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Aromatic amino acids (AAA)[1] are amino acids that include an aromatic ring.

Examples include:

PhenylalaninetyrosineL-DOPA → (dopamine) → (epinephrine) → (norepinephrine)

Tryptophan5-hydroxytryptophan → (serotonin)

Histidine → (histamine)

Phenylalaninetyrosinethyroxine

See also[edit]

Phenylalanine, histidine, and tryptophan are essential amino acids for animals. Since they are not synthesized in the human body, they must be derived from the diet. Tyrosine is semi-essential; it can be synthesized, but only from phenylalanine. A lack of the enzyme phenylalanine hydroxylase, used in tyrosine synthesis, causes phenylketonuria, and concurrently renders tyrosine an essential amino acid.

All plants and micro-organisms must synthesize their aromatic amino acids through the shikimate pathway in order to make proteins, unlike animals, which obtain them through their diet. Because of the energy intensive nature of amino acid biosynthesis, animals have lost these costly metabolic pathways, since they can obtain aromatic amino acids by ingesting other organisms. Herbicides and antibiotics take advantage of this by inhibiting enzymes involved in aromatic acid synthesis, thereby rendering them toxic to plants and micro-organisms but not animals.

External links[edit]

References[edit]

  1. ^ Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 0-397-54589-4. 

Further reading[edit]



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2 news items

 
Pitchcare (press release)
Wed, 27 Aug 2014 22:15:00 -0700

These amino acids are only synthesised in plants and microorganisms. Animals obtain aromatic amino acids by ingesting plants and other organisms, therefore this pathway is a very appropriate target when seeking to focus on controlling species within ...
 
Food Consumer
Wed, 27 Aug 2014 14:11:15 -0700

Five branched chain and aromatic amino acids (isoleucine, leucine, valine, tyrosine, and phenylalanine) showed significant associations with future diabetes, and results were replicated in an independent, prospective cohort. [116]. Authors proposed ...
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