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Cetrimonium bromide
Cetyltrimethyl ammonium bromide.svg
Identifiers
CAS number 57-09-0 YesY
PubChem 5974
ChemSpider 5754 YesY
UNII L64N7M9BWR YesY
KEGG D03454 YesY
ChEBI CHEBI:3567 YesY
ChEMBL CHEMBL113150 N
ATC code D08AJ02, R02AA17
Jmol-3D images Image 1
Properties
Molecular formula C19H42BrN
Molar mass 364.45 g/mol
Appearance white powder
Melting point 237–243 °C (decomposes)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Cetrimonium bromide ((C16H33)N(CH3)3Br, cetyltrimethylammonium bromide, hexadecyltrimethylammonium bromide, CTAB) is one of the components of the topical antiseptic cetrimide.[1] The cetrimonium (or hexadecyltrimethylammonium) cation is an effective antiseptic agent against bacteria and fungi.

It is a cationic surfactant. Its uses include providing a buffer solution for the extraction of DNA. It has been widely used in synthesis of gold nanoparticles (e.g., spheres, rods, bipyramids) and mesoporous silica nanoparticles (e.g., MCM-41). It is also widely used in hair conditioning products.

As any surfactant, it forms micelles in aqueous solutions. At 303 K (30 °C) it forms micelles with aggregation number 75-120 (depending on method of determination, usually average ~95) and degree of ionization α (fractional charge) 0.2–0.1 (from low to high concentration).

The standard constant of Br- counterion binding to the micelle at 303 K (30 °C) is K° ≈ 400. This value is calculated from Br- and CTA+ ion selective electrode measurements and conductometry data by using literature data for micelle size (r = ~3 nm), extrapolated to the critical micelle concentration of 1 mM. However, it varies with total surfactant concentration so it is extrapolated to the point at which the concentration of micelles is zero)

The closely related compounds cetrimonium chloride and cetrimonium stearate are also used as topic antiseptics, and may be found in many household products such as shampoos and cosmetics, while cetrimonium bromide, due to its high cost, is only found in select cosmetics.

Use of CTAB in protein electrophoresis[edit]

Because of the broad distribution of negative charges in glycoproteins, these form broad, fuzzy bands in SDS-PAGE (Laemmli-electrophoresis).[2] This can be avoided by using positively charged detergents like CTAB [3][4] instead of the negatively charged SDS. Proteins can be blotted from CTAB-gels in analogy to western blots ("eastern blot"), and CTAB-PAGE can be used as second dimension after IEF. Myelin-associated high hydrophobic protein can be analyzed using CTAB 2-DE.

See also[edit]

References[edit]

  1. ^ Ito., Emma (November 2009). "Editorial". Potential Use of Cetrimonium Bromide as an Apoptosis-Promoting Anticancer Agent for Head and Neck Cancer 76 (5): 969–983. Retrieved November 2009. 
  2. ^ Laemmli, UK (1970). "Cleavage of structural proteins during the assembly of the head of bacteriophage T4". Nature 227 (5259): 680–5. doi:10.1038/227680a0. PMID 5432063. 
  3. ^ Buxbaum, Engelbert (2003). "Cationic electrophoresis and electrotransfer of membrane glycoproteins". Analytical Biochemistry 314 (1): 70–6. doi:10.1016/S0003-2697(02)00639-5. PMID 12633604. 
  4. ^ E. Buxbaum: Cationic electrophoresis and eastern blotting. In: B.T. Kurien & R.H. Scofield (ed): Protein blotting and detection – Methods and protocols, (Meth. Mol. Biol. 536), Dordrecht (Humana) 2009, ISBN 978-1-934115-73-2, pp. 115–28

Further reading[edit]


Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Cetrimonium_bromide — Please support Wikipedia.
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71 news items

 
Korea JoongAng Daily
Thu, 04 Sep 2014 14:41:35 -0700

The Environmental Working Group, an health research and advocacy organization, said cetrimonium bromide is a skin toxicant and allergen. However, it also said the substance is “safe for use in cosmetics, subject to concentration or use limitations.”
 
Korea Times
Sun, 21 Sep 2014 02:45:00 -0700

Baby wipes are igniting health concerns among consumers due to reports they contain high levels of toxic substances. But the authorities have not made it clear as to whether the reported level of the chemical compound, cetrimonium bromide, is harmful ...

뉴스토피아

뉴스토피아
Tue, 02 Sep 2014 00:30:00 -0700

수개월 전 MBC '불만제로UP'에서 시판 중인 영유아 물티슈 23개 제품 중 6개에서 가습기 살균제의 한 성분인 클로로메틸이소치아졸리논(CMIT)과 메칠이소치아졸리논(MIT)이 검출됐다. CMIT와 MIT는 폐 손상을 유발하는 물질로, 이로 인해 많은 피해가 발생하였던 ...

국제신문

국제신문
Wed, 29 Oct 2014 05:09:20 -0700

CMIT와 MIT가 들어 있지 않은 물티슈를 골라놓고 이제 괜찮으려니 한숨 돌리니까 이번엔 '세트리모늄브로마이드(Cetrimonium Bromide)'라는 것이 문제란다. 양이온성의 계면 활성제인 세트리모늄브로마이드(브로민화 세트리모늄)는 세균이나 진균류에 효과적인 ...
 
코스인코리아닷컴
Sun, 26 Oct 2014 18:07:30 -0700

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Pharmaceutical Business Review
Thu, 21 Aug 2014 04:15:00 -0700

... biopharmaceutical and pharmaceutical industries, such as insulin human for cell culture media and cGMP manufactured quaternary ammonium compounds (usually referred to as quats) such as benzalkonium chloride, cetrimide and cetrimonium bromide.
 
Pharmaceutical Business Review
Thu, 05 Jun 2014 08:45:40 -0700

... biopharmaceutical and pharmaceutical industries, such as insulin human for cell culture media and cGMP manufactured quaternary ammonium compounds (usually referred to as quats) such as benzalkonium chloride, cetrimide and cetrimonium bromide.

The Korea Bizwire

The Korea Bizwire
Fri, 03 Oct 2014 02:24:37 -0700

Recently a news report caused stir among consumers as it exposed most wet wipe products sold in Korea contain “cetrimonium bromide,” an antiseptic agent, that may cause series damage to the skin and eye. To address these consumer concerns, ...
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