Learn and talk about DCP2, Human proteins

This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see Disease Control Priorities Project.

DCP2 decapping enzyme homolog (S. cerevisiae)

Identifiers

Symbols

DCP2; NUDT20

External IDs

OMIM: 609844 MGI: 1917890 HomoloGene: 13968 GeneCards: DCP2 Gene

EC number

3.6.1.62

Gene Ontology
Molecular function	• RNA binding • protein binding • exoribonuclease activity, producing 5'-phosphomonoesters • manganese ion binding • m7G(5')pppN diphosphatase activity
Cellular component	• cytoplasmic mRNA processing body • nucleus • cytosol • RNA-induced silencing complex
Biological process	• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • mRNA catabolic process • gene expression • RNA metabolic process • mRNA metabolic process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • histone mRNA catabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
112.31 – 112.36 Mb

Chr 18:
44.38 – 44.42 Mb

PubMed search

[1]

[2]

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.^[1]^[2]^[3]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[3]

Interactions [edit]

DCP2 has been shown to interact with DCP1A^[4] and UPF1.^[2]^[5]

References [edit]

^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A 99 (20): 12663–8. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.
^ ^a ^b Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
^ ^a ^b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".
^ Lykke-Andersen, Jens (Dec. 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. (United States) 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.
^ Lejeune, Fabrice; Li Xiaojie, Maquat Lynne E (Sep. 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell (United States) 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413.

Further reading [edit]

Ueno K, Kumagai T, Kijima T, et al. (1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer.". Hum. Genet. 102 (1): 63–8. doi:10.1007/s004390050655. PMID 9490301.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
van Dijk E, Cougot N, Meyer S, et al. (2004). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.". EMBO J. 21 (24): 6915–24. doi:10.1093/emboj/cdf678. PMC 139098. PMID 12486012.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.". RNA 8 (12): 1489–501. PMC 1370355. PMID 12515382.
Grzymski EC (2003). "Visualizing an mRNA destruction line.". Nat. Struct. Biol. 10 (6): 416. doi:10.1038/nsb0603-416. PMID 12768200.
Piccirillo C, Khanna R, Kiledjian M (2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2.". RNA 9 (9): 1138–47. doi:10.1261/rna.5690503. PMC 1370477. PMID 12923261.
Lejeune F, Li X, Maquat LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.". Mol. Cell 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cougot N, Babajko S, Séraphin B (2004). "Cytoplasmic foci are sites of mRNA decay in human cells.". J. Cell Biol. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Liu SW, Jiao X, Liu H, et al. (2004). "Functional analysis of mRNA scavenger decapping enzymes.". RNA 10 (9): 1412–22. doi:10.1261/rna.7660804. PMC 1370627. PMID 15273322.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.". Nat. Cell Biol. 7 (7): 719–23. doi:10.1038/ncb1274. PMC 1855297. PMID 15937477.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.". Mol. Cell 20 (6): 905–15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.". PLoS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.
Chu CY, Rana TM (2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.". PLoS Biol. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

v t e Post-transcriptional modification

Nuclear	Precursor mRNA 5′ cap formation Polyadenylation CPSF CstF PAP PAB2 CFI CFII Poly(A)-binding protein RNA splicing: intron/exon snRNP spliceosome minor spliceosome U1 alternative splicing pre-mRNA processing factor PLRG1 PRPF3 PRPF4 PRPF4B PRPF6 PRPF8 PRPF18 PRPF19 PRPF31 PRPF38A PRPF38B PRPF39 PRPF40A PRPF40B RNA editing Polyuridylation

Cytosolic	5′ cap methylation Messenger RNA decapping: DCP1A DCP1B DCP2 DCPS EDC3 EDC4

see also: disorders of transcription and post transcriptional modification, Transcription B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

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DCP2

Interactions [edit]

References [edit]

Further reading [edit]

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