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The proper development of the atrioventricular canal into its prospective components (The heart septum and associated valves) to create a clear division between the four compartments of the heart and ensure proper blood movement through the heart, are essential for proper heart function. When this process does not happen correctly, a child will develop atrioventricular canal defect which occurs in 2 out of every 10,000 births.[1] It also has a correlation with Down Syndrome because 20% of children with Down Syndrome suffer from atrioventricular canal disease as well. This is a very serious condition and surgery is necessary within the first six months of life for a child.[2] Half of the children who are untreated with this condition die during their first year due to heart failure or pneumonia.[3]

Atrioventricular canal defect is a combination of abnormalities of the heart and is present at birth. There is a problem when there are holes present in the walls that separate chambers (septa),as well as when valves are incorrectly constructed. There are other names for these heart abnormalities such as endocardial cushion defects or atrioventricular septal defect[4]

Development[edit]

A photo of the basic anatomical structures of the heart. During normal heart development all four chambers are separated and the mitral and tricupsid valves are properly developed.

In a normal healthy heart there are four chambers. This consists of right and left atria, and right and left ventricles. The right atrium and right ventricle function to pump blood to the lungs while the left atrium and left ventricle pump blood to the rest of the body. There are valves in place that inhibit back-flow between these chambers.[4]

Clinical relevance[edit]

Atrioventricular canal defect[edit]

This is an echocardiography of "Complete" Atriventricular Canal Disorder. There is a clear absence of lower septum that would separate all four chambers of the heart

This defect is developed because of the improper formation of the endocardial cushions, and their job is to separate the different parts of the heart during development when they fuse. It is strongly associated with Down's syndrome. The structures that develop from the fusion of the endocardial cushions are:

Atrioventricular canal defect may be divided into partial or complete forms. In the partial form, openings between the left and right atria and improper formation of the mitral valve exist. In the complete form, there is free movement in all chambers because there is a large hole where the atria and ventricles meet, and instead of there being two valves there is one common valve.[4]

Surgery is usually conducted in-between the 3rd and 6th month of life, and with this condition the earlier the better. Usually, intracardiac repair involves closing the holes in the septum and the creation of two new atrioventricular valves from the underdeveloped common valve leaflet.[3]

See also[edit]

References[edit]

  1. ^ "Orphanet: Complete atrioventricular canal". www.orpha.net. Retrieved 2015-10-09. 
  2. ^ Brown, David MD "Atrioventricular Canal Defect" Children's Hospital Boston 20120 http://www.childrenshospital.org/az/Site521/mainpageS521P0.html
  3. ^ a b Calabro, Raffaele & Limongelli, Giuseppe "Complete Atrioventricular Canal" 2006 April 5, US National Library of Medicine National Institutes of Health http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459121/
  4. ^ a b c Mayo Clinic September 12, 2012"Atrioventricular Canal Defect" http://www.mayoclinic.com/health/atrioventricular-canal-defect/DS00745
  5. ^ Cincinnati Children's Hospital "Atrioventricular Septal Defect" April 2010 http://www.cincinnatichildrens.org/health/a/avsd/

Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Atrioventricular_canal — Please support Wikipedia.
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114 news items

East Idaho News

East Idaho News
Mon, 01 Feb 2016 10:56:15 -0800

In June, before Beckett was even born, Beckett's mother, Rachael Gray, found out Beckett had a defect of the atrioventricular canal. This meant he would have to have surgery. Rachael said most doctors won't perform open heart surgery on an infant that ...
 
Union Democrat
Thu, 04 Feb 2016 00:26:15 -0800

Common types of heart defects include aortic valve stenosis (AVS), atrial septal defect (ASD), coarctation of the aorta (CoA), complete atrioventricular canal defect (CAVC), d-transposition of the great arteries, Ebstein's anomaly, hypoplastic left ...

Idaho Press-Tribune

Idaho Press-Tribune
Wed, 27 Jan 2016 17:30:42 -0800

29 with several heart defects, Monday afternoon at their Middleton home. Also pictured is his wife Rachael and their daughter Madelyn, 17 months. Beckett is doing well following his heart surgery to repair a defect of his atrioventricular canal in ...

People Magazine

People Magazine
Wed, 16 Sep 2015 13:00:31 -0700

A Louisiana mother pleaded guilty to killing her 17-month-old son by injecting hand sanitizer into his feeding tube, the Plaquemines Parish District Attorney's Office tells PEOPLE. Lucas Ruiz was born with Down syndrome and an atrioventricular canal ...

6 On Your Side

6 On Your Side
Sun, 25 Oct 2015 20:52:37 -0700

Beckett was diagnosed with atrioventricular canal defect, which requires surgery most doctors won't perform until four to six months of age. Doctors predicted Beckett wouldn't show any symptoms of his condition until he was at least two months old, but ...

KTVB

KTVB
Thu, 22 Oct 2015 21:18:45 -0700

Twenty weeks into pregnancy, the Grays learned their baby had a heart defect, called an atrioventricular canal defect. Late September, Beckett was born, and deemed healthy enough to go home. Three days in, something scary started to happen. "He was in ...
 
Washington Post
Mon, 05 Oct 2015 21:07:30 -0700

Abigail has an atrioventricular canal defect, where there is a hole in the top chamber of the atrium and another hole in the chamber of the ventricle. Basically the middle of the heart is missing. It is a common defect of children with Down Syndrome ...

LifeNews.com

LifeNews.com
Mon, 21 Sep 2015 06:07:30 -0700

In Louisiana, Erika Wigstrom has pleaded guilty to killing her 17-month-old baby by putting hand sanitizer into his feeding tube. Her son, Lucas Ruiz, was born with Down syndrome and an atrioventricular canal defect, which required that he take in ...
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