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Aromatic amino acids (AAA)[1] are amino acids that include an aromatic ring.

Examples include:

PhenylalaninetyrosineL-DOPA → (dopamine) → (epinephrine) → (norepinephrine)

Tryptophan5-hydroxytryptophan → (serotonin)

Histidine → (histamine)

Phenylalaninetyrosinethyroxine

Phenylalanine, histidine, and tryptophan are essential amino acids for animals. Since they are not synthesized in the human body, they must be derived from the diet. Tyrosine is semi-essential; it can be synthesized, but only from phenylalanine. A lack of the enzyme phenylalanine hydroxylase, used in tyrosine synthesis, causes phenylketonuria, and concurrently renders tyrosine an essential amino acid.

Animals get aromatic amino acids from diet, but all plants and micro-organisms must synthesize their aromatic amino acids through the metabolically costly shikimate pathway in order to make proteins. Herbicides and antibiotics work by inhibiting enzymes involved in aromatic acid synthesis, thereby rendering them toxic to plants and micro-organisms but not to animals.


All plants and micro-organisms must synthesize their aromatic amino acids through the shikimate pathway in order to make proteins, unlike animals, which obtain them through their diet. Because of the energy intensive nature of amino acid biosynthesis, animals have lost these costly metabolic pathways, since they can obtain aromatic amino acids by ingesting other organisms. Herbicides and antibiotics take advantage of this by inhibiting enzymes involved in aromatic acid synthesis, thereby rendering them toxic to plants and micro-organisms but not animals.

See also[edit]

External links[edit]

References[edit]

  1. ^ Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 0-397-54589-4. 

Further reading[edit]



Original courtesy of Wikipedia: http://en.wikipedia.org/wiki/Aromatic_amino_acids — Please support Wikipedia.
This page uses Creative Commons Licensed content from Wikipedia. A portion of the proceeds from advertising on Digplanet goes to supporting Wikipedia.

86 news items

 
BMC Blogs Network
Sat, 13 Jun 2015 03:21:50 -0700

Furthermore, the simplicity of vanillin structure has led to the use of various precursors in the microbial or enzymatic process of vanillin production: lignin, curcumin, siam benzoin resin, phenolic stilbenes, isoeugenol, eugenol, ferulic acid ...
 
The Asian Age
Tue, 16 Jun 2015 17:35:53 -0700

It is claimed that Round-up and Round-up ready crops are safe for humans because humans do not have the shikimate pathway — a seven step metabolic route used by bacteria, fungi, algae, parasites and plants for the biosynthesis of aromatic amino acids.
 
AllAfrica.com
Thu, 04 Jun 2015 05:11:15 -0700

It is a non-selective systemic herbicide that is applied to plant parts above the soil. Verdoorn explains that the plant takes it up in its system and it prevents the synthesis of certain aromatic amino acids that are essential for biosynthesis of ...
 
physicsworld.com
Wed, 27 Mar 2013 10:22:29 -0700

A team of researchers in the US claims to have found clear evidence of a microbe that conducts electricity along protein filaments, just like a metal. By showing that aromatic amino acids are critical to both the electrical and respiratory activities ...
 
Phys.Org
Tue, 12 Mar 2013 02:09:21 -0700

"It's the aromatic amino acids that make it a wire," says lead author Derek Lovley of the University of Massachusetts, Amherst. Lovley and his colleagues removed the pivotal amino acids from the pili and replaced them with smaller, non-aromatic amino ...

Phys.Org

Phys.Org
Wed, 04 Mar 2015 08:30:00 -0800

In a series of papers going back to 2011, Lovley's group provided several lines of experimental evidence that Geobacter pili conduct electrons through the close interaction of aromatic amino acids in the protein filament structure. As Malvankar ...
 
BioTechniques.com
Mon, 09 Aug 2010 12:23:41 -0700

We describe the use of an auto-induction medium containing N-(phosphono-methyl)glycine (glyphosate) as a means for high-level introduction of nonstandard aromatic amino acids into a protein. We illustrate this approach by preparing maltose binding ...
 
Medscape
Thu, 12 Feb 2015 16:22:30 -0800

Serum levels of an amino acid are strongly associated with the risk for type 2 diabetes in South Asian men, potentially offering a target for novel treatments and prevention strategies, suggest the results of a new UK study. The research, which spanned ...
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