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Aromatic amino acids (AAA)[1] are amino acids that include an aromatic ring.

Examples include:

PhenylalaninetyrosineL-DOPA → (dopamine) → (epinephrine) → (norepinephrine)

Tryptophan5-hydroxytryptophan → (serotonin)

Histidine → (histamine)

Phenylalaninetyrosinethyroxine

See also[edit]

Phenylalanine, histidine, and tryptophan are essential amino acids for animals. Since they are not synthesized in the human body, they must be derived from the diet. Tyrosine is semi-essential; it can be synthesized, but only from phenylalanine. A lack of the enzyme phenylalanine hydroxylase, used in tyrosine synthesis, causes phenylketonuria, and concurrently renders tyrosine an essential amino acid.

All plants and micro-organisms must synthesize their aromatic amino acids through the shikimate pathway in order to make proteins, unlike animals, which obtain them through their diet. Because of the energy intensive nature of amino acid biosynthesis, animals have lost these costly metabolic pathways, since they can obtain aromatic amino acids by ingesting other organisms. Herbicides and antibiotics take advantage of this by inhibiting enzymes involved in aromatic acid synthesis, thereby rendering them toxic to plants and micro-organisms but not animals.

External links[edit]

References[edit]

  1. ^ Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 0-397-54589-4. 

Further reading[edit]



Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Aromatic_amino_acids — Please support Wikipedia.
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86 news items

 
Nature.com
Thu, 20 Nov 2014 05:43:24 -0800

1a)11. Using the structural information and adenylation domain selectivity-conferring code, the researchers aimed to expand the active site to enable the efficient incorporation of aromatic amino acids containing alkyne or azide functional groups ...
 
HealthCanal.com
Fri, 21 Nov 2014 00:14:58 -0800

MEDFORD/SOMERVILLE, Mass-- Tufts University School of Engineering researchers and collaborators from Texas A&M University have published the first research to use computational modeling to predict and identify the metabolic products of ...
 
Common Ground.ca
Fri, 31 Oct 2014 18:32:35 -0700

Glyphosate binds tightly to the manganese atom at the centre of the EPSPS metalloprotein, so tightly that the protein cannot move and do its work making aromatic amino acids. No protein synthesis means there is no metabolic work possible, a quick death ...
 
EurekAlert (press release)
Mon, 11 Mar 2013 21:03:01 -0700

"It's the aromatic amino acids that make it a wire," says lead author Derek Lovley of the University of Massachusetts, Amherst. Lovley and his colleagues removed the pivotal amino acids from the pili and replaced them with smaller, non-aromatic amino ...
 
BioTechniques.com
Mon, 09 Aug 2010 12:23:41 -0700

We describe the use of an auto-induction medium containing N-(phosphono-methyl)glycine (glyphosate) as a means for high-level introduction of nonstandard aromatic amino acids into a protein. We illustrate this approach by preparing maltose binding ...
 
physicsworld.com
Wed, 27 Mar 2013 10:22:29 -0700

A team of researchers in the US claims to have found clear evidence of a microbe that conducts electricity along protein filaments, just like a metal. By showing that aromatic amino acids are critical to both the electrical and respiratory activities ...
 
News-Medical.net
Fri, 01 Aug 2014 00:22:06 -0700

Aromatic amino acids, present in most proteins, fluoresce upon UV excitation. The fluorescence spectrum of a protein gives a clear idea of the conformational state of the protein and its amino acid composition. During the transition of the protein from ...
 
spectroscopyNOW.com
Sun, 06 Jan 2013 18:03:45 -0800

... such as aromatic, hydrophobic, acidic, or basic amino acids can act as antioxidants. Tryptophan, tyrosine, arginine, lysine, cysteine, and histidine, for instance have antioxidant properties. Aromatic amino acids are proton donors to electron ...
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