digplanet beta 1: Athena
Share digplanet:


Applied sciences






















Cetrimonium bromide
Cetyltrimethyl ammonium bromide.svg
IUPAC name
hexadecyl-trimethyl-ammonium bromide
57-09-0 YesY
ATC code D08AJ02
ChemSpider 5754 YesY
Jmol-3D images Image
KEGG D03454 YesY
PubChem 5974
Molar mass 364.45 g/mol
Appearance white powder
Melting point 237 to 243 °C (459 to 469 °F; 510 to 516 K) (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 N verify (what isYesY/N?)
Infobox references

Cetrimonium bromide ((C16H33)N(CH3)3Br, cetyltrimethylammonium bromide, hexadecyltrimethylammonium bromide, CTAB) is an amine based cationic quaternary surfactant.

It is one of the components of the topical antiseptic cetrimide.[1] The cetrimonium (or hexadecyltrimethylammonium) cation is an effective antiseptic agent against bacteria and fungi. Its uses also include providing a buffer solution for the extraction of DNA. It has been widely used in synthesis of gold nanoparticles (e.g., spheres, rods, bipyramids) and mesoporous silica nanoparticles (e.g., MCM-41). It is also widely used in hair conditioning products.

As any surfactant, it forms micelles in aqueous solutions. At 303 K (30 °C) it forms micelles with aggregation number 75-120 (depending on method of determination, usually average ~95) and degree of ionization α (fractional charge) 0.2–0.1 (from low to high concentration).

The standard constant of Br- counterion binding to the micelle at 303 K (30 °C) is K° ≈ 400. This value is calculated from Br- and CTA+ ion selective electrode measurements and conductometry data by using literature data for micelle size (r = ~3 nm), extrapolated to the critical micelle concentration of 1 mM. However, it varies with total surfactant concentration so it is extrapolated to the point at which the concentration of micelles is zero)

The closely related compounds cetrimonium chloride and cetrimonium stearate are also used as topic antiseptics, and may be found in many household products such as shampoos and cosmetics, while cetrimonium bromide, due to its high cost, is only found in select cosmetics.

Use of CTAB in protein electrophoresis[edit]

Because of the broad distribution of negative charges in glycoproteins, these form broad, fuzzy bands in SDS-PAGE (Laemmli-electrophoresis).[2] This can be avoided by using positively charged detergents like CTAB [3][4] instead of the negatively charged SDS. Proteins can be blotted from CTAB-gels in analogy to western blots ("eastern blot"), and CTAB-PAGE can be used as second dimension after IEF. Myelin-associated high hydrophobic protein can be analyzed using CTAB 2-DE.

See also[edit]


  1. ^ Ito., Emma (November 2009). "Editorial". Potential Use of Cetrimonium Bromide as an Apoptosis-Promoting Anticancer Agent for Head and Neck Cancer 76 (5): 969–983. Retrieved November 2009. 
  2. ^ Laemmli, UK (1970). "Cleavage of structural proteins during the assembly of the head of bacteriophage T4". Nature 227 (5259): 680–5. doi:10.1038/227680a0. PMID 5432063. 
  3. ^ Buxbaum, Engelbert (2003). "Cationic electrophoresis and electrotransfer of membrane glycoproteins". Analytical Biochemistry 314 (1): 70–6. doi:10.1016/S0003-2697(02)00639-5. PMID 12633604. 
  4. ^ E. Buxbaum: Cationic electrophoresis and eastern blotting. In: B.T. Kurien & R.H. Scofield (ed): Protein blotting and detection – Methods and protocols, (Meth. Mol. Biol. 536), Dordrecht (Humana) 2009, ISBN 978-1-934115-73-2, pp. 115–28

Further reading[edit]

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Cetrimonium_bromide — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.

33 news items

Huffington Post

Huffington Post
Fri, 24 Jul 2015 08:22:38 -0700

These days, it seems like there's a new beauty trend every week. With the millions of products on the market, it's hard to keep track of the best brands in the U.S., let alone abroad. But thanks to the site Travel Beauty, finding the best beauty brands ...
Korea JoongAng Daily
Thu, 04 Sep 2014 08:35:33 -0700

The Environmental Working Group, an health research and advocacy organization, said cetrimonium bromide is a skin toxicant and allergen. However, it also said the substance is “safe for use in cosmetics, subject to concentration or use limitations.”
Korea Times
Sun, 21 Sep 2014 02:45:00 -0700

Baby wipes are igniting health concerns among consumers due to reports they contain high levels of toxic substances. But the authorities have not made it clear as to whether the reported level of the chemical compound, cetrimonium bromide, is harmful ...


Tue, 02 Sep 2014 00:30:00 -0700

수개월 전 MBC '불만제로UP'에서 시판 중인 영유아 물티슈 23개 제품 중 6개에서 가습기 살균제의 한 성분인 클로로메틸이소치아졸리논(CMIT)과 메칠이소치아졸리논(MIT)이 검출됐다. CMIT와 MIT는 폐 손상을 유발하는 물질로, 이로 인해 많은 피해가 발생하였던 ...
Truth In Aging
Mon, 09 Jan 2012 15:40:31 -0800

WEN Fig Cleansing Conditioner ($32): The WEN hair care products can often be seen hawked on infomercials as well as network shopping channels. The testimonials are somewhat over the top in glowing commentary and the women shaking their heads ...
Truth In Aging
Sat, 14 May 2011 14:38:42 -0700

Andre Walker's Hair Keratin Conditioner starts out promisingly with a base of aloe leaf water, but quickly moves on to the surfactant cetrimonium bromide. According to the EWG, one or more animal studies show brain and nervous system effects at low ...
Truth In Aging (blog)
Tue, 05 Jan 2010 09:41:41 -0800

Take, for instance, the surfactant cetrimonium bromide. According to the EWG, one or more animal studies show brain and nervous system effects at low doses, there is strong evidence that it is a human skin toxicant, and animal studies show reproductive ...


Thu, 11 Sep 2014 02:56:15 -0700

환경정의, 환경운동연합 등이 참여하고 있는 발암물질없는사회만들기국민행동(http://nocancer.kr, 이하 발암물질국민행동)은 유해성 논란이 휩싸인 물티슈 성분인 '세트리모늄브로마이드'(Cetrimonium Bromide)에 대한 부모들의 이해를 돕기 위해 11일 공식 논평을 ...

Oops, we seem to be having trouble contacting Twitter

Support Wikipedia

A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia. Please add your support for Wikipedia!

Searchlight Group

Digplanet also receives support from Searchlight Group. Visit Searchlight