| BTB and CNC homology 1, basic leucine zipper transcription factor 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | BACH2; BTBD25 | ||||||||||||
| External IDs | OMIM: 605394 HomoloGene: 7240 GeneCards: BACH2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 60468 | 12014 | |||||||||||
| Ensembl | ENSG00000112182 | ENSMUSG00000040270 | |||||||||||
| UniProt | Q9BYV9 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001170794 | NM_001109661 | |||||||||||
| RefSeq (protein) | NP_001164265 | NP_001103131 | |||||||||||
| Location (UCSC) | Chr 6: 90.64 – 91.01 Mb |
Chr 4: 32.24 – 32.59 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Transcription regulator protein BACH2 is a protein that in humans is encoded by the BACH2 gene.[1][2][3]
References [edit]
- ^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (Sep 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene 19 (33): 3739–49. doi:10.1038/sj.onc.1203716. PMID 10949928.
- ^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (Oct 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood 102 (9): 3317–22. doi:10.1182/blood-2002-12-3656. PMID 12829606.
- ^ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2".
Further reading [edit]
- Oyake T, Itoh K, Motohashi H, et al. (1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.". Mol. Cell. Biol. 16 (11): 6083–95. PMC 231611. PMID 8887638.
- Kobayashi A, Yamagiwa H, Hoshino H, et al. (2000). "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain.". Mol. Cell. Biol. 20 (5): 1733–46. doi:10.1128/MCB.20.5.1733-1746.2000. PMC 85356. PMID 10669750.
- Hoshino H, Kobayashi A, Yoshida M, et al. (2000). "Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element.". J. Biol. Chem. 275 (20): 15370–6. doi:10.1074/jbc.275.20.15370. PMID 10809773.
- Vieira SA, Deininger MW, Sorour A, et al. (2002). "Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene.". Genes Chromosomes Cancer 32 (4): 353–63. doi:10.1002/gcc.1200. PMID 11746976.
- Muto A, Tashiro S, Tsuchiya H, et al. (2002). "Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies.". J. Biol. Chem. 277 (23): 20724–33. doi:10.1074/jbc.M112003200. PMID 11923289.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Takakuwa T, Luo WJ, Ham MF, et al. (2004). "Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression.". Am. J. Pathol. 164 (3): 967–74. doi:10.1016/S0002-9440(10)63184-7. PMC 1614712. PMID 14982850.
- Tashiro S, Muto A, Tanimoto K, et al. (2004). "Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2.". Mol. Cell. Biol. 24 (8): 3473–84. doi:10.1128/MCB.24.8.3473-3484.2004. PMC 381671. PMID 15060166.
- Motamed-Khorasani A, Jurisica I, Letarte M, et al. (2007). "Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression.". Oncogene 26 (2): 198–214. doi:10.1038/sj.onc.1209773. PMID 16832351.
- Yoshida C, Yoshida F, Sears DE, et al. (2007). "Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1.". Blood 109 (3): 1211–9. doi:10.1182/blood-2005-12-040972. PMID 17018862.
- Ono A, Kono K, Ikebe D, et al. (2007). "Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells.". Genes Chromosomes Cancer 46 (1): 67–74. doi:10.1002/gcc.20390. PMID 17044046.
- Ikeda T, Shibata J, Yoshimura K, et al. (2007). "Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy.". J. Infect. Dis. 195 (5): 716–25. doi:10.1086/510915. PMID 17262715.
- Hoshino H, Nishino TG, Tashiro S, et al. (2007). "Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression.". J. Biochem. 141 (5): 719–27. doi:10.1093/jb/mvm073. PMID 17383980.
External links [edit]
- BACH2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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