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Aromatic amino acids (AAA)[1] are amino acids that include an aromatic ring.

Examples include:

PhenylalaninetyrosineL-DOPA → (dopamine) → (epinephrine) → (norepinephrine)

Tryptophan5-hydroxytryptophan → (serotonin)

Histidine → (histamine)

Phenylalaninetyrosinethyroxine

See also[edit]

Phenylalanine, histidine, and tryptophan are essential amino acids for animals. Since they are not synthesized in the human body, they must be derived from the diet. Tyrosine is semi-essential; it can be synthesized, but only from phenylalanine. A lack of the enzyme phenylalanine hydroxylase, used in tyrosine synthesis, causes phenylketonuria, and concurrently renders tyrosine an essential amino acid.

All plants and micro-organisms must synthesize their aromatic amino acids through the shikimate pathway in order to make proteins, unlike animals, which obtain them through their diet. Because of the energy intensive nature of amino acid biosynthesis, animals have lost these costly metabolic pathways, since they can obtain aromatic amino acids by ingesting other organisms. Herbicides and antibiotics take advantage of this by inhibiting enzymes involved in aromatic acid synthesis, thereby rendering them toxic to plants and micro-organisms but not animals.

External links[edit]

References[edit]

  1. ^ Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 0-397-54589-4. 

Further reading[edit]



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2 news items

Farm Futures

Farm Futures
Tue, 15 Jul 2014 04:37:30 -0700

Glyphosate, for example, disables the synthesis of aromatic amino acids in a plant by binding to the enzyme EPSP synthase.(4). There are believed to be thousands of sites of action in plants capable of being targeted by herbicides. Creating herbicides ...

Lankaweb

Lankaweb
Sun, 06 Jul 2014 06:29:17 -0700

Consequently, weeds die of protein starvation,” because of their inability to synthesize essential aromatic amino acids and thus plant proteins. This particular enzyme pathway and mechanism of action is not present in animals or humans (i.e., this ...
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