -0800

Desomorphine den eliminated in MakhachkalaA desomorphine den has been eliminated in Makhachkala. The ten was established by a citizen of Bahrain, a 21-year-old Ali Almutava.Almutava has been living in Makhachkala for several years with the ...

The Independent

The Independent
Tue, 21 Jun 2011 16:02:07 -0700

It is desomorphine, a synthetic opiate many times more powerful than heroin that is created from a complex chain of mixing and chemical reactions, which the addicts perform from memory several times a day. While heroin costs from £20 to £60 per dose, ...

Fox 59

Fox 59
Mon, 08 Feb 2016 13:36:38 -0800

Deputies said through conversations with an undercover officer, they were expecting to buy the drug desomorphine. It's also referred to as "krokodil" because the drug is known to eat away at flesh. “It will kinda put you in a zombie state. Some people ...


Mon, 07 Oct 2013 11:43:43 -0700

Recently various media outlets have been hyping a drug that cuts out the middleman and does the flesh eating all on its own: krokodil, a homemade version of desomorphine that originated in Russia as a heroin substitute. Last month health officials in ...

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