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The proper development of the Atrioventricular canal into its prospective components (The heart septum and associated valves) to create a clear division between the four compartments of the heart and ensure proper blood movement through the heart, are essential for proper heart function. When this process does not happen correctly, a child will develop atrioventricular canal defect which occurs in 2 out of every 10,000 births. It also has a correlation with Down Syndrome because 20% of children with Down Syndrome suffer from atrioventricular canal disease as well. This is a very serious condition and surgery is necessary within the first six months of life for a child. [1] Half of the children who are untreated with this condition die during their first year due to heart failure of pneumonia.[2]

Atrioventricular canal defect is a combination of abnormalities of the heart and is present at birth. There is a problem when there are holes present in the walls that separate chambers (septum), as well as when valves are incorrectly constructed. There are other names for these heart abnormalities such as endocardial cushion defects or atrioventricular septal defect[3]

Development[edit]

This a photo of the basic anatomical structures of the heart. Take note of how during "normal" heart development all four chambers are separated and the mitral and tricupsid valves are properly developed.

In a normal healthy heart there are 4 chambers. This consists of right and left atria, and right and left ventricles. The Right atria and right ventricle's function is to pump blood to the lungs while the left atria and left ventricles pump blood to the rest of the body. There are valves in place that inhibit back-flow between these chambers.[3]

Clinical relevance[edit]

Atrioventricular canal defect[edit]

This is an echocardiography of "Complete" Atriventricular Canal Disorder. There is a clear absence of lower septum that would separate all four chambers of the heart

This defect is developed because of the improper formation of the endocardial cushions, and their job is to separate the different parts of the heart during development when they fuse. It is strongly associated with Down's syndrome. The structures that develop from the fusion of the endocardial cushions are:

Atrioventricular canal defect may be divided into partial or complete forms. In the partial form, openings between the left and right atria and improper formation of the mitral valve exist. In the complete form, there is free movement in all chambers because there is a large hole where the atria and ventricles meet, and instead of there being two valves there is one common valve. [3]

Surgery is usually conducted in-between the 3rd and 6th month of life, and with this condition the earlier the better. Usually, intracardiac repair is completed which is when they close the holes in the septum and they make two new atrioventricular valves that is available from the underdeveloped common valve leaflet.[2]

See also[edit]

References[edit]

  1. ^ Brown, David MD "Atrioventricular Canal Defect" Children's Hospital Boston 20120 http://www.childrenshospital.org/az/Site521/mainpageS521P0.html
  2. ^ a b Calabro, Raffaele & Limongelli, Giuseppe "Complete Atrioventricular Canal" 2006 April 5, US National Library of Medicine National Institutes of Health http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459121/
  3. ^ a b c Mayo Clinic September 12, 2012"Atrioventricular Canal Defect" http://www.mayoclinic.com/health/atrioventricular-canal-defect/DS00745
  4. ^ Cincinnati Children's Hospital "Atrioventricular Septal Defect" April 2010 http://www.cincinnatichildrens.org/health/a/avsd/

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Atrioventricular_canal — Please support Wikipedia.
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2 news items

Medscape

Medscape
Wed, 02 Apr 2014 16:03:45 -0700

... the same 3-vessel view was also very high, at 88%. In contrast, as expected, the 3-vessel view performed poorly in the detection of isolated 4-chamber view anomalies, such as atrioventricular canal defects. Table. Performance of 3-Vessel View ...
 
The Times-Picayune
Wed, 26 Mar 2014 11:03:27 -0700

Lucas Ruiz was born with Down syndrome and atrioventricular canal defect, a condition that left him with holes in his heart, requiring corrective surgery and a feeding tube. In explaining why she poisoned her child by injecting the hand sanitizer into ...
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